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Within many species, larger offspring have higher fitness. While the presence of an offspring size–fitness relationship is canonical in life-history theory, the mechanisms that determine why this relationship exists are unclear. Linking metabolic theory to life-history theory could provide a general explanation for why larger offspring often perform better than smaller offspring. In many species,
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INTRODUCTION: Administrative healthcare databases are useful to investigate the epidemiology, health outcomes, quality indicators and healthcare utilisation concerning peptic ulcers and gastrointestinal bleeding, but the databases need to be validated in order to be a reliable source for research. The aim of this protocol is to perform the first systematic review of studies reporting the validatio
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In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif
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Introduction: Friedreich's ataxia (FRDA) is a hereditary disorder with progressive postural ataxia, dysarthria, neuropathy, muscle weakness and cardiomyopathy. Lack or malfunction of the protein frataxin due to mutations in the frataxin gene (FXN) is the cause of the disease. Most patients are homozygous for GAA trinucleotide expansions in FXN but disease can also be caused by heterozygosity for t