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Phosphoinositide (PIP) lipids are anionic phospholipids playing a fundamental role for the activity of several transmembrane and soluble proteins. Among all, phosphoinositol-3′,4′,5′-trisphosphate (PIP3) is a secondary signaling messenger that regulates the function of proteins involved in cell growth and gene transcription. The present study aims to reveal the structure of PIP-containing lipid me

Objective: We endeavored to create a comprehensive course in global surgery involving multinational exchange. Design: The course involved 2 weeks of didactics, 2 weeks of clinical rotations in a low-resource setting and 1 week for a capstone project. We evaluated our success through knowledge tests, surveys of the students, and surveys of our Zimbabwean hosts. Setting: The didactic portions were h

In October 2014, the European Council agreed on a target of improving overall energy efficiency by at least 27 per cent by 2030. According to the European Council's conclusions, this target should not be translated into nationally binding targets. Nevertheless individual Member States are free to set higher national objectives if desired. However, it is difficult to assess the degree of ambition o

Energy used in buildings is responsible for more than 40% of energy consumption and greenhouse gas (GHG) emissions of the EU and their share in cost-efficient GHG mitigation potentials is estimated to be even higher. In spite of its huge savings potential of up to 80%, achievements are very slow in the building sector and much stronger political action seems to be needed. One important step in thi

Popular Abstract in Swedish Pollenanalys, kronologi och paleomagnetism på tre senglaciala lokaler i södra Sverige Senglaciala sjösediment (d.v.s. avsatta under slutet av den senaste istiden) från tre bassänger i södra Sverige, Torreberga i Skåne, Farslycke i Blekinge och Bolmen i Småland, har studerats med avseende på pollensammansättning och paleomagnetism. Åldersbestämning och tidsjämförelser bThree sites, Torreberga in Skåne, Farslycke in Blekinge and Lake Bolmen in Småland, with Late Weichselian lake sediments were studied with respect to pollen analysis and palaeomagnetism. The chronologies are based on pollen stratigraphical correlations, radiocarbon dating and, for two of the sites, on a clay-varve chronology. The stratigraphies were correlated to the GRIP event stratigraphy and th

The aim of the present study was to model apparent serum half-lives of polybrominated diphenyl ethers (PBDEs) with 7-10 bromine substituents. Workers with occupational exposure to PBDEs have elevated serum levels of PBDEs, but these substances are also found in the general population and are ubiquitous environmental contaminants. The calculations were based on exposure assessments of rubber worker

The distribution of neuropeptide Y (NPY)-immunoreactivity was investigated in the rabbit maxillary sinus and adjacent ganglia. A moderate supply of NPY-containing nerve fibers occurred around seromucous glands and a denser supply around small blood vessels. Only a few immunoreactive nerve fibers were seen beneath the epithelium. Double immunostaining showed that vasoactive intestinal peptide (VIP)

Hormone-sensitive lipase (HSL) plays a key role in lipid metabolism and overall energy homoeostasis, by controlling the release of fatty acids from stored triglycerides in adipose tissue. Lipases and esterases form a protein superfamily with a common structural fold, called the alpha/beta-hydrolase fold, and a catalytic triad of serine, aspartic or glutamic acid and histidine. Previous alignments

Objective: The risk of certain psychiatric disorders is elevated among immigrants. To date, no population studies on immigrant health have addressed eating disorders. We examined whether risk of eating disorders in first- and second-generation immigrants differs from native-born Danes and Swedes. Method: All individuals born 1984–2002 (Danish cohort) and 1989–1999 (Swedish cohort) and residing in

The popularity of smartphones and the related growth of mobile application markets created a need for mobile platform owners to open their software platforms up to third party developers in order to meet user demand for mobile applications. This external innovation provides a tremendous opportunity for mobile platform owners to develop a volume and diversity of products they could not develop in-h

In this work, we investigate production of Drell-Yan (DY) pairs in proton-nucleus collisions in kinematic regions where the corresponding coherence length does not exceed the nuclear radius, RA, and the quantum coherence effects should be treated with special care. The results for the nucleus-to-nucleon production ratio available in the literature so far are usually based on the assumption of a ve

Subtelomeric 1q43q44 microdeletions cause a syndrome associating intellectual disability, microcephaly, seizures and anomalies of the corpus callosum. Despite several previous studies assessing genotype-phenotype correlations, the contribution of genes located in this region to the specific features of this syndrome remains uncertain. Among those, three genes, AKT3, HNRNPU and ZBTB18 are highly ex