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Strategies for Miniaturized Biomarker Detection

Popular Abstract in Swedish Prostatacancer är en av de vanligaste förekommande cancerformerna. Många äldre män har cancerceller i sin prostata, men som tur är behöver inte all cancer behandlas eftersom den inte växer. I USA får ungefär 27% av alla män prostatacancer och cirka 10% dör av det. Vi har utvecklat en ny miniatyriserad metod för att påvisa prostatacancer (Paper I). Genom att titta på PSA

Planetesimal and Protoplanet Dynamics in a Turbulent Protoplanetary Disk: Ideal Unstratified Disks

The dynamics of planetesimals and planetary cores may be strongly influenced by density perturbations driven by magneto-rotational turbulence in their natal protoplanetary gas disks. Using the local shearing box approximation, we perform numerical simulations of planetesimals moving as massless particles in a turbulent, magnetized, unstratified gas disk. Our fiducial disk model shows turbulent acc

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Stress-related peptides in suicide attempters

Popular Abstract in Swedish Det är välkänt att patienter som har gjort ett suicidförsök löper en ökad risk att i framtiden ta sitt liv. I de flesta fall görs suicidförsök av individer som på något sätt är utsatta för stress. Stress kan orsakas av en psykisk eller fysisk sjukdom. Psykosociala faktorer, såsom en skilsmässa eller en annan ohållbar situation i hemmet eller på arbetet, kan också förors

Modelling the gold market, explaining the past and assessing the physical and economical sustainability of future scenarios

By using an integrated dynamic model we are able to reconstruct the supply and gold price of the past (1920-2010) and this is used to predict the future supply of gold to the market and to make a forecast of the goldprice 2010-2100. The model was validated against field data for the period 1920-2010 and it performs well. The model GOLD is implemented in the STELLA® software and the model described

Driving Forces of Supplier Integration - A Case Study from the Grocery Industry

The focal company in this study is establishing a partnership style of’ relationships with a few selected suppliers. The article focuses on the driving forces behind such an initiative. It attempts to answer the questions why this company is trying to develop a closer working relationship with one of the selected suppliers, the supplier of corrugated board. The purpose of the article is thus to an

A World of Tropes?

Abstract in UndeterminedWhy should one hold that the world is a world of tropes? Or, more generally: How do we justify our ontological conclusions? It seems clear that the only evidence at our disposal must belong to appearances. For a realist, however, it is unreasonable to think that our conceptualisation of reality will reveal to us reality as it is independently of how it seems. You simply can

Genetics of Osteoporosis - Studies on bone size, structure and strength in the rat

Osteoporosis is characterized by decreased bone mineral density (BMD) leading to reduced bone strength and increased fracture risk. Several heritable components affect a bone’s ability to resist fracture, including size, structure and strength; therefore identification of the genes underlying several bone characteristics will help elucidate the pathogenesis of fracture risk. Dissection of the gene

The use of modelling and simulation approach in reconstructing past landscapes from fossil pollen data: a review and results from the POLLANDCAL network

Information on past land cover in terms of absolute areas of different landscape units (forest, open land, pasture land, cultivated land, etc.) at local to regional scales is needed to test hypotheses and answer questions related to climate change (e.g. feedbacks effects of land-cover change), archaeological research, and nature conservancy (e.g. management strategy). The palaeoecological techniqu

Ionic charge, radius, and potential control root/soil concentration ratios of fifty cationic elements in the organic horizon of a beech (Fagus sylvatica) forest podzol

The root/organic soil concentration ratio; R/S) of 50 cationic mineral elements was related to their ionic properties, including ionic radius (r), ionic charge (z), and ionic potential (z/r or z(2)/r). The materials studied were ectomycorrhizal beech (Fagus sylvatica L.) roots and their almost purely organic soil substrate, the O-horizon (mor; raw humus) of a Podzol in South Sweden, developed in a

Neutron guide-split: A high performance guide bundle concept for elliptical guides

We present a new guide-split concept for transporting cold and thermal neutrons to multiple instruments from a single beam port at a neutron facility without compromising the useful neutron brilliance notably for any of the instruments. Elliptical guides are capable of transporting an almost completely filled phase space within a large divergence (+/- 2 degrees for cold neutrons). It is therefore