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Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation?
Simultaneous detection of L-glutamate and nitric oxide from adherently growing cells at known distance using disk shaped dual electrodes
Anti-arthritic effect of methotrexate: is it really mediated by adenosine?
The mechanism of action for the anti-arthritic effect of methotrexate (MTX) was investigated in rats with antigen-induced arthritis (AIA). Arthritis intensity was quantified as area under the curve (AUC) for the joint swelling. The response to MTX was in several respects similar to what is seen in the clinic. The drug reduced the AUC in a dose-dependent manner after oral weekly (2-4 mg/kg/week) or
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
Immunostaining for p16(INK4a) used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
The quality of cervical histopathology is critical to cervical cancer prevention, cancer treatment, and research programs. On the basis of the histology results further patient management is determined. However, the diagnostic interpretation of histologic hematoxylin-eosin (H&E)-stained slides is affected by substantial rates of discordance among pathologists. Overexpression of the cyclin-depe
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Co-localization of insect olfactory sensory cells improves the discrimination of closely separated odour sources
1. The sense of smell is crucial for fitness of most animals, enabling them to find mates, food and egg laying sites and to stay away from danger. Hence, odour molecules are detected by sensitive and specific olfactory sensory neurons (OSNs). In insects, the OSNs are stereotypically grouped into olfactory sensilla located mainly on the antennae. The functional significance of this co-localization
A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects
Association between DRD4 gene polymorphism and personality variation in great tits: a test across four wild populations
Polymorphisms in the dopamine receptor D4 gene (DRD4) have been related to individual variation in novelty-seeking or exploratory behaviour in a variety of animals, including humans. Recently, the human DRD4 orthologue was sequenced in a wild bird, the great tit (Parus major) and a single nucleotide polymorphism in exon 3 of this gene (SNP830) was shown to be associated with variation in explorato
Interannual Coupling between Summertime Surface Temperature and Precipitation over Land: Processes and Implications for Climate Change
The +1444C>T polymorphism in the CRP gene: a study on personality traits and suicidal behaviour.
TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer
Investigating the usefulness of satellite-derived fluorescence data in inferring gross primary productivity within the carbon cycle data assimilation system
Simulations of carbon fluxes with terrestrial biosphere models still exhibit significant uncertainties, in part due to the uncertainty in model parameter values. With the advent of satellite measurements of solar induced chlorophyll fluorescence (SIF), there exists a novel pathway for constraining simulated carbon fluxes and parameter values. We investigate the utility of SIF in constraining gross