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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/2024-08/publication%20in%20Science%20Advances.pdf - 2026-07-04

Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts Delayed Recovery of Movement-Related Cortical Function in Parkinson’s Disease after Striatal Dopaminergic Grafts Paola Piccini, MD,* Olle Lindvall, MD, PhD,† Anders Björklund, MD, PhD,‡ Patrik Brundin, MD, PhD,§ Peter Hagell, RN, BSc,† Roberto Ceravolo, MD,* Wolfgang Oertel, MD,i Niall

https://www.wnc.lu.se/sites/wnc.lu.se/files/piccini_et_al_ann_neurol_2000_0.pdf - 2026-07-04

Popular Abstract in Swedish Cytokrom P450 är en stor enzymfamilj som finns i alla levande organismer och tar del i både endogen och exogen metabolism. De är primärt mono-oxygenaser och utför en stor mängd reaktioner. Till skillnad från många andra enzymer har de blivit optimerade för att kunna reagera med många olika substrat, istället för att ha höga reaktionshastigheter. I det aktiva sätet har dThe cytochromes P450 are a large enzyme family that is found in all living organisms and takes part in both endogenous and exogenous metabolism. They are primarily mono-oxygenases and perform a wide range of reactions. In contrast to many other enzymes, they have been optimised to react with a wide range of substrates instead of having high reaction rates. In the active site, these enzymes have a

Popular Abstract in Swedish 75% av alla kemiska reaktioner sker på en yta av något slag. En av anledningarna till detta är att många ytor har en katalytisk effekt. Inom kemins värld är en katalysator något som påskyndar en kemisk reaktion utan att själv förbrukas, och ett tydligt exempel på en katalytiskt aktiv yta är en bilkatalysator, vilken i princip består av en varm metallyta. På denna yta omThis work deals with interpretation of experimental surface spectroscopic data with the aid of first-principle calculations. Surface infrared reflection-absorption spectra as well as spectra from the electron spectroscopic methods photoemission and X-ray absorption are considered. In all cases the surface is modeled by a metal cluster with the same (frozen) geometry as part of the surface. The wo

This work is the first comprehensive description of Makalero, a language spoken by approximately 6,500 speakers in the Iliomar subdistrict, in the south-east of the Republic of East Timor. While previous sources considered it to be a dialect of the larger language Makasae, the present study, which is based on primary data gathered by the author during fieldwork in East Timor, notes sufficient gram

Popular Abstract in Swedish Cytokromer bär hem som prostetisk grupp och ingår i den energi givande andningskedjan. Cytokromer namnges beroende på strukturen av den hem-molekyl som respektive cytokrom bär. Cytokrom av a-typ innehåller hemA, cytokrom av b-typ innehåller hemB osv. Cytokrom av c-typ skiljer sig från övriga cytokrom genom att ha hemgruppen kovalent bunden till proteinet. Syntes av baktCytochromes function in electron transfer reactions, e.g. in respiratory systems, and contain haem as a prosthetic group. Cytochromes of the c-type differ from other cytochromes in that haem is covalently attached, via thioether linkages, to two cysteine residues in a conserved sequence motif in the protein, Cys-Xaa-Yaa-Cys-His. The functional location of c-type cytochromes in bacteria is on the o

Popular Abstract in Swedish En kontinuerlig alkoholkonsumtion leder till en ökad tolerans för alkohol (dvs en allt större dos krävs för att uppnå samma effekt) och kan slutligen också leda till ett alkoholberoende. Alkoholism är ett betydande samhällsproblem och en personlig tragedi för de som drabbas och deras omgivning. Alkohol har till skillnad från andra beroendeframkallande droger som tex koAlcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. AP-1 induces gene expression of genes having a functional AP-1 bi

Popular Abstract in Swedish Olika aspekter angående transportmekanismen för aminosyran L-dopa in i så kallade Langerhans celler (LC) i människans överhud och överhudens energimetabolism är undersökta och karaktäriserade. LC har flera olika funktioner i huden, och är en av de mest perifera delarna i vårt immunsystem mot omvärlden. Cellerna vandrar ut i huden från blodkärlssystemet. Cellerna kan äveBased on the discovery of a new amino acid transport system in Langerhans cells (LC), various aspects concerning the L-dopa uptake mechanism into human epidermal LC and the energy metabolism of epidermis have been examined and subsequently characterised. The system lacks any characteristics of other described amino acid transport systems in other cell types. The Falck/Hillarp histofluorescence met

Den dömande verksamheten är en av samhällets mest ingripande former av maktutövning. För att allmänheten ska ha förtroende för denna verksamhet krävs att den framstår som objektiv och därmed legitim. Med utgångspunkt i olika typer av kritik, som förts fram inom såväl den massmediala debatten som den mer rättsinterna aktualiseras frågor om objektivitet och rättstillämpningens legitimitet. FörfattarThe adjudication process is one of society’s most intrusive forms of power. To maintain the general public’s confidence in the judiciary, it is crucial that the judicial activities are perceived as being conducted objectively and hence legitimately. Criminal trials have been subjected to scrutiny and criticism of various kinds in the media as well as in internal debates within the legal discipline

Purpose of this paper The purpose of this paper is to develop an evaluation model comparing a one-way with a returnable packaging system from a supply chain perspective. Design/methodology/approach A theoretical evaluation model for comparing cost efficiency and environmental impact of one-way and returnable packaging systems in supply chains is developed from literature. The deducted model is su

Popular Abstract in Swedish Septisk shock (shock utlöst av blodförgiftning) är en potentiellt dödlig komplikation till infektion med bakterier eller andra mikroorganismer. Inte bara de infekterande organismerna i sig, men också de inflammatoriska system och signalsubstanser som aktiveras, orsaker ett generaliserat inflammatoriskt tillstånd. Om obehandlat, kan detta leda till att ett eller flera or

The administration’s legitimacy of the constitutional democracy consist in laws being applied in accordance with the principles which are their foundation. Care about the elderly is the municipals’ responsibility, and this task is regulated in the law of social services and the law of health and healthcare. The legislation grant individual elderly the right to a standard of living that in the law

Popular Abstract in Swedish Inflammation is a protective response against injury or infection (the invading microbes or their toxins) with the aim being the removal of causal agent followed by the repair process. Without inflammation, infections would go unchecked and wounds would not heal. However, inflammation is like a double-edged sword. Though it is mainly a protective response, some times, i

Reduced urinary bladder capacity is a clinically significant problem. The surgical methods that have been available to treat this, such as urinary diversion or surgically augmenting the bladder by incorporation of intestinal segments, all have serious drawbacks. There is a need to understand how the smooth muscle of the intestine and bladder can interact when brought into close contact surgically,

Renewable energy will play an important role in the transition to a sustainable energy system. With an increased maturity of renewable energy technologies, issues concerning implementation are becoming more important. The decisions and actions of municipalities and other local actors have a significant influence on the implementation of renewable energy. In this thesis challenges to implementation

Popular Abstract in Swedish För att en multicellulär organism som männinskan ska kunna fungera måste celldelningen strikt kontrolleras. Protein som reglerar celldelning på cellulär nivå kallas för "tillväxtfaktorer". Vi har studerat ett sådant protein som kallas för transforming growth factor-beta (TGF-b). Namnet TGF-b kommer sig utav att detta protein kan transformera (omvandla) epiteliala njurceTransforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. The costimulatory effect depends on the presence of monocytes and is mediated by these cells. Furthermor

Popular Abstract in Swedish Människan har under mycket lång tid använt enzymer vid tillverkning av livsmedel, bland annat vid syrning av mjölk, jäsning av bröd och bryggning av öl och vin. Man använde sig då av hela levande organismer och först på slutet av 1800-talet kunde den aktiva substansen isoleras. Dessa aktiva substanser fick samlingsnamnet enzym, vilket kommer från grekiska och betyder "iThe influence of different reaction parameters on enzyme selectivity was investigated. The reaction conditions studied were solvent dependence, water activity and reaction temperature. The improved selectivity was observed as higher synthetic yields in a-chymotrypsin and subtilisin catalyzed peptide synthesis respectively, and as higher enantioselectivity in the asymmetric reduction of ketones cat