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Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin-like growth factor 1 (IGF1) has proven to be a potent neuroprotective molecule in animal models of age-related neurodegeneration. In
Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. The hypothalamus has emerged as an important area of pathology with selective loss of neurons expressing the neuropeptides orexin (hypocretin), oxytocin and vasopre
The evolutionary dynamics of diurnal Aletis moths (Lepidoptera: Geometridae: Sterrhinae) in the Afrotropics have been obscured by their allopatric distributions, significant inter- and intraspecific variation in adult and caterpillar phenotypes, and involvement in complex mimicry systems. Extensive phenotypic disparity, alongside conserved genital morphology and a lack of suitable material for gen
Essentially all academic research of today relies on analysis of data from a wide range of sources. Several underpinning, and rapidly developing, technologies are supporting the analysis of this data. Visualization serves as an interface to this ecosystem of tools and methods and integrates them into environments supporting scientific workflows, effectively sharing cognitive load between computers
The production of fast pyrolysis bio-oil (FPBO) from secondary biomass is a promising technique for the production of liquid biofuels. However, the resulting FPBO is often viscous and chemically unstable, requiring significant upgrading while also being difficult to work with. To overcome this issue, FPBO can be hydrotreated using slurry hydrotreatment, which has a long history as a processing tec
INTRODUCTION: Left ventricular (LV) longitudinal function is a prognostic marker of hospitalization and mortality in LV dysfunction. Recently, left atrial (LA) reservoir and conduit strain have also been presented as independent prognostic markers. However, the atria and ventricles are coupled in the fibrous atrioventricular plane (LA-LV coupling). The degree to which the LA strain is affected, or
This paper introduces a three-dimensional approach for analysing brokerage in social networks that has the potential to open new areas of research in Science and Technology Studies (STS). Brokerage is a fundamental concept in social network analysis, where it refers to situations in which actors bridge otherwise disconnected actors. Such brokerage can have both individual consequences and conseque
Permanent Magnet Synchronous Motors (PMSMs) are becoming increasingly popular in traction applications. PMSMs have gained popularity due to their efficiency, compactness and excellent features related to control. This is mainly because of the permanent magnet placement in the rotor, which negates any additional rotor excitation, hence reducing energy losses considerably. This makes them more effic
To meet stringent emissions regulations on soot emissions, it is critical to further advance the fundamental understanding of in-cylinder soot formation and oxidation processes. Among several optical techniques for soot quantification, diffuse back-illumination extinction imaging (DBI-EI) has recently gained traction mainly due to its ability to compensate for beam steering, which if not addressed
Practices of care between grandparents, adult children and grandchildren are the hub of intergenerational relationships. To care for an elderly parent, or for a grandchild, is an engagement that can be a necessity coming out of lack of other care providers, or it can be an engagement you voluntarily take upon yourself. It can feel like an obligation, and/or as something you do out of love for your
Background: Involving service users in inpatient care and recovery planning has gained interest worldwide. Our purpose was to evaluate the process of implementation of a coproduced Recovery Guide (RG) intervention in 22 inpatient wards in Sweden, in terms of context, implementation process and mechanisms of impact over 12 months.Methods: A mixed method design and a process evaluation framework wer
