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Atherosclerosis as a disease is postulated to stem from a response to injury of the arterial wall by various stimuli. The inflammatory response is proposed to mediate intimal formation after injury. One pathway of cellular response to injury is through transcription factor NF-kB. We show that balloon injury of rat arteries leads to increased NF-kB activity and ICAM-1 expression, associated with i
Coordinating a software project across distances is challenging. Even without geographical and time zone distances, other distances within a project can cause communication gaps. For example, organisational and cognitive distances between product owners and development-near roles such as developers and testers can lead to weak alignment of the software and the business requirements. Applying good
Popular Abstract in Swedish Alla kemikalier vi använder oss av och utsätter oss för påverkar både oss och den omvärld vi lever i. Under hela sin livscykel har de en påverkan på miljön, från de att man utvinner råmaterialen, när de tillverkas och när vi använder dem. Till och med efter att vi använt dem har kemikalierna en påverkan på miljön. Det gäller både schampot som följer med duschvattnet ut It is of at most importance that society reduces its impact on the environment. In the chemical industry the use of renewable resources will play a fundamental role in the transition to more sustainable chemical products. Also industrial biotechnology, i.e. the use of enzymes to convert raw material into valuable chemicals at low temperatures, leads to more sustainable processes. The research pres
Food engineering aspects of cooking of meat products in relation to their biophysical properties, such as water- and fat-holding, have been reviewed. Moreover, some of the new emerging, mild cooking technologies, such as high pressure and electro-based heating (radio frequency cooking and ohmic heating) have been discussed in relation to the biophysical properties of the meat products treated. The
The prevalence of obesity among children and adolescents is on the rise. The majority of overweight or obese children are treated by primary health care providers including paediatricians, family practitioners, dieticians, nurses, and school health services - and not by specialists. The majority of obese children have no underlying medical disorder causing their obesity yet a significant proportio
Recent advances in biochemistry and drug design have placed proteases as one of the critical target groups for developing novel small-molecule inhibitors. Among all proteases, aspartic proteases have gained significant attention due to their role in HIV/AIDS, malaria, Alzheimer's disease, etc. The binding cleft is covered by one or two β-hairpins (flaps) which need to be opened before a ligand can
