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OBJECTIVE: Hyperglycemia is a recognized risk factor for cardiovascular disease in diabetes. Recently, we reported that high glucose activates the Ca(2+)/calcineurin-dependent transcription factor nuclear factor of activated T cells (NFAT) in arteries ex vivo. Here, we sought to determine whether hyperglycemia activates NFAT in vivo and whether this leads to vascular complications. METHODS AND RES

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We oppose the opinion that the intra-arterial administration of iodine-based contrast media (CM) appears to pose a greater risk of contrast medium-induced nephropathy (CIN) than intravenous administration since 1) in intra-arterial coronary procedures and most other intra-arterial angiographic examinations, CM injections are also intravenous relative to the kidneys, 2) there is a lack of comparati

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The PFS-16 is a 16-item fatigue scale for Parkinson's disease (PD) developed in the UK. However, documented translations and psychometric evaluations are sparse. Aim -  To translate the PFS-16 into Swedish and conduct initial testing of its psychometric properties. Methods -  Following translation, the PFS-16 was administered twice (2 weeks apart) to 30 people with PD (18 men; mean age/PD duration

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The single Trp of human cystatin C, Trp-106, is located in the second hairpin loop of the proteinase binding surface. Substitution of this residue by Gly markedly altered the spectroscopic changes accompanying papain binding and reduced the affinity for papain, actinidin, and cathepsins B and H by 300-900-fold. The decrease in affinity indicated that the side chain of Trp-106 contributes a similar

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Popular Abstract in Swedish EG-fördragets regler om varors fria rörlighet är ett centralt område inom de Europeiska gemenskapernas rättsordning. Detta rättsområdet har stor betydelse i det praktiska rättslivet, såväl för offentlig förvaltning som för enskilda företag. I denna bok behandlas spörsmål rörande EG-fördragets regler om icke-tariffära handelshinder (artiklarna 30, 34 och 36). Ända sedanThis thesis concerns the Articles 30, 34 and 36 of the EC-Treaty and conflicts of competence between the Community and the Member States. It deals especially with the delimitation between community concerns and national concerns in the field of non-tariff barriers to trade in community law. A new perspective concerning the application of Articles 30 and 34 of the EC-Treaty is introduced. It is arg

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The purpose of this study is to investigate the process of international commercial arbitration and its development as a legal and cultural entity. The recent changes within the field of arbitration are intimately related to the intensification of global exchanges and the growth of “world society”. It follows that any sociological study of arbitration must be conducted in light of the on-going glo

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Popular Abstract in Swedish Fetma är ett ökande problem i många delar av världen eftersom det leder till en ökad risk för sjukdomar såsom typ 2 diabetes (åldersdiabetes) och hjärtkärlsjukdomar. Anledningen till att fetma ökar är det stillasittande liv som många lever idag i kombination med en alltför kaloririk kost. Flera studier har visat att ett ökat intag av fett inducerar fetma. Detta kan ha f

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The artificial neural network (ANN) methods are introduced (mainly for calculation of thermal and hydraulic coefficients) into a computer-aided design code of compact heat exchangers (CCHE). CCHE integrates the optimization, database, and process drawing into a software package. In the code, a strategy is developed for the optimization of compact heat exchangers (CHEs), which is a problem with cha

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This thesis considers a class of cooperative n-person games (voting games) in which the voters are spread across an ideological scale. The two most commonly used measures of individual voting power in voting games are the Shapley-Shubik index and the Banzhaf-Coleman index. In both indices, the actors are assumed anomymous and treatad symmetrically. That is, the indices do not take into account tha