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Efficient Cluster-Based Catalysts for Asymmetric Hydrogenation of α-Unsaturated Carboxylic Acids.

The new clusters [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)], [H(4) Ru(4) (CO)(10) (1,1-P-P)] and [H(4) Ru(4) (CO)(11) (P-P)] (P-P=chiral diphosphine of the ferrocene-based Josiphos or Walphos ligand families) have been synthesised and characterised. The crystal and molecular structures of eleven clusters reveal that the coordination modes of the diphosphine in the [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)] clusters

Automated Decision Support for Bone Scintigraphy

A quantitative analysis of metastatic bone involvement can be an important prognostic indicator of survival or a tool in monitoring treatment response in patients with cancer The purpose of this study was to develop a completely automated decision support system for whole-body bone scans using image analysis and artificial neural networks. The study population consisted of 795 whole-body bone scan

Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers

Introduction Basal-phenotype or basal-like breast cancers are characterized by basal epithelium cytokeratin (CK5/14/17) expression, negative estrogen receptor ( ER) status and distinct gene expression signature. We studied the clinical and biological features of the basal-phenotype tumors determined by immunohistochemistry (IHC) and cDNA microarrays especially within the ER-negative subgroup. Meth

4MOST Survey Strategy Plan

The current status of and motivation for the 4MOST survey strategy, as developed by the Consortium science team, are presented here. Key elements of the strategy are described, such as sky coverage, number of visits and total exposure times in different parts of the sky, and how to deal with different observing conditions. The task of organising the strategy is not simple, with many different surv

The hot dayside and asymmetric transit of WASP-189 b seen by CHEOPS

The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can provide insights into the reflected light from exoplanets and constrain the short-wavelength thermal emission for the hottest of planets by observing oc

EDGE : the puzzling ellipticity of Eridanus II's star cluster and its implications for dark matter at the heart of an ultra-faint dwarf

The Eridanus II (EriII) 'ultra-faint' dwarf has a large (15 pc) and low-mass (4.3 × 103 M·) star cluster (SC) offset from its centre by 23 ± 3 pc in projection. Its size and offset are naturally explained if EriII has a central dark matter core, but such a core may be challenging to explain in a ΛCDM cosmology. In this paper, we revisit the survival and evolution of EriII's SC, focusing for the fi

The fate of planetesimals formed at planetary gap edges

The presence of rings and gaps in protoplanetary disks are often ascribed to planet-disk interactions, where dust and pebbles are trapped at the edges of planetary-induced gas gaps. Recent works have shown that these are likely sites for planetesimal formation via the streaming instability. Given the large amount of planetesimals that potentially form at gap edges, we address the question of their

EDGE : A new approach to suppressing numerical diffusion in adaptive mesh simulations of galaxy formation

We introduce a new method to mitigate numerical diffusion in adaptive mesh refinement (AMR) simulations of cosmological galaxy formation, and study its impact on a simulated dwarf galaxy as part of the 'EDGE' project. The target galaxy has a maximum circular velocity of 21 km s-1 but evolves in a region that is moving at up to 90 km s-1 relative to the hydrodynamic grid. In the absence of any miti

Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers

A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is compared to the identical selection from a noncancerous cell or a different type of cancer cell. The invention also includes a method of targeting at least one product of agene that includes administration

Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on th

Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on th

Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on th

Sets of probes and primers for the diagnosis of select cancers

A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is compared to the identical selection from a noncancerous cell or a different type of cancer cell. The invention also includes a method of targeting at least one product of a gene that includes administratio

Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on th