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Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the fact

Vehicular networks allow for a variety of applications ranging from platooning to fully automated driving. Most of such applications require the vehicles that constitute the networks to be aware of their relative or absolute position as well as the position of nearby vehicles. To this end, multiple positioning methods can be employed, among such methods are Global Positioning Systems or methods th

Urbana översvämningar orsakar stora samhällsskador och skyfallens snabba och lokala karaktär gör dem svåra att observera, förutsäga och varna för. Det finns också brist på data om översvämningsskador, främst på grund av knapp och icke-systematisk datainsamling och -hantering. I denna artikel presenterar vi ett nytt forskningsprojekt: SPARC. Det övergripande syftet med projektet är att förbättra säUrban flooding causes large societal damages and increased climate adaptation measures is needed. Therapid and local character of extreme rain events make them difficult to observe and predict, and to issuewarnings for. There is also a lack of data on urban flood damages, mainly because of scarce and nonsystematic data collection and management. In this paper, we present the approaches behind the

OBJECTIVE: Genome-wide association studies have begun to elucidate the genetic architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms (SNPs) identified through targeted complementary approaches affect diabetes incidence in the at-risk population of the Diabetes Prevention Program (DPP) and whether they influence a response to preventive interventions. RESEARCH DESIGN

The problem of continuous-time process parameter identification is considered. Filtered input-output process signals are used to create a linear differential equation governed by the same continuous-time process parameters. The estimation scheme is implemented by sampling the filtered signals and using a recursive least squares algorithm (RLS). The choice of filter leads to different parameter con

Sustainable agriculture requires nutrient management options that lead to a profitable crop yield with relatively low nitrogen (N) losses to the environment. We studied whether the addition of contrasting organic amendments together with inorganic fertilizer can promote both requirements simultaneously. In particular we studied how the chemical composition of organic amendments affects the biomass

Background: The production of ethanol and other fuels and chemicals from lignocellulosic materials is dependent of efficient xylose conversion. Xylose fermentation capacity in yeasts is usually linked to xylose reductase (XR) accepting NADH as cofactor. The XR from Scheffersomyces stipitis, which is able to use NADH as cofactor but still prefers NADPH, has been used to generate recombinant xylose-

The urokinase-type plasminogen activator receptor (uPAR) is a non-integrin vitronectin (VN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor. Through structure-function analyses of uPAR, VN and integrins, we document that uPAR-mediated cell adhesion to VN triggers a novel type of integrin signalling that is independent of integrin-matrix engagement. The signalling is ful

MicroRNAs are able to modulate gene expression in a range of diseases. We focused on microRNAs as potential contributors to the pathogenesis of ascending aorta (AA) dilatation in patients with stenotic tricuspid (TAV) or bicuspid aortic valve (BAV). Aortic specimens were collected from the ‘concavity’ and the ‘convexity’ of mildly dilated AAs and of normal AAs from heart transplant donors. Aortic

Integrated development environments (IDEs) increase programmer productivity, providing rapid, interactive feedback based on the syntax and semantics of a language. A heavy burden lies on developers of new languages to provide adequate IDE support. Code generation techniques provide a viable, efficient approach to semi-automatically produce IDE plugins. Key components for the realization of plugins

Purpose: The excess cardiovascular morbidity associated with schizophrenia is attributed to an interplay between behavioural (physical inactivity, unhealthy diet, substance abuse), genetic and illness related factors, as well as the effects of antipsychotic treatment. Patients have limited access to physical healthcare with less opportunity for cardiovascular risk prevention and treatment programm

Nutrigenetics considers the influence of individual genetic variation on differences in response to dietary components, nutrient requirements and predisposition to disease. Nutrigenomics involves the study of interactions between the genome and diet, including how nutrients affect the transcription and translation process plus subsequent proteomic and metabolomic changes, and also differences in r

The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-basedrecommendations on the management of patients with intracranial atherosclerotic disease (ICAD). The guidelines wereprepared following the Standard Operational Procedure of the European Stroke Organisation guidelines and accordingto GRADE methodology. ICAD represents a major cause of ischemic

Renal cell carcinoma (RCC) is a tumour type with an indolent growth pattern and rather vague symptoms. The present study developed a platform for liquid biopsy of RCC based upon the isolation of circulating tumour cells (CTCs). Founded on the observation that RCC tumour cells are considerably larger than leucocytes, the present study employed a microfluidics-based system for isolation of RCC CTCs

Kursplan SKÅF02 Skådespeleriets grunder - fortsättning STYR 2023/2595 Konstnärliga fakulteten SKÅF02, Skådespeleriets grunder - fortsättning, 30 högskolepoäng The Fundamentals of Acting - Continuation, 30 credits Grundnivå / First Cycle Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2023-11- 29 (STYR 2023/2595). Kursplanen träder i kraft 2023-11-30 och

https://www.thm.lu.se/sites/thm.lu.se/files/2023-12/Sk%C3%A5despeleriets%20grunder%20-%20forts%C3%A4ttning.pdf - 2026-05-26

Library 2.0 Introduction to VuFind Demian Katz Director of Library Technology, Falvey Memorial Library, Villanova University demian.katz@villanova.edu Overview • What is VuFind? – What problems does it solve? – What are its key features? – What systems can it interact with? • How does VuFind interact with EBSCO products? • How can I implement VuFind? • Where can I learn more about VuFind? • What i

https://www.ub.lu.se/sites/ub.lu.se/files/2022-05/VuFind%20som%20open%20source-discovery,%20samt%20som%20open%20source-opac%20f%C3%B6r%20FOLIO_Demian%20Katz.pdf - 2026-05-26

We describe an experimental setup for non-linear interaction and propagation of ultrashort and intense x-ray free-electron laser (XFEL) pulses in a dense gas. It allows one to provide high, but adjustable, target-gas pressures of up to 6 bar within a vacuum environment of 3∙10− 3 mbar or better. The setup enables investigation of intense x-ray propagation in an optically thick medium with minimal

Urban climate resilience planning often overlooks the subsurface, despite its potential to mitigate flooding, heat stress, and drought. To demonstrate these potentials, we developed thematic Geosystem Service (GS) maps for Malmö, Sweden, to support the integration of the subsurface into climate adaptation strategies. This study identifies GS relevant to the local context, proposes indicators for m

Understanding the genetic regulation of blood CD34+ cell levels could lead to better methods for stem cell mobilization and transplantation. Recently, in a genome-wide association study (GWAS), we identified 11 genetic associations with blood CD34+ cell levels. One of the most significant maps to an intergenic region between the ENO1 and RERE genes at chromosome 1p36.23. However, the underlying me