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Temporal pathway analysis of cerebrospinal fluid proteome in herpes simplex encephalitis

Objectives: We examined the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) during the course of the disease, in relation to anti-N-methyl-D-aspartate receptor (NMDAR) serostatus, corticosteroid treatment, brain MRI and neurocognitive performance. Methods: Patients were retrospectively included from a previous prospective trial with a pre-specified CSF sampl

Umbilical cord clamping in the early phases of the COVID-19 era - A systematic review and meta-analysis of reported practice and recommendations in guidelines

OBJECTIVES: In the beginning of the COVID-19 pandemic, delayed umbilical cord clamping (CC) at birth may have been commonly discouraged despite a lack of convincing evidence of mother-to-neonate SARS-CoV-2 transmission. We aimed to systematically review guidelines, reports of practice and to analyze associations between timing of cord clamping and mother-to-neonate SARS-CoV-2 transmission during t

Whole-genome Analysis Reveals Contrasting Relationships Among Nuclear and Mitochondrial Genomes Between Three Sympatric Bat Species

Understanding mechanisms involved in speciation can be challenging, especially when hybridization or introgression blurs species boundaries. In bats, resolving relationships of some closely related groups has proved difficult due subtle interspecific variation both in morphometrics and molecular data sets. The endemic South American Histiotus bats, currently considered a subgenus of Eptesicus, har

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to target underlying pathophysiological mechanisms. The DNA repair protein 8-oxoguanine DNA glyc

SCA-LDPC : a code-based framework for key-recovery side-channel attacks on post-quantum encryption schemes

Whereas theoretical attacks on standardized crypto primitives rarely lead to actual practical attacks, the situation is different for side-channel attacks. Improvements in the performance of side-channel attacks are of utmost importance.In this paper, we propose a framework to be used in key-recovery side-channel attacks on CCA-secure post-quantum encryption schemes. The basic idea is to construct

Survey data of public awareness on climate change and the value of marine and coastal ecosystems

The long-term provision of ocean ecosystem services depends on healthy ecosystems and effective sustainable management. Understanding public opinion about marine and coastal ecosystems is important to guide decision-making and inform specific actions. However, available data on public perceptions on the interlinked effects of climate change, human impacts and the value and management of marine and

Adequate Legal Protection and Good Administration in EU Asylum Procedures: H.N. and beyond

The current European situation is marked by an ongoing migration crisis. On a daily basis we are informed of the ever-increasing number of migrants trying to reach Europe’s border – too often with fatal results. The European Court ofJustice, once described as “tucked away in the fairyland Duchy ofLuxembourg”, is today faced with difficult legal questions concerning EU asylum law – the present case