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A treatment planning study of the potential of geometrical tracking for intensity modulated proton therapy of lung cancer

Background. Proton therapy of lung cancer holds the potential for a reduction of the volume of irradiated normal lung tissue. In this work we investigate the robustness of intensity modulated proton therapy (IMPT) plans to motion, and evaluate a geometrical tumour tracking method to compensate for tumour motion. Material and methods. Seven patients with a nine targets with 4DCT scans were selected

Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guerin (BCG) in Eurocine L3 adjuvant protects against tuberculosis

The current live attenuated vaccine against tuberculosis, BCG, poses a risk of disseminated infections in immunocompromised subjects. Therefore, in this study we compared the protective effect of a heat-killed bacille Calmette-Guerin (H-kBCG) vaccine given in a new adjuvant (Eurocine L3) with the protection provided by the conventional live attenuated BCG vaccine in mice (C57BL/6 and BALB/c) chall

Detection of atmospheric species and dynamics in the bloated hot Jupiter WASP-172 b with ESPRESSO

Context. The population of strongly irradiated Jupiter-sized planets has no equivalent in the Solar System. It is characterised by strongly bloated atmospheres and large atmospheric scale heights. Recent space-based observations of SO2 photochemistry have demonstrated the knowledge that can be gained about Earth's uniqueness from detailed atmospheric studies of these unusual planets. Aims. Here we

Unstable Grounds: Reconfigurations of Performance and Politics

Critical StagesUnstable Grounds: Reconfigurations of Performance and PoliticsSpecial Issue, June 2021Gigi Argyropoulou and Stefanie SachsenmaierThis issue explores operations of performance during unstable conditions marked by socio-political, environmental, economic and further challenges. It is particularly interested in histories, reconfigurations and mutations of performance practice as it see

Innovative three-dimensional models for understanding mechanisms underlying lung diseases : powerful tools for translational research

Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably causing decreased breathing capacity and quality of life for patients. While animal models have paved the way for our understanding of pathobiology and the development of therapeutic strategies for disease management, their translational capacity is limited. There is, therefore, a well-recognised need for in