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Background: Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been shown to affect the epigenome in whole blood, pancreatic islets, and adipose tissue in humans, and genome-wide DNA methylation studies have linked epigenetic ch
Artificial intelligence (AI) has shown promising results in digestive endoscopy, especially in capsule endoscopy (CE). However, some physicians still have some difficulties and fear the advent of this technology. We aimed to evaluate the perceptions and current sentiments toward the use of AI in CE. An online survey questionnaire was sent to an audience of gastroenterologists. In addition, several
Kidney Exchange Programs (KEP) are valuable tools to increase the options of living donor kidney transplantation for patients with end-stage kidney disease with an immunologically incompatible live donor. Maximising the benefits of a KEP requires an information system to manage data and to optimise transplants. The data input specifications of the systems that relate to key information on blood gr
Culture and creativity are often described as central elements in urban and regional development. This paper takes its point of departure in an ongoing research project on the work of professionals at platforms for creative and cultural work in Scania, Sweden. Through narratives of and about the professionals at the different platforms the paper illustrates how creativity and creative work are enc
Hippocampal atrophy is endemic in ‘normal aging’ but it is unclear what factors drive age-related changes in medial temporal lobe (MTL) structural measures. We investigated cross-sectional (n = 191) and longitudinal (n = 164) MTL atrophy patterns in cognitively normal older adults from ADNI-GO/2 with no to low cerebral β-amyloid and assessed whether white matter hyperintensities (WMHs) and cerebro
Studien berör användningen av sociala kategorier i polisiär och statlig verksamhet, och visar att social kategorisering leder till en rad problematiska konsekvenser. Efter uppmärksammandet av polisens så kallade Romregister uppstod en debatt om polisens arbetsmetoder och huruvida fördomar förekom inom den polisiära organisationen. Polisiära och statliga insatser som riktar sig mot en särskild grupThis thesis discusses the use of stereotypes and social categories in the police force. The study illustrates how stereotypes inevitably lead to several problematic consequences. Following the uncovering of the so called ”Romani-register”, a debate occurred whether stereotypes existed in the Swedish police force. Targeted police efforts and government initiatives are however a consequence of the c
In last decade, the lighting industry significantly changed with the development of light emitting diodes (LEDs) and their corresponding penetration of the market. The new technology increases energy efficiency and longevity compared to other types of lamps. As a result, LEDs can improve the sustainability performance of cities and towns, contributing to the mitigation of climate change and cuttin
Mn5Ge3(001) thin films grown on Ge(111) were studied by angle-and spin-resolved photoemission using synchrotron radiation in the 17-40 eV photon energy range. The photoelectron spectra were simulated starting from a first-principles band-structure calculation for the ground state, using the free-electron approximation for the final states, taking into account photohole lifetime effects and k(perpe
Objective: The aim of this study was the validation of the criteria defining a significant mucocutaneous-bleeding history in type 1 von Willebrand disease (VWD). Subjects and methods: To avoid selection bias, 42 obligatory carriers (OC) of type 1 VWD were identified from a panel of 42 families with type 1 VWD enrolled by 10 expert centers. OC were identified by the presence of an offspring and ano
Popular Abstract in Swedish Blodförgiftningen (sepsis) kan ge upphov till akut hjärtsvikt, vilken på cellulär nivå karakteriseras av minskad känslighet för kalciumjonen och de vanliga hjärtförstärkande medicinerna (inotropa farmaka). Avhandlingen handlar om tidig behandling av sepsis-associerad hjärtsvikt med den kalciumsensitiseraren levosimendan, ett nytt läkemedel som höjer hjärtats kontraktionSepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. We investigated the effects of clinically relevant plasma concentrations of the calcium sensitizer levosimendan during the first 6 h of endotoxemia in a model of
Land cover and land management changes (LCLMCs) have a substantial impact on the global carbon budget and, consequently, on global climate via the biogeochemical (BGC) effects. The commonly considered BGC effects refer to the direct influence of LCLMCs on local carbon stocks (local BGC effects). However, LCLMCs also influence climate by altering the local surface energy balance due to changes in l
Long-term noninvasive respiratory support, comprising continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV), in children is expanding worldwide, with increasing complexities of children being considered for this type of ventilator support and expanding indications such as palliative care. There have been improvements in equipment and interfaces. Despite growing experience, t
Arbetet behandlar uppsåtsbegreppet i svensk och dansk rätt. Arbetet fokuserar särskilt på den nedre gränsen för uppsåt i svensk och dansk rätt. Uppsåt kan sägas innebära att någon gör en kriminaliserad gärning med vett och vilja. Domstolar, juridiska praktiker och teoretiker behöver dock ha ett mer preciserat uppsåtsbegrepp. I svensk rätt skiljer man på direkt, indirekt och eventuellt uppsåt, där
Popular Abstract in Swedish Syftet med den här studien är att undersöka utvecklingen av språkfärdigheten i skriftlig produktion av franska som främmande språk. Vi har följt 5 inlärares produktion av franska i en 30 månader lång longitudinell studie. För att kunna utvärdera färdigheten har vi använt oss av parametrarna flyt, komplexitet och korrekthet. Flyt och komplexitet har utvärderats med hjälpThe aim of this study is to examine the development of linguistic proficiency in written production of second-language French. In a longitudinal study of 30 months, we follow the written production of 5 guided learners of French as a second language. In order to apprehend proficiency we use the conventional parameters fluency, complexity and accuracy. The fluency and complexity are apprehended by
SAMHD1 degrades deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA. Davenne et al. find that SAMHD1 protects cells against dNTP imbalances. Exposure of SAMHD1-deficient cells to deoxyguanosine (dG) results in increased intracellular dGTP levels and subsequent apoptosis. This can be exploited to selectively kill cancer cells that acquired SAMHD1 mutations.
Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the only known high-affinity copper importer in the brain, decreases in the substantia nigra of Parkinson's disease patients. However, the relationship between copper, copper transporte
Purpose: Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the poor prognosis of high-grade glioma patients, and is known to contribute to the development of treatment resistance. Therefore, new strategies to comprehensively profile and monitor the hypoxic status of gliomas are of high clinical relevanc
HIGHLIGHTS • The Anthropocene compels unlocking of ocean-related network capabilities. • Orchestration of local, regional, and global knowledge networks can augment transformative capacity. • Transdisciplinary network diagnostics are promising social learning tools. • Strategic advice for transformational research in ocean territories are provided. This paper dedicates to understanding of what is
Background: Non-alcoholic fatty liver disease has been associated with increased mRNA expression of FADS2 in the liver and estimated activity of delta-6 desaturase in serum, encoded by the FADS2 gene. Since DNA methylation in the FADS1/2/3 gene cluster has been previously linked with genetic variants and desaturase activities, we now aimed to discover factors regulating DNA methylation of the CpG
