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Predicting hydrodynamic forces from ship waves along a waterway is essential for managing a sustainable shoreline in fairways. In this context, a numerical model can be a useful tool for calculating ship waves in fairways with complex geometry. XBeach is a numerical model offering the potential to be a one-tool solution for simulating ship waves from the ship to the shore. However, XBeach has not

Purpose: The purpose of this paper is to contribute to a better understanding of the occurrence of strategic error in using key performance indicators (KPIs) in innovation Design/methodology/approach: This case study was conducted at the innovation department of an organization in the process industry that operates production sites and sales organisations worldwide. Observations and interviews wer

The semiconductor technology has enabled the fabrication of integrated circuits (ICs), which may include billions of transistors and can contain all necessary electronic circuitry for a complete system, so-called System-on-Chip (SOC). In order to handle design complexity and to meet short time-to-market requirements, it is increasingly common to make use of a modular design approach where an SOC i

Nonlinear pulse post-compression, mainly enabled by self-phase modulation (SPM), opens new avenues towards high peak power laser pulses at high average power while bypassing the need for a gain medium with large bandwidth. However, SPM-induced spectral broadening typically introduces spectral amplitude modulations as well as a chirp of third and higher orders, limiting the temporal contrast of the

We consider the problem of variable selection in high-dimensional settings with missing observations among the covariates. To address this relatively understudied problem, we propose a new synergistic procedure—adaptive Bayesian SLOPE with missing values—which effectively combines SLOPE (sorted l 1 regularization) with the spike-and-slab LASSO (SSL) and is accompanied by an efficient stochastic ap

Background:Esophageal atresia (EA) is a congenital malformation affecting 1:3000-4500 newborns. Approximately 15% have a long-gap EA (LGEA), in which case a primary anastomosis is often impossible to achieve. To create continuity of the esophagus patients instead have to undergo lengthening procedures or organ interpositions; methods associated with high morbidity and poor functional outcomes. Eso

Active vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], plays a pivotal role in calcium homeostasis and bone metabolism. Circulating levels of 1,25(OH)(2)D(3) are thought to be dependent mainly on the activity of the renal cytochrome P450 enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), which is potently induced by PTH. However, 1alpha-hydroxylase activity or expressi

It is now widely speculated that life originated at the "Black Smokers" of the undersea hydrothermal vents, where conditions exist for the formation of the primary ingredients and their subsequent transformation to higher biotic species such as amino acids, alcohols, etc. Any possible routes for the prebiotic oligomerization of simple compounds like amino acids, necessary for cell formation, has s

Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods:

Many industries have benefited from modularisation; while in the architecture, engineering and construction (AEC) industry, the concept of modularisation is associated with dimensional coordination. This has added to an already extensive list of challenges due to market size and the concept of economies of scale in AEC industry, to name but a few. Moreover, there is a myth that the AEC industry is