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Background: Certain species from the normal respiratory tract microbiota have recently been proposed to positively influence human health. Corynebacterium propinquum and C. pseudodiphtheriticum (Corynebacteria) are two Gram-positive species that frequently colonize the upper respiratory tract and strongly associate with a reduced incidence of respiratory tract infections. The specific role of Cory

Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis keeps it unresolved. Here, we deploy a high-resolution, 3D ECM mapping method and design a machine-learning powered pipeline to detect and characteri

Gross primary production (GPP) of the vegetation is the largest carbon exchange process of the global carbon cycle. Currently, within satellite-based remote sensing, GPP is generally modelled using linear light use efficiency models where GPP is related to photosynthetically active radiation absorbed by the green vegetation (APAR). These models work well on moderate to low spatiotemporal averaging

Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se

Background: Self-rated health (SRH) is an international measure and indicator of mortality and morbidity that can be used as a mortality predictor in adulthood. This study aimed to examine the status of SRH among adults in Qazvin Province and its relationship with physical activity levels and demographic factors in primary care centers. Methods: This is a cross-sectional study. We included data fr

Heart failure (HF) is a complex clinical syndrome characterized by exercise intolerance. However, most diagnostic assessments are performed at rest, when many patients are asymptomatic. To better understand the underlying pathophysiology, examination during exercise is needed. Hydraulic force, a newly identified mechanism of diastolic filling, is proportional to the difference in short-axis areas

Non-invasive methods for measuring thermal tolerance and thermoregulation in large numbers of individuals under natural environmental conditions are useful to understand the capacity of species to adapt to future climate scenarios. Infrared thermography (IRT) is one such tool in research on thermal adaptation, but concerns have been raised about its reliability, specifically the correlation betwee

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has