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Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?

One of the major symptoms of the neurodegenerative condition Parkinson's disease (PD) is a slowness or loss of voluntary movement, yet frustratingly therapeutic strategies designed to restore movement can result in the development of excessive abnormal movements known as dyskinesia. These dyskinesias commonly develop as a result of pharmacotherapy in the form of L-DOPA administration, but have als

Evolving Concept of Small Vessel Disease through Advanced Brain Imaging.

Imaging plays a crucial role in studying and understanding cerebral small vessel disease. Several important findings have emerged from recent applications of advanced brain imaging methods. In patients with acute lacunar syndromes, diffusionweighted MRI studies have shown that the diagnostic precision of using clinical features alone or combined with CT scan findings to diagnose small vessel disea

Symptomatic cluster headache: a review of 63 cases.

Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. Symptomatic cases have been described, for example tumours, dissections and infections, but a causal relationship between the underlying lesion and the headache is difficult to determine in many cases. The proper diagnostic evaluation of cluster headache is an issue unresolved. The literat

Integral Identities for Passive Systems and Spherical Waves in Scattering and Antenna Problems

Popular Abstract in Swedish I avhandlingen presenteras nya teoretiska och experimentella metoder för att analysera spridning av elektromagnetiska vågor, framförallt med fokus på antenner och trådlös kommunikation. Oavsett det handlar om radio- och TV-sändningar, mobiltelefoni, trådlösa datornätverk, eller radar, så är antenner oumbärliga; de är nämligen länken mellan de elektromagnetiska vågorna oSum rules and physical limitations within electromagnetic theory and antenna theory have received significant attention in the last few years. However, the derivations are often relying on application specific and sometimes unsupported assumptions, and therefore a mathematically rigorous and generally applicable approach seems timely. Such an approach is presented in this thesis, along with exampl

Conflict Or Flexibility? Pharmaceutical Patents, Access to Medicines and the Role of Compulsory Licences

International law related to patents, on the one side, and human rights, on the other, both constitute interesting areas of law on their own. From time-to time the two distinct fields of international law intertwine. A tragic but highly relevant example is the ongoing HIV/AIDS epidemic. The core of law-related considerations of the HIV/AIDS epidemic consists of specific parts of the two fields, na

Tying as Abuse of Article 82 (d) of the EC Treaty - A Study of the Microsoft case

On 24 March 2004, the European Commission found Microsoft Corporation guilty of violating Article 82 of the EC Treaty. Consolidated version of the Treaty establishing the European Community, OJ C 325, 24.12.2002. The Commission established two separate violations of the provision. However, the relevant abuse in relation to this thesis was the finding of illegal tying by technical integration of Wi

Urban vindkraft - Dagens kunskapsläge

For a successful project of urban wind power requires wind as well as attachments, sound level and the requirements and regulations should be taken under consideration. But a lot of experience is still lacking and many projects fail therefore. This report covers the aspects described above and a summary of experiences and knowledge gaps have been made with the aim of facilitating the planning phas

Implementering Projekt Insikt

The government saw the negative effects of increased alcohol consumption in Sweden and Welfare gave the mandate to further develop an idea to counter the trend. The idea was presented and a decision was taken. When Ängelholms municipality was able to take advantage of opportunities on the basis of these decisions was launched Projekt Insikt. Decisions were taken on municipal management and the thr

Allocating IPR Generated in R&D Collaboration with Chinese Universities - A negotiation framework for managers

Issue of study: There is no clear framework for IPR negotiation to support the establishment of I-U collaboration by balancing their competing interests. For I-U collaborations within the same country, several sets of guidelines have been produced to emphasize IPR-issues in R&D collaborations. These have helped to increase awareness, but corporations and universities still report problems when

Patent Pools-An Effective Instrument for the High Technology Co-operation?

Companies share their intellectual property with potential competitors in many different ways, including patent pooling. A patent pool is an agreement between two or more patent owners to license one or more of their patents to one another or to third parties. In Europe the Commission used the term patent pool as the bringing together of the patents of two companies, which makes it available for u

THE LIMIT OF ARTICLE 28 EC - the ten year development of Keck and Mithouard

The Treaty provisions regulating the free movement of goods are articles 28 to 31 EEC (former articles 30 to 36). Article 28 prohibits Member States from discriminating, that is, favouring or in any other way putting its domestic products at an advantage against imported products unless the Member State can find just cause under article 30 (former article 36) for its practices. For a national meas

Prerequisites for learning from accident investigations - A cross-country comparison of national accident investigation boards

In this paper railway accident investigation reports issued by the national accident investigation boards in three Scandinavian countries during a 2-year period have been systematically studied. Content analysis of attributed causes in these reports reveals a considerable emphasis on physical processes, actor activities and equipment (the microlevel). Much less attention is paid to organisational

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Abstract in French Beaucoup d’hommes et de femmes aymara affirment que le savoir humain, transmis par la langue, n’est qu’un pur ‘siwsawi’, i.e. des paroles, des opinions, des points de vue, des jugements d’individus particuliers. Ainsi, il s’agit d’un savoir particulier ; c’est une connaissance concernant l’opinion de certaines personnes, rien de plus. Ceci est, de manière significative, différenMany Aymara men and women claim that human knowledge as transmitted through language is pure ‘siwsawi’, i.e. talk, opinions, views and judgments of particular individuals. As such it is knowledge of a particular kind; it is knowledge concerning the opinions of other humans, nothing else. It is thereby significantly different from the non-linguistic, experiential knowledge that is lived-through and

Belt-Shaped pi-Systems: Relating Geometry to Electronic Structure in a Six-Porphyrin Nanoring

Linear pi-conjugated oligomers have been widely investigated, but the behavior of the corresponding cyclic oligomers is poorly understood, despite the recent synthesis of pi-conjugated macrocycles such as [n]cycloparaphenylenes and cyclo[n]thiophenes. Here we present an efficient template-directed synthesis of a pi-conjugated butadiyne-linked cyclic porphyrin hexamer directly from the monomer. Sma