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NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning.

Recombinant adeno-associated viral (rAAV) vector-induced neuropeptide Y (NPY) overexpression in the hippocampus exerts powerful antiepileptic and antiepileptogenic effects in rats. Such gene therapy approach could be a valuable alternative for developing new antiepileptic treatment strategies. Future clinical progress, however, requires more detailed evaluation of possible side effects of this tre

Cerebellar inhibition of inferior olivary transmission in the decerebrate ferret.

Elderly women's experiences of living with fall risk in a fragile body: a reflective lifeworld approach

The purpose of this qualitative study was to explore the lived experience of fall risk from a lifeworld perspective in elderly women with previous fragility fractures. Thirteen elderly women with a high risk of fall and fracture, aged 76-86, living in their own homes in rural areas, were recruited from a voluntary fracture prevention programme. All women had a history of fragility fractures and we

Long-term follow-up and consequences for severe road traffic injuries - treatment costs and health impairment in Sweden in the 1960s and the 1990s

The purpose of this study is to provide information from two prospective long-term follow-ups for severe road traffic injuries in Sweden. The long-term consequences, in terms of loss of health and costs of care, are presented for severe injuries in Sweden in the early 1990s and are compared with information on injury severity and health care utilisation 25 years ago. The follow-up in the 1990s sho

Muscular rest and gap frequency as EMG measures of physical exposure: the impact of work tasks and individual related factors

Phase Behavior in Aqueous Two-Phase Systems Containing

Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer

OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis

Ready-made matrix-assisted laser desorption/ionization target plates coated with thin matrix layer for automated sample deposition in high-density array format.

Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function

Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)

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Chronic diseases (CD) represent the main cause of mortality in developed countries. The increase in the prevalence of of CD is associated with changes in lifestyle habits, including those related to the consumption of processed foodstuffs. In these foods advanced glycation end products (AGE) and advanced lipoperoxydation products (ALE) are formed as a consequence of the reactivity of proteins, car

Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxynorvaline and its use in immunological studies

Prognostic implications of various models for calculation of S-phase fraction in 259 patients with soft tissue sarcoma

Ten years of AFLP in ecology and evolution: why so few animals?

Researchers in the field of molecular ecology and evolution require versatile and low-cost genetic typing methods. The AFLP (amplified fragment length polymorphism) method was introduced 10 years ago and shows many features that fulfil these requirements. With good quality genomic DNA at hand, it is relatively easy to generate anonymous multilocus DNA profiles in most species and the start-up time

A modified Anderson-Wilkins electrocardiographic acuteness score for anterior or inferior myocardial infarction.

Occupational exposure to NDMA and NMor in the European rubber industry

Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherland

Rapid and specific detection of Salmonella spp. in animal feed samples by PCR after culture enrichment

Tissue microarray is inappropriate for analysis of BCL6 expression in diffuse large B-cell lymphoma.

The factor H variant associated with age-related macular degeneration (H384) and the non-disease associated form bind differentially to C-reactive protein, fibromodulin, DNA and necrotic cells.