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Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer

We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with di

Species recognition through wing interference patterns (WIPs) in Achrysocharoides Girault (Hymenoptera, Eulophidae) including two new species

Wing interference patterns (WIPs) are shown to be an important tool for species recognition in the genus Achrysocharoides Girault (Hymenoptera: Eulophidae). This is demonstrated by combining information from two previously published papers, comprising two cases of cryptic species, and by new material including the description of two new species, A. maieri and A. serotinae from North America. The c

Antimicrobial peptides: key components of the innate immune system

Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant strains. Antimicrobial peptides (AMPs) form an ancient type of innate immunity found universally in all living organisms, providing a principal first-line of defense against the invading pathogens. The unique

A new upper Middle Ordovician-Lower Silurian drillcore standard succession from Borenshult in Ostergotland, southern Sweden: 2. Significance of delta C-13 chemostratigraphy

A total of 239 isotope samples are used for establishing the delta C-13 chemostratigraphy in the upper Middle Ordovician to Lower Silurian succession in the approximately 70 m long Borenshult drillcore. The study interval starts in the upper Darriwilian Furudal Limestone and ends in the Rhuddanian Motala Formation. Four named delta C-13 excursions are recognized in 3-4 formations, namely the Gutte

Selection of packaging systems in supply chains from a sustainability perspective – the case of Volvo

The purpose of this article is to develop an evaluation model for the selection of packaging systems in supply chains from a sustainability perspective. A theoretical evaluation model for comparing cost efficiency and the environmental impact of packaging systems in supply chains are developed from literature. The model is tested in a case study of a supply chain involving Volvo Car Corporation a

SRC is a signaling mediator in FLT3-ITD-but not in FLT3-TKD-positive AML

Mutations of Fms-like tyrosine kinase 3 (FLT3) are among the most frequently detected molecular abnormalities in AML patients. Internal tandem duplications (ITDs) are found in approximately 25% and point mutations within the second tyrosine kinase domain (TKD) in approximately 7% of AML patients. Patients carrying the FLT3-ITD but not the FLT3-TKD mutation have a significantly worse prognosis. The