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Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci ha
This paper discusses unfortified thirteenth century palaces in Sweden. The palaces were unfortified already when built, and never became fortified before being abandoned. The palaces are analysed in relation to a power-grammar of architectural properties as well as the capitalization of the use of the past. It is argued that the absence of fortifications was a way for the medieval kings and royal
This Element is a contribution to a new generation of corpus pragmatics research by taking as its starting point the multifaceted nature of speech acts in conversation, and by adopting a mixed-methods approach. Through a unique combination of theoretical, qualitative, quantitative, and statistical approaches, it provides a detailed investigation of advice-giving and advice uptake in relation to (i
Serine deficiency disorders comprise a new group of inborn errors of serine metabolism. Patients affected with these disorders present with major neurological symptoms including congenital microcephaly, seizures, psychomotor retardation or polyneuropathy. The diagnosis of serine deficiency is based on the detection of low concentrations of the amino acids serine and glycine in fasted plasma and ce
Rather than exogenous endowments, natural resources can be seen as economically exploitable resources thanks to knowledge improvements. This underscores the need to understand why some natural resource abundant countries are able to develop their own technologies while others are not. We tackle this issue by looking at the evolution of engineering faculties and graduate engineers from 1850 to 1939
Dry, wet, dense, and dilute granular flows have been previously considered fundamentally different and thus described by distinct, and in many cases incompatible, rheologies. We carry out extensive simulations of granular flows, including wet and dry conditions, various geometries and driving mechanisms (boundary driven, fluid driven, and gravity driven), many of which are not captured by standard
In spite of the fact that negation has been the focus of many studies, the way it is processed in human communication still eludes us. Previous studies of negation using event-related potentials (ERPs) have reported inconclusive results as to whether or not negation poses difficulties for processing. While some have found that negation is initially ignored and incongruities in negated sentences do
Introduction of new myeloma therapies offers new options for patients refractory to immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). In this multicenter study, patients with relapsed multiple myeloma, who have received at least three prior lines of therapy, are refractory to both an IMiD (lenalidomide or pomalidomide) and a PI (bortezomib or carfilzomib), and have been exposed to an
BACKGROUND: Osteopenia, osteoporosis, and low bone mineral density are frequent in patients with HIV. We assessed the 96 week loss of bone mineral density associated with a nucleoside or nucleotide reverse transcriptase inhibitor (NtRTI)-sparing regimen.METHODS: Antiretroviral-naive adults with HIV were enrolled in 78 clinical sites in 15 European countries into a randomised (1:1), open-label, non
Diverse radiations of insects are often associated with adaptations to host plants, and well-resolved phylogenetic relationships are required to fully understand them. Palearctic Argynnis and related subgenera, together with North American Speyeria butterflies make up a radiation whose species hypotheses are confounded by shared wing colour patterns between sympatric populations of closely related
Political Data Yearbook
The acquisition of preverbal liaison (e.g. ils arrivent /ilzaʀiv/) in second language (L2) French has rarely been explored in detail in previous studies on obligatory liaison. In this study, we conducted an elicited imitation test in order to study the influence of proficiency level, modality (spoken or written), and verb frequency on the use of preverbal liaison among 42 Swedish learners of L2 Fr
In empirical research it is often of interest to include non-linear functions of the explanatory variables, such as squares or interactions, in the specification. A popular technique to estimate such models in the presence of common factors is the Common Correlated Effects (CCE) methodology. However, this approach assumes that the regressors are linear in the factors, which is not the case if vari
Lung transplantation is the only option for patients with end-stage lung disease, but there is a shortage of available lung donors. Furthermore, efficiency of lung transplantation has been limited due to primary graft dysfunction. Recent mouse models mimicking lung disease in humans have allowed for deepening our understanding of disease pathomechanisms. Moreover, new techniques such as decellular
