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The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production in cells for bioprocessing have failed as lactate

Flight behaviours of birds have been extensively studied from different angles such as their kinematics, aerodynamics and, more generally, their migration patterns. Nevertheless, much is still unknown about the daily foraging flight activity and behaviour of breeding birds, and potential differences among males and females. The recent development of miniaturized accelerometers allows us a glimpse

INTRODUCTION: Inhibitor development against factor VIII (FVIII) is the most common complication of hemophilia A replacement therapy. One of the variables considered to influence inhibitor development is the ABO blood group. Patients with blood group O have, on average, a 30%-40% lower endogenous von Willebrand factor (VWF) concentration. It has been postulated that VWF levels influence inhibitor d

Årets upplaga av Gamla Lunds årsbok tar oss med på en fascinerande resa längs en av stadens äldsta och mest betydelsefulla gator – Klostergatan. Genom århundradena har gatan spelat många roller: från kyrkligt och kungligt maktcentrum under medeltiden, till en livlig social arena för studenter och borgerskap på 1800- och 1900-talen, och däremellan en plats för fattighus, handlande och hantverkare.B

In this study, a literature review was conducted to identify indicators that can be utilised to assess and visualise the potential of the geophysical environment to deliver geosystem services. The literature review identified 24 studies and 22 technical reports, resulting in a list of 75 geosystem services indicators for 23 geosystem services associated with the subsurface. Building upon these fin

Osteoarthritis (OA) is a highly prevalent joint disease, affecting millions of people worldwide and characterized by degradation of articular cartilage, subchondral bone remodeling and low-grade inflammation, leading to pain, stiffness and disability. Cartilage Oligomeric Matrix Protein (COMP) is a major structural component of cartilage and its degradation has been proposed as a marker of OA seve

Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that RORγt+ DCs are a co

Background: Several cancer types have increased PFKFB3, a glycolytic enzyme for which potent inhibitors have been found. Inhibition of PFKFB3 impairs DNA repair after irradiation of cancer cells, making it a possible radiosensitization target. The SweBCG91RT trial, in which breast cancer patients were randomized to postoperative radiotherapy or not, was used to investigate PFKFB3 as a clinical mar

This paper describes a general picture of efforts to provide women with equal opportunity both on a national political level, and within academia. A report of recent activities within the newly formed National Division for Women in Physics within the Swedish Physical Society is also given

We present a review of some of the current major challenges in stellar cluster research, including young clusters, globular clusters, and galactic nuclei. Topics considered include: primordial mass segregation and runaway mergers, expulsion of gas from clusters, the production of stellar exotica seen in some clusters (e.g., blue stragglers and extreme horizontal-branch stars), binary populations w

Little is known about cross-language measurement equivalence of the job content questionnaire (JCQ) The purposes of this study were to assess the extent of cross-language differential item functioning (DIF) of the 27 JCQ items in six languages (French, Dutch, Belgian-French, Belgian-Dutch (Flemish), Italian, and Swedish) from six European research centers and to test whether its effects on the sca

To conduct a survey across European cardiac centres to evaluate the methods used for cerebral protection during aortic surgery involving the aortic arch.

SAYP 2021, Lund University: Perspectives on Multi-level Government, Decentralisation and Human Rights SAYP 2021, Lund University: Perspectives on Multi-level Government, Decentralisation and Human Rights SAYP is a training programme financed and initi­ ated by the Swedish Institute and is developed to build new networks, knowledge and practices for increased transparency, efficiency and resilience

https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2021-02/SAYP%202021%20Decentralisation%20and%20Human%20Rights.pdf - 2026-05-28

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that has been shown to be associated with allergic comorbidities. However, studies examining comorbidities in patients with AD are incomplete, which may contribute to suboptimal care. Objectives: The objective was to compare the risk of developing different allergic and nonallergic comorbidities among adult patients with AD

Background: Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we aimed to investigate clinical outcomes up to 9 years after amyloid-PET to support the clinical validity of the imaging technique. Methods: We analyzed longitud

Background: Brain CT can be used to evaluate pediatric patients with suspicion of cerebral pathology when anesthetic and MRI resources are scarce. This study aimed to assess if pediatric patients referred for an elective brain CT could endure a diagnostic fast brain MRI without general anesthesia using a one-minute multi-contrast EPI-based sequence (EPIMix) with comparable diagnostic performance.

Perceptual centers (p-centers) can be defined as the perceived centers of a syllable. Previous research regarding the location of p-centers in speech relied on experimental methods, and among the suggested acoustic features contributing to the location of p-centers in Germanic languages is the transition of the consonant to the vowel onset. The current study investigates the prediction of the loca

The binocular field of vision differs widely in birds depending on ecological traits such as foraging. Owls (Strigiformes) have been considered to have a unique binocular field, but whether it is related to foraging has remained unknown. While taking into account allometry and phylogeny, we hypothesized that both daily activity cycle and diet determine the size and shape of the binocular field in

AIM: The study aimed to assess the haemodynamic effects of fludrocortisone and midodrine, alone or combined, in patients with recurrent syncope and/or symptoms due to hypotension and ≥ 1 daytime systolic blood pressure (SBP) drop < 90 mmHg or ≥ 2 daytime SBP drops < 100 mmHg recorded by 24-h ambulatory blood pressure monitoring (ABPM1).METHOD: A total of 53 patients (mean age, 40.9 ± 18.5 years, 3