Sökresultat

Objective: To evaluate if remission induced by low-dose prednisolone during the first 2 years of rheumatoid arthritis (RA) in the BARFOT glucocorticoid (GC) study had a sustained effect on radiological damage for a total of 4 years. Methods: A total of 150 of 211 eligible patients with RA who had been randomised to the 7.5 mg prednisolone group ( P) or no prednisolone group (NoP) in addition to th

Popular Abstract in Swedish Små, trådlösa och portabla apparater utgör idag en stor del av vår uppkopplade värld. Under det senaste decenniet har dock flera teknologiska framsteg lett mot en utveckling där allt från maskiner till kläder kommunicerar med varandra. Detta brukar kallas för "sakernas internet" och uppskattas involvera 50 miljarder enheter år 2020. Genom att förse dessa enheter med småThe modern small devices of today require cheap low power radio frequency (RF) transceivers that can provide reliable connectivity at all times. In an RF transceiver, the analog-to-digital converter (ADC) is one of the most important parts and it is also one of the main power consumers. There are several architectures for implementing an ADC, but in the last decade, continuous-time Delta-Sigma mod

Host resistance against parasites depends on three aspects: the ability to prevent, control and clear infections. In vertebrates the immune system consists of innate and adaptive immunity. Innate immunity is particularly important for preventing infection and eradicating established infections at an early stage while adaptive immunity is slow, but powerful, and essential for controlling infection

We present noble gas analyses of sediment-dispersed extraterrestrial chromite grains recovered from similar to 470 Myr old sediments from two quarries (Hallekis and Thorsberg) and of relict chromites in a coeval fossil meteorite from the Gullhogen quarry, all located ill Southern Sweden. Both the sediment-dispersed grains and the meteorite Gullhogen 001 were generated in the L-chondrite parent bod

A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo

Background: FAD dependent glucose dehydrogenase (GDH) currently raises enormous interest in the field of glucose biosensors. Due to its superior properties such as high turnover rate, substrate specificity and oxygen independence, GDH makes its way into glucose biosensing. The recently discovered GDH from the ascomycete Glomerella cingulata is a novel candidate for such an electrochemical applicat

OBJECTIVE: Data-driven methods for fMRI analysis are useful, for example, when an a priori model of signal variations is unavailable. However, activation sources are typically assumed to be linearly mixed, although non-linear properties of fMRI data, including resting-state data, have been observed. In this work, the non-linear locally linear embedding (LLE) algorithm is introduced for dimensional

A 3D model is developed to describe an anode-supported planar solid oxide fuel cell (SOFC), by ANSYS/Fluent evaluating reactions including methane steam reforming (MSR)/water-gas shift (WGSR) reactions in thick anode layer and H-2-O-2/CO-O-2 electrochemical reactions in anode active layer, coupled with heat, mass species, momentum, and ion/electron charges transport processes in SOFC. The predicte

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a

Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase