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Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. Despite improved recognition of drug-related side effects on mitochondrial function
Diesel engines are by far the most common means of propulsion aboard ships. It is estimated that around half of their fuel energy consumption is dissipated as low-grade heat. The organic Rankine cycle technology is a well-established solution for the energy conversion of thermal power from biomass combustion, geothermal reservoirs, and waste heat from industrial processes. However, its economic fe
Although continuous production processes are often desired, many processing industries still work in batch mode due to technical limitations. Transitioning to continuous production requires an in-depth understanding of how each unit operation is affected by the shift. This contribution reviews the scientific understanding of similarities and differences between emulsification in turbulent rotor-st
A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabet
This population-based time-trend study examines gun violence rates among males in Sweden during the years 1996 to 2015 and compares the rate in Sweden to other Western European countries. Data were collected from six registries and are presented descriptively per 100,000 inhabitants. The risks among males in Sweden increased considerably in both lethal and non-lethal gun victimization and perpetra
In the last century, starch present in foods was considered to be completely digested. However, during the 1980s, studies on starch digestion started to show that besides digestible starch, which could be rapidly ors lowly hydrolysed, there was a variable fraction that resisted hydrolysis by digestive enzymes. That fraction was named resistant starch (RS )and it encompasses those forms of starch t
Deuteration of biomolecules has a major impact on both quality and scope of neutron scattering experiments. Cholesterol is a major component of mammalian cells, where it plays a critical role in membrane permeability, rigidity and dynamics, and contributes to specific membrane structures such as lipid rafts. Cholesterol is the main cargo in low and high-density lipoprotein complexes (i.e. LDL, HDL
New diamagnetic nickel(II) complexes based on an unsymmetrical (1-(3-((ditert-butylphosphino)methyl)phenyl)-N,N-dimethyl-methanamine) (PCN) pincer ligand were synthesized and characterized by 1H, 31P{1H}, and 13C{1H} NMR spectroscopy. Their molecular structures were confirmed by X-ray diffraction. Oxidation to high-valent paramagnetic Ni(III) dihalide complexes was achieved through straightforward
Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when
This paper assesses the effect of the Russo–Georgian conflict of 2008 and the Ukrainian–Russian conflict of 2014 on the well-being of minorities in Russia. Using the Russian Longitudinal Monitoring Survey (RLMS), we find that the well-being of Georgians in Russia suffered negatively from the 2008 Russo–Georgian conflict. We show that the conflict has no direct effect on the labor market outcomes o
When applying membrane processes on industrial scale in the food industry both the fouling and the subsequent cleaning of the membranes are key but often underestimated factors. This presentation will focus on the impact of pre-treatment, operation conditions and module design on fouling and cleaning.After reviewing the current state-of-the-art of membrane fouling and cleaning in the food industry
