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The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular di

A new fully-integrated concurrent dual band CMOS power amplifier (PA) which covers the first and third channels of IEEE 802.15.3c standard is presented. In order to achieve concurrent operation of the 60 GHz PA in two desired narrow frequency bands, the multi-frequency passive coupling matching networks design is proposed. The full wave electromagnetic analysis (by the conventional Method of Momen

Uterine fibroids are the most common tumors of the uterus and the female pelvis and are associated with substantial morbidity for several women. In women with a wish to preserve fertility, a myomectomy is the surgical procedure of choice when medical therapy is inadequate. Despite evidence that minimally invasive surgery is preferable to laparotomy, most myomectomies are still performed by laparot

The paper addresses a puzzle about the proportionality requirement on self-defense due to L. Alexander. Indirectly the puzzle is also relevant to the proportionality requirement on punishment, insofar as the right to punish is derived from the right to self-defense. Alexander argues that there is no proportionality requirement on either self-defense or punishment, as long as the aggressor/offender

On 25 March 2015, the Enlarged Board of Appeal of the European Patent Office (EBA) finally delivered its’ much awaited decisions on the consolidated referrals G2/12 (“Tomato II”) and G2/13 (“Broccoli II”). The EBA affirmed that products, namely plants or parts thereof, obtained by essentially biological processes are – unlike individual plant varieties – principally patentable under the European P

Structured laser illumination planar imaging (SLIPI) is a technique capable of suppressing multiple light scattering effects in optically dense sprays, resulting in spray images without blurs and with enhanced contrast. The novelty of the work presented in this thesis concerns the applications of a variety of SLIPI-based techniques for the measurement of droplet size, droplet concentration, and li

he North Taymyr ice-marginal zone (NTZ) is a complex of glacial, glaciofluvial and glaciolacustrine deposits, laid down on the northwestern Taymyr Peninsula in northernmost Siberia, along the front of ice sheets primarily originating on the Kara Sea shelf. It was originally recognised from satellite radar images by Russian scientists; however, before the present study, it had not been investigated

Cutting tool spontaneous failure such as, edge fracture and chipping are common phenomena in the metal cutting process, especially when difficult workpiece materials which have poor cutibility are met in the machining process. The tool failures are often caused by high mechanical and thermal stresses acting in it. Monitoring stresses acting in a cutting edge during machining process can provide mo