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Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas

Soft tissue and skeletal chondromas are rare entities, and only 21 cases with abnormal karyotypes have been reported. A survey of these, and 10 new cases reported herein, showed that the 12q13-15 segment is nonrandomly involved in structural rearrangements in chondromas. The HMGA2 (HMGI-C) locus in 12q15 is frequently rearranged in other benign mesenchymal tumors, and this study aimed at character

Cloning of four chitinase genes and a lectin gene in Galega orientalis

The legume goat's rue (Galega orientalis) and its microsymbiont Rhizobium galegae have an unusually strict host-bacteria specificity. The reason for this is not known. We have identified and analysed six genes in G. orientalis assumed to be involved in the recognition processes between legumes and rhizobia. The genes were isolated from a library made from nodulating roots. The genes were identifie

Attosecond Optical and Electronic Wave Packets

Popular Abstract in Swedish Vill man ta en bild av något som rör sig mycket snabbt, krävs det att man använder en kort exponeringstid. Om kamerans slutare är öppen under för lång tid, hinner det man vill fotografera röra sig under tiden filmen exponeras, med resultatet att bilden blir suddig. Kemiska reaktioner där atomer och molekyler är inblandade är exempel på något som sker på väldigt kort tidWhen a low-frequency laser pulse is focused to a high intensity in a gas, the electric field of the laser may become comparable to, or even exceed, the electric field between the electrons and the nucleus in the atom. Under such conditions, through a process known as high-order harmonic generation, bursts of extreme ultraviolet radiation may be emitted, with durations in the attosecond domain (1 a

Clinical and experimental studies on wear and osteolysis in total joint replacement

Popular Abstract in Swedish Total höftledsplastik är en vanlig och mycket framgångsrik behandling av smärttillstånd i höftleden. Enligt svenska höftplastikregistret opererades 12651 patienter år 2002 men 1056 patienter fick samma år genomgå ett utbyte av sin höftledsprotes (revision). Att höftleden vrids ur led (luxation) upprepade gånger eller infektion kan vara orsaken till revision men det vanlTotal hip arthroplasty is a very successful procedure. Despite this fact, however, a certain portion of patients has to be revised. One major reason for revision is the wear of the polyethylene leading to loosening and osteolysis. The overall aim of this thesis was to evaluate linear wear and migration of cemented, all - polyethylene sockets and polyethylene liners in total hip arthroplasty. The a

Downstream Processing Using Membrane Technology

Popular Abstract in Swedish Membranteknik är en separationsteknik där stora partiklar skiljs av från mindre partiklar m.h.a. ett membranfilter. I min forskning har jag tittat på hur membranfiltrering kan användas inom bioteknikindustrin. Jag har tittat på hur mjölksyra kan renas upp från en lösning av jäst "vetemjölsvälling" samt hur första steget i uppreningen av protein A från en industriellt prMembrane filtration is a very gentle separation technique and can be used at low temperatures. This makes it suitable for liquids that contain micro-organisms and/or are heat sensitive, which is often the case in liquids processed in the field of biotechnology. However, one drawback is that these liquids are often very complex, which is a disadvantage when using membrane technology as it makes the

Kvalet inför valet: Om elevers förväntningar och möten med vägledare i grundskolan

Popular Abstract in Swedish Med utgångspunkt i elevers väljande till gymnasieskolan har denna studie fokuserat på hur eleverna upplever detta val och med särskild betoning på samtalen mellan skolans syokon-sulenter (studie- och yrkesvägledare) och elever. Åtta elever har valts ut och samtliga deras samtal i årskurs nio med vägledare (4 stycken) har videoinspelats och analyserats. Dessutom har elevThe main purpose of this study is to highlight the counselling interview in connection with the choice of upper secondary school from three perspectives, the student's, the counsellor's and society's. The intention is to describe and analyse the counselling interview in the ninth grade with relation to: · the student's expectations, perceptions and values before and after the interviews, · the co

Studies on a serine peptidase inhibitor locus on human chromosome 20 Characterization of novel genes encoding proteins with WFDC and kunitz domains

An unlimited number of proteolytic reactions are carried out by enzymes in biological systems. These enzymes are a necessity of life, but they can also be dangerous if they are not controlled. Protease inhibitors regulate proteolytic enzymes by interacting and forming complexes with them, thereby preventing the substrate from gaining access to the active site of the enzyme. We have recently identi

Fusion of the FUS and ATF1 genes in a large, deep-seated angiomatoid fibrous histiocytoma

We report a case of a large, deep-seated, diagnostically difficult angiomatoid fibrous histiocytoma. The neoplastic cells were positive for vimentin, calponin, CD99, and, focally, for desmin and contained intertwining cytoplasmic processes joined by desmosomelike junctions. Fusion of codon 175 of the FUS gene to codon 110 of the ATF1 gene was detected by reverse transcription-polymerase chain reac

Carbohydrate recognition by enterohemorrhagic Escherichia coli: characterization of a novel glycosphingolipid from cat small intestine

A key virulence trait of pathogenic bacteria is the ability to bind to receptors on mucosal cells. Here the potential glycosphingolipid receptors of enterohemorrhagic Escherichia coli were examined by binding of S-35-labeled bacteria to glycosphingolipids on thin-layer chromatograms. Thereby a selective interaction with two nonacid glycosphingolipids of cat small intestinal epithelium was found. T