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© 2017 Metal cutting simulations have become an important part of cutting tool design and the research in the field in general. One of the most important aspects of modeling is the accuracy of the tool geometry. 3D microscopy is used for measuring the tool edge radius with good accuracy. However, especially with sharp tools, i.e. small tool edge radii, the measurements, no matter how accurate, are
The compressibility of a protein relates to its stability, flexibility, and hydrophobic interactions, but the measurement, interpretation, and computation of this important thermodynamic parameter present technical and conceptual challenges. Here, we present a theoretical analysis of protein compressibility and apply it to molecular dynamics simulations of four globular proteins. Using additively
Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and platelet-derived growth factor (PDGF) exert trophic effects on striatal neurons in vitro, which raises the possibility that these growth factors might also counteract neuronal death provoked by various insults. We have found that BDNF and NT-3, but neither PDGF-AA nor -BB, added 24 h before the insult ameliorated hypoglycemic neu
Thin organic coatings (TOC) or paints on hot dip galvanized steel (HDGS) improve the corrosion properties and create visually pleasing surfaces. Delamination of these coatings leads to corrosion and peeling of the paints. Hence, a novel method for improved adhesion and corrosion properties for HDGS surfaces is introduced. It is shown how the fabrication of a nanomolecular silane film as an interfa
Background: Cadmium bioaccumulates in the body and causes several adverse health effects. Understanding the primary sources of exposure is critical in order to implement effective prevention measures. Methods: We included 454 adults enrolled in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) during 1992–98. At enrolment, information was collected on d
Hydrogen is an element of fundamental importance for energy but hard to quantify in bulk materials. Neutron radiography was used to map . in situ loss of elemental hydrogen from beech tree wood samples during pyrolysis. The samples consisted of three wood cylinders (finished dowel or cut branch) of approximately 1 cm in length. The samples were pyrolyzed under vacuum in a furnace vessel that was p
We report measurements of the production of prompt D0, D+, D*+ and Ds + mesons in Pb–Pb collisions at the centre-of-mass energy per nucleon-nucleon pair sNN=5.02 TeV, in the centrality classes 0–10%, 30–50% and 60–80%. The D-meson production yields are measured at mid-rapidity (|y| < 0.5) as a function of transverse momentum (pT). The pT intervals covered in central collisions are: 1 < pT< 50 GeV/
We have tried to calculate the free energy for the binding of six small ligands to two variants of the octa-acid deep cavitand host in the SAMPL5 blind challenge. We employed structures minimised with dispersion-corrected density-functional theory with small basis sets and energies were calculated using large basis sets. Solvation energies were calculated with continuum methods and thermostatistic
Movement quality assessed by the Body Awareness Rating Scale (BARS) is used as an indicator of health and self-efficacy in patients with long-lasting musculoskeletal and mental health problems. The objective of the study was to examine reliability and construct validity of the movement quality scale. 25 patients and 25 healthy persons were included. Internal consistency was examined by Cronbach's
In recent decades, obesity has gone from being a problem of first world countries to a global one. It is considered one of the main risk factors for many serious medical conditions. In order to treat and/or prevent obesity different strategies have been considered, one of the most common being the inhibition of lipase, the enzyme that is mainly responsible for lipid digesti
Mechanical stimuli, such as wind, rain, and touch affect plant development, growth, pest resistance, and ultimately reproductive success. Using water spray to simulate rain, we demonstrate that jasmonic acid (JA) signaling plays a key role in early gene-expression changes, well before it leads to developmental changes in flowering and plant architecture. The JA-activated transcription factors MYC2
Exceptionally preserved Mesozoic feathered dinosaur fossils (including birds) are famous, but recognized from only very few localities worldwide, and are especially rare in the Southern Hemisphere. Here we report an assemblage of non-avian and avian dinosaur feathers from an Early Cretaceous polar (around 70°S) environment in what is now southeastern Australia. The recovered remains incorporate sm
The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C gene in Saccharomyces cerevisiae shows high sequence similarity to METTL21A and VCP-KMT, as well as to their uncharacterized paralogues METTL21B and METTL21C. Despite being most
Background: Whole-cell biocatalysis based on metabolically active baker's yeast with engineered transamination activity can be used to generate molecules carrying a chiral amine moiety. A prerequisite is though to express efficient ω-transaminases and to reach sufficient intracellular precursor levels. Results: Herein, the efficiency of three different ω-transaminases originating from Capsicum chi
Purpose - To offer knowledge about the global development of largescale demand responsive transport systems (DRT), and to stimulate dialogue and collaboration for further innovation and improvement of these systems. Design/methodology/approach - A review of the literature shows how DRT has evolved from the first applications in the 1970s to very complex operations in the last two decades with hund
It has been shown that vegetation growth in semi-arid regions is important to the global terrestrial CO2 sink, which indicates the strong need for improved understanding and spatially explicit estimates of CO2 uptake (gross primary production; GPP) in semi-arid ecosystems. This study has three aims: (1) to evaluate the MOD17A2H GPP (collection 6) product against GPP based on eddy covariance (EC) f
Empirically, this thesis has focused on nine research and development (R&D) networks set up to promote a professional approach to care and strengthen the collaboration between health care sectors in a Swedish health care setting. The research project was embedded in an action research approach intended to encourage network development by means of a dialogical process. The specific research que
