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Popular Abstract in English This work is focused on two accident types: accidents between motorized vehicles and pedestrians, and accidents between motorized vehicles and bicyclists. It aims at better understanding how the number of accidents is related to the number of road users; and how the speed at the site and age of the victim is related to how severe the injuries are. The work relies on sevThe aims of this work are to better understand (1) the relation between exposure and the risk of an accident between pedestrians and motorized vehicles and between bicyclists and motorized vehicles occurring at urban intersections and (2) how the speed environment and the victim´s age relate to the injury severity/outcome once a pedestrian or a bicyclist has been struck by a motorized vehicle. Cro

A software requirements specification (SRS) is an important document that reports the result from the system requirements determination (SRD) which forms a basis for subsequent activities in the systems development process. In order to increase the knowledge base of SRS and how they could be structured nine SRSs are analyzed. The analysis aims at demonstrate similarities and differences in SRS com

Popular Abstract in Swedish I takt med att resultaten för behandling av cancer hos barn och ungdomar blivit bättre, har kraven på en god livskvalitet efter avslutad behandling ökat. Man beräknar att år 2005 kommer 1/700 unga vuxna mellan 25-35 års ålder att vara långtidsöverlevande efter barncancer. Mer än 2/3 av dem som behandlats kommer att ha någon form av sena biverkningar, och hos hälften av Evaluation of long-term side effects of treatment is important due to the growing number of childhood cancer survivors. How kidney function is affected over time needs to be clarified. In the first article, we investigated 247 healthy infants and children and established upper reference limits for several proteins in urine, to be used as markers for glomerular and tubular proteinuria in children w

This thesis has focused on the development of methods and their applications for the identification of antibodies reactive with tumor associated antigens (TAA). The phage display technology provides a powerful mean to generate antibodies potentially useful for tumor immunotherapy. A phage antibody displays on its surface an antibody fragment encoded by a gene inserted in the phage genome. The phag

This PhD thesis consists of three separate papers. The common theme is methods to calculate analytical approximations for prices of different contingent claims under various model assumptions. The first two papers deals with approximations of standard European options in stochastic volatility models. The third paper is focused on approximating prices of commodity swaptions in a general model frame

We are surrounded by various chemicals, both naturally occurring and synthetically produced. Some, but not all, chemicals can be hazardous for human health following exposure, especially for vulnerable population groups including children, adolescents, and pregnant women. The increased use and production of chemicals have contributed positively to society in numerous ways, while also resulting in

Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci

Infectious and parasitic agents (IPAs) and their associated diseases are major environmental stressors that jeopardize bee health, both alone and in interaction with other stressors. Their impact on pollinator communities can be assessed by studying multiple sentinel bee species. Here, we analysed the field exposure of three sentinel managed bee species (Apis mellifera, Bombus terrestris and Osmia

Aims Social anxiety disorder (SAD) is one of the most common anxiety disorders and is associated with significant impairment and societal costs. The association between SAD and mortality remains poorly understood, partly because in epidemiological research it is rarely studied independently from other anxiety disorders. In this population-based matched cohort and sibling control study, we estimate

Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here we present Proteomics-based Artificial Intelligence for Dementia Diagnosis (ProtAIDe-Dx), a deep joint-learning model

Organizations’ external environment is full of business ventures. Individuals play ‘in role’ and ‘extra role’ at the same time within the organizations. They are also located in an online environment where they participate and communicate using online social tools. Moreover, individuals within organizations seldom know who are likely to provide the right information or knowledge. The "who kno

Target-controlled infusion (TCI) constitutes a clinically available alternative to manually administering the infusion rate of the anesthetic drug propofol. In TCI, a drug infusion profile is optimized to track a reference trajectory of blood plasma or effect site (brain cortex) drug concentration, or a corresponding clinical effect. TCI is a pure feed-forward openloop strategy, fully reliant on a

Background: Mental health problems among adolescents is a global challenge. During the transition to adolescence, physiological, psychological, and social changes occur, leading to increased vulnerability. Thus, adolescent boys are less likely to seek help for mental health problems, which makes them an undetected group. The aim of this study was to gain a deeper understanding of adolescent boys’

Imidacloprid is one of the most widely used soluble neonicotinoid insecticide, which is non–volatile and persists in the soil, with hazardous effects on birds, honeybees, and mammals. It is used in both agricultural and veterinary applications, and is found in at least 7% of European topsoils. One of the commercially available formulations is Confidor O–TEQ® that exhibits higher retention, spreadi

The vast clinical and radiological spectrum of pyruvate dehydrogenase complex (PDHc) deficiency continues to pose challenges both in diagnostics and disease monitoring. Prompt diagnosis is important to enable early initiation of ketogenic diet. The patients were recruited from an ongoing population-based study in Sweden. All patients with a genetically confirmed diagnosis who had been investigated

In 2015, the Zambian government and the Swedish International Development Cooperation Agency (Sida) signed an agreement in which Sida committed to funding a program for Reproductive, Maternal, Newborn, Child, Adolescent Health and Nutrition (RMNCAH). The program includes a results-based financing (RBF) model that aims to reward Zambian districts for improved district-wide results on relevant indic

Background. Pervasive refusal syndrome (PRS) is a severe child psychiatric syndrome not yet included in the international classification and mostly affecting girls aged 7-15 years. Hospital admission and severe loss of function extend for many months and years but most recover. Autism has been suggested as a predisposing factor but largely lacks support for typical cases of PRS. Treatment is not e

The Sardinian dhole (Cynotherium sardous) was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene. Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African hunting doThe Sardinian dhole (Cynotherium sardous)1 was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene.2-5 Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African huntin

AimOur aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.MethodsThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are

While the clinical importance of CD8+ and CD3+ cells in colorectal cancer (CRC) is well established, the impact of other immune cell subsets is less well described. We sought to provide a detailed overview of the immune landscape of CRC in the largest study to date in terms of patient numbers and in situ analyzed immune cell types. Tissue microarrays from 536 patients were stained using multiplexe