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The advent of PET ligands that bind tau pathology has enabled the quantification and visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong evidence from neuropathologic studies that the most widely used tau PET tracers (i.e., 18F-flortaucipir, 18F-MK6240, 18F-RO948, and 18F-PI2620) bind tau aggregates formed in AD in the more advanced (i.e., ≥IV) Braak stages. Howe
The global temperature rise is proportional to the cumulative amount of CO2 emissions to the atmosphere. This observation is consistent between climate models and historical observations. It has also given rise to the concept of a carbon budget, which sets a threshold for the amount of CO2 that can be emitted into the atmosphere while still fulfilling political goals such as the Paris Agreement.Te
The introduction of total prostate-specific antigen (tPSA) testing in serum has revolutionized the detection and management of men with prostate cancer. This review will highlight some of the exciting new developments in the field of prostate cancer screening in general and from our SPORE research program at Memorial-Sloan Kettering Cancer Center. First, it is important to understand that the inhe
Popular AbstractI början på 1990-talet drabbades Sverige av en mycket djup ekonomisk kris. Den svenska nittiotalskrisen uppfattades inte som en tillfällig konjunkturnedgång utan som symptom på grundläggande systemfel i Sveriges ekonomi. Många bedömare menade att den s.k. svenska modellen med stor välfärdsstat och höga skatter hade försämrat marknadsekonomins effektivitet och gjort att Sverige undeIn the early 1990s, Sweden was hit by a profound economic crisis. The Swedish crisis of the nineties was not perceived as a temporary recession, but rather as a fundamental and systemic fault in Swedish economy. Many commentators held that the Swedish model with a large welfare state and high taxes had impaired Sweden's economic performance. The aim of this thesis is to empirically assess the hypo
Constrained by national tests and the mathematics curriculum, teachers have problems finding time for exploratory and hands-on mathematical activities, especially so in classes with a reduced pace of progression, for example because of a large proportion of second-language learners. Could the leisure-time center, where time is not earmarked, provide such opportunities? The conclusion of this thesi
Popular AbstractI avhandlingen undersöks den ekonomiska omvandlingsprocess som skett i Sverige sedan mitten av 1970-talet. Av speciellt intresse är hur och varför de fördelar som företag och branscher åtnjuter på grund av samlokalisering med andra ekonomiska aktörer (så kallade agglomerationsexternaliteter) varierar över olika faser av ekonomisk omvandling. Avhandlingen baserar sig på de framsteg This thesis investigates the process of economic transformation taking place in Sweden since the mid 1970s. Especially, it is concerned with how and why benefits that firms and industries draw from regional co-location with other actors (agglomeration externalities) vary over stages of economic transformation. Drawing on recent findings within the fields of evolutionary economics and evolutionary
We present and discuss new determinations of metallicity, rotation, age,kinematics, and Galactic orbits for a complete, magnitude-limited, andkinematically unbiased sample of 16 682 nearby F and G dwarf stars. Our∼63 000 new, accurate radial-velocity observations for nearly 13 500stars allow identification of most of the binary stars in the sampleand, together with published uvbyβ photometry, Hipp
Organ transplantation provides a treatment of end-stage disease primarily in the kidney, liver and heart. The immunosuppressive treatment regimens of today efficiently prevent early acute rejection; however the long-term survival has not improved to the same extent. Within months/years the majority of transplanted organs develop chronic allograft dysfunction (CAD), associated with fibrosis and int
This thesis explores the use of data mining and AI-tailored frameworks for extracting public health evidence from large health datasets. The research presented in this thesis demonstrates the potential of these tools for automating and simplifying the data mining process, and for providing valuable insights into various public health issues.In Paper I, we used data mining and natural language proc
Background: Voluntary self-exclusion from gambling is a common but underdeveloped harm reduction tool in the management of gambling problems or gambling disorders. Large-scale, multi-operator, and operator-independent self-exclusion services are needed. A recent nationwide multi-operator self-exclusion service in Sweden (Spelpaus), involving both land- and web-based gambling sites, is promising, b
Packaging serves a lot of purposes, and would be hard to do without. Packaging protects the goods during transport, saves costs, informs about the product, and extends its durability. A transport package is required to be strong and lightweight in order to be cost effective. Furthermore, it should be recycled because of environmental and economical concerns. Corrugated board has all of these featu
Popular Abstract in Swedish Ny kunskap gör det möjligt att med hjälp av DNA-information välja ut vilka kvigor/kor som förväntas ge en hög mjölkavkastning, höga halter av mjölkens komponenter och optimala egenskaper för ostproduktion. Denna information kan användas för att bättre anpassa mjölkens sammansättning och processegenskaper med de svenska mejeriernas behov för att på så vis förbättra mjölkMilk genomics is a new area of research that explores the relations between cow genetics and milk characteristics. Identifying the genes controlling compositional and technological traits of milk will give opportunities to select cows for targeted milk production. In this thesis, the impact of different genetic approaches, i.e. quantitative genetic evaluation, single gene effects and genomic selec
