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Man against machine : diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists

Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l

Conifer-killing bark beetles locate fungal symbionts by detecting volatile fungal metabolites of host tree resin monoterpenes

Outbreaks of the Eurasian spruce bark beetle (Ips typographus) have decimated millions of hectares of conifer forests in Europe in recent years. The ability of these 4.0 to 5.5 mm long insects to kill mature trees over a short period has been sometimes ascribed to two main factors: (1) mass attacks on the host tree to overcome tree defenses and (2) the presence of fungal symbionts that support suc

FMT-metoden - En studie om hur verksamma terapeuter talar om sin metod och sitt arbetssätt

Title: A study of how active therapist talks about the FMT method. FMT-therapists use music as a means of communication. The method is non verbal and uses musical codes to create a framework for the apprentice. The instruments that are being used are piano, drums, a variety of flutes and whistles. The FMT-method is a musical form of therapy that targets all functional disabilities. It is a neuromu

Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic

Skapandet av en föreställd gemenskap - det "nya Europa"

Den här uppsatsen skall undersöka några av företeelserna som har betydelse för ett skapande av en europeisk identitet och ett "gemensamt" Europa. Diskussionen om Europa som gemensam institution handlar oftast om ekonomiska svårigheter, sällan diskuteras t.ex. historiska, normativa, och kulturella mellanmänskliga och mellanstatliga dilemman i större sammanhang. Frågan jag ställer i uppsatsen tar ju

Organiserande av stöd och service till barn med funktionshinder : Om projektnät, språkliga förpackningar och institutionella paradoxer

Popular Abstract in Swedish Avhandlingen är en studie av hur stöd och service organiseras kring fyra barn med funktionshinder och deras familjer. I denna service är normalt flera olika formella organisationer involverade, som barnhabilitering, förskola/skola/särskola, hjälpmedelscentral, assistentorganisationer, sjukvård m fl. Dessutom kan barnets och familjens situation vara komplicerad på många This study explores the organising of services for disabled children and their families in Sweden. It is based on 83 interviews with parents and involved staff surrounding four disabled children, with both physical and intellectual disabilities, and between two and nine years old. Further, 15 meetings between parents and staff were observed, primarily serving as background material. The service pr

Inner ear is a target for insulin signaling and insulin resistance : evidence from mice and auditory HEI-OC1 cells

OBJECTIVE: The mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to investigate whether the organ of Corti could be a target tissue for insulin signaling using auditory House Ear Institute-Organ of Corti 1 (HEI-OC1) cells

Dose escalation of chart in non-small cell lung cancer: is three-dimensional conformal radiation therapy really necessary?

PURPOSE: To evaluate, preclinically, the potential for dose escalation of continuous, hyperfractionated, accelerated radiation therapy (CHART) for non small-cell lung cancer (NSCLC), we examined the strategy of omission of elective nodal irradiation with and without the application of three-dimensional conformal radiation technology (3DCRT). METHODS AND MATERIALS: 2D, conventional therapy plans we

Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo

Background. During early mouse development, two extra-embryonic lineages form alongside the future embryo: the trophectoderm (TE) and the primitive endoderm (PrE). Epigenetic changes known to take place during these early stages include changes in DNA methylation and modified histones, as well as dynamic changes in gene expression. Results. In order to understand the role and extent of chromatin-b

Commodity Currencies vs Fiat Money - Automaticity vs Embedment

Commodity currencies have been stood against fiat money in the discourses on the history of money, implying a development from primitive forms of money – which needed anchor in a real commodity to gain acceptance, for instance gold, silver or copper – to a more sophisticated monetary regime based solely on confidence and trust. This paper argues that the idea of a gradual replacement of the former

Technoscience comes to Lund : ESS and the Enlightenment Vision

In 2019 the first neutrons will be fired at the ESS plant, at least to its present plan, located in the outskirts of Lund, the brightest neutron facility in the world. In the scientists’ self-images, this kind of high technology and international cooperative knowledge production is entitled Big Science or Global Science. The concept “technoscience” isn’t used. This chapter will discuss if the conc

Permanent pacemaker implantation early and late after heart transplantation : clinical indication, risk factors and prognostic implications

BACKGROUND: Permanent pacemaker implantation (PPM) early after cardiac transplantation has been shown not to predict a worse outcome. However, the requirement for pacing late after transplantation and its prognostic implications are not fully known. We describe the clinical indications, risk factors and long-term outcome in patients who required pacing early and late after transplantation.METHODS:

Utvärdering av dubbdäcksförbudets effekt på luftkvaliteten på Friggagatan

I syfte att utvärdera effekten av dubbdäcksförbudet på Friggagatan med avseende på luftkvaliteten har Miljöförvaltningen i Göteborg på uppdrag av trafikkontoret i Göteborg utfört luftkvalitetsmätningar på Friggagatan mellan 2013-01-01 och 2013-09-30. Dessutom utförde Miljöförvaltningen mätningar av dubbdäcksanvändningen på Friggagatan, vid Drottningtorget och i Haga. Vidare användes även mätdata f

Som vem som helst : Kön, funktionalitet och idrottande kroppar

Popular Abstract in Swedish Avhandlingens huvudsakliga syfte är att utforska unga kvinnors levda erfarenheter av en kropp som å ena sidan betraktas som avvikande – den fysiskt funktionsnedsatta eller rörelsehindrade kroppen – å andra sidan betraktas som presterande – den idrottande kroppen. De frågor som ställs i avhandlingen är hur de unga kvinnorna förhandlar de båda subjektspositioner som uppstThe main aim of this thesis is to explore young women’s lived experience of the body, which, on one hand, is viewed as deviant – the disabled body – and, on the other hand, is viewed as accomplished – the sporting body. The questions posed in the thesis are the following: how do the young women handle the two subject positions that emerge as a result of the perception of them as respectively devia