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Some of the best compression ratios for text compression are provided by the PPM (prediction by partial matching) class of algorithms. These algorithms are based on arithmetic coding using a fixed-depth Markov chain model of the source, i.e., the subsequence of symbols generated in any state s of the source is assumed to be the output of a memoryless subsource w=w(s). One of the most crucial steps
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High-dose methotrexate (HDMTX) is a central component in the treatment of acute lymphoblastic leukemia, osteosarcoma, and some lymphomas and brain tumors. MTX is given at lethal doses and then is followed by rescue treatment with folinic acid (FA). Despite FA rescue, many patients suffer severe toxicity. The pharmacokinetics of FA rescue have not been sufficiently studied. However, optimization of
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Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of pat
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Airborne emissions from disc brakes adversely affect the air quality in urban areas of EU. The emissions come from the wear of the pads and rotors in disc brakes. The wear of disc brakes depends on the contact situation between the pads and rotors. During braking, secondary contact plateaus are created on both the pads and rotors contact surfaces. Literature reports numerical studies of the creati
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Tunnel fire risk analysis are a useful tool to ensure adequate safety levels in tunnels. This report presents the work conducted to integrate a multi-zone modelling approach into a fire risk assessment tool, called ARTU. This work was performed to improve its fire modelling predictive capabilities compared to the currently adopted 1D fire modelling representation. This is deemed to allow for the u
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Since Pakistan is vulnerable to changing climatic conditions, the country needs emergency measures at every level to mitigate their effect. Many studies have addressed Corporate Social Responsibility (CSR) at the macro or institutional level, but its effect at the micro-level is largely ignored in the contemporary literature. The present study aims at filling this gap by highlighting the role of m