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Soluble inflammatory markers obtained from non-invasive airway sampling such as induced sputum may be useful biomarkers for targeted pharmaceutical interventions. However, before these soluble markers can be used as potential targets, their variability and reproducibility need to be established in distinct study populations.
We consider the problem of approximating functions that arise in wave-equation imaging by sums of wave packets. Our objective is to find sparse decompositions of image functions, over a finite range of scales. We also address the naturally connected task of numerically approximating the wavefront set. We present an approximation where we use the dyadic parabolic decomposition, but the approach is
Popular Abstract in Swedish Syftet med denna undersökning är att diskutera inlärares signaler om hjälp att uttrycka sig på främmande språk, här franska, signaler som här kallas ?sollicitationer?. Undersökningen handlar om vilken roll dessa spelar för den fortsatta utvecklingen av samtalet med den infödde talaren, närmare bestämt för att utlösa s.k. SPA (Séquences Potentiellement Acquisitionnelles)The aim of this study is to discuss how ?soliciting? (non-native speakers? requests of native speakers for help in how to express themselves in a foreign language) may play a part in the triggering of SPAs (Séquences Potentiellement Acquisitionnelles or ?learning?teaching sequences?). The beneficial effect of SPAs for learning is still controversial, since no correlation has yet been shown between
This paper deals with optimal load balancing in telecommunication networks based on multiple spanning tree routing. This is the case in switched Ethernet networks where the operator configures different routing spanning trees and assigns each demand VLAN to one of the spanning trees. We consider modeling and solving three load balancing objectives: (i) minimization of the average link load with a
In order to identify the protein responsible for a dopamine peroxidizing activity, previously described in human normal and parkinsonian substantia nigra by our group, we developed non-denaturing polyacrylamide gel electrophoresis conditions, mimicking the characteristic colour in vitro reaction, resulting from cyclic oxidation of dopamine (DA). After separating protein mixtures from human normal
A novel immunoassay (PINC-ELISA) was designed using proteinase inhibitors of the cystatin superfamily (PINC) in the solid phase, to promote the selective capture of cysteine proteinases. The method was applied in the identification of papain-like antigens from parasitic protozoa. PINC of human origin, namely recombinant cystatin C (r-cystatin C) or low molecular weight kininogen were used in the a
Recent developments of surrogate assays for human hematopoietic stem cells (HSC) have facilitated efforts at improving HSC gene transfer efficiency. Through the use of xenograft transplantation models, such as nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice, successful oncoretroviral gene transfer to transplantable hematopoietic cells has been achieved. However, because of the l
The Sagittarius dwarf spheroidal galaxy is in an advanced stage of disruption but still hosts its nuclear star cluster (NSC), M54, at its center. In this paper, we present a detailed kinematic characterization of the three stellar populations present in M54: Young metal-rich (YMR); intermediate-age metal-rich (IMR); and old metal-poor (OMP), based on the spectra of 6500 individual M54 member stars
Theory predicts that we should find fast, ejected (runaway) stars of all masses around dense, young star-forming regions. N-body simulations show that the number and distribution of these ejected stars could be used to constrain the initial spatial and kinematic substructure of the regions. We search for runaway and slower walkaway stars within 100 pc of the Orion Nebula Cluster (ONC) using Gaia D
In this work, atmospheric pollutant emissions of NOx, SOx, CO, particulate matter (PM), total organic compounds (TOC), and CO2 from larger stationary sources of pollutants in Brazil were inventoried and spatialized over the whole Brazilian territory for the base year 2011. The developed inventory comprises a total of 16 refining units, 1730 thermoelectric power plants (TPPs), 96 cement industries,
Changes in the inlet morphology of choked coastal lagoons often restrict the water exchange with the sea, making them vulnerable to pollution events and eutrophication processes. In this study, the importance of tides for the water exchange was investigated in Mundaú Lagoon, which is a choked lagoon located in northeastern Brazil that has a very dynamic inlet and channel system. The analysis was c
Whole exome sequence analysis was performed in a Swedish mother-father-affected proband trio with a phenotype characterized by progressive retinal degeneration with congenital nystagmus, profound congenital hearing impairment, primary amenorrhea, agenesis of the corpus callosum, and liver disease. A homozygous variant c.806T > C, p.(F269S) in the tyrosyl-tRNA synthetase gene (YARS) was the only id
Objectives: North Sea–Progressive Myoclonus Epilepsy (NS-PME) is a rare, childhood-onset disorder primarily characterized by movement disorders including progressive myoclonus and ataxia; subsequently accompanied by varying degrees of epilepsy. While motor symptoms are clearly defined, quality of life (QoL) has never been investigated in NS-PME. Additionally, nonmotor symptoms (NMS) including anxi
BACKGROUND: Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP.OBJECTIVE: This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persiste
X-ray Fluorescence microscopy is a sophisticated advanced technique which can provide information regarding the concentration and the distribution of chemical elements within biological samples. It is increasingly used in the study of cells and tissues as it does not require the use of staining or fluorescent probes. For XRF measurements, sample preparation is a key step in the analytical process
Denna uppsats behandlar ämnet religionsutövning i svenskt arbetsliv. Ämnet avhandlas dels utifrån perspektivet religionsfrihet som mänsklig rättighet, dels från perspektivet skydd och aktiva åtgärder mot diskriminering med religion som grund. Syftet är att göra en utredning i ämnet samt belysa frågan. Religionsfriheten stadgas i artikel 9 i Europakonventionen om de mänskliga rättigheterna och grun
When primary tumor cells are grown in vitro, they are exposed to an environment that is vastly different from the tumor environment they originate from. The in vitro environment can lack the three-dimensional structure of the tumor, other cell types present within the tumor microenvironment, and important growth factors. Humanized mouse models allow researchers to study primary tumor cells in a mo
Asparaginase is a mainstay of treatment of childhood acute lymphoblastic leukemia. Pegylation of asparaginase extends its biological half-life and has been introduced in the newest treatment protocols aiming to further increase treatment success. Hyperammonemia is a recognized side effect of asparaginase treatment, but little is known about its incidence and clinical relevance. Alerted by a patien
