Filtyp
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci ha
This paper discusses unfortified thirteenth century palaces in Sweden. The palaces were unfortified already when built, and never became fortified before being abandoned. The palaces are analysed in relation to a power-grammar of architectural properties as well as the capitalization of the use of the past. It is argued that the absence of fortifications was a way for the medieval kings and royal
This Element is a contribution to a new generation of corpus pragmatics research by taking as its starting point the multifaceted nature of speech acts in conversation, and by adopting a mixed-methods approach. Through a unique combination of theoretical, qualitative, quantitative, and statistical approaches, it provides a detailed investigation of advice-giving and advice uptake in relation to (i
Dry, wet, dense, and dilute granular flows have been previously considered fundamentally different and thus described by distinct, and in many cases incompatible, rheologies. We carry out extensive simulations of granular flows, including wet and dry conditions, various geometries and driving mechanisms (boundary driven, fluid driven, and gravity driven), many of which are not captured by standard
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human postmortem MTL specimens with histology-based patho
The Common Correlated Effects (CCE) methodology is now well established for the analysis of factor-augmented panel models. Yet, it is often neglected that the pooled variant is biased unless the cross-section dimension (N) of the dataset dominates the time series length (T). This is problematic for inference with typical macroeconomic datasets where T often equal or larger than N. Given that an an
The standard cosmological model, the ΓCDM model, is the most suitable description for our universe. This framework can explain the accelerated expansion phase of the universe but still is not immune to open problems when it comes to the comparison with observations. One of the most critical issues is the so-called Hubble constant (H0) tension, namely, the difference of about 5σ as an average betwe
There are substantial concerns about impaired honey bee health and colony losses due to several poorly understood factors. We used MALDI profiling (MALDI BeeTyping®) analysis to investigate how some environmental and management factors under field conditions across Europe affected the honey bee haemolymph peptidome (all peptides in the circulatory fluid), as a profile of molecular markers represen
It has been proposed that formation of abdominal aortic aneurysm (AAA) is part of a systemic arterial dilatative disease. However, arteries in the upper extremity are scarcely studied and it remains unclear whether both muscular and elastic arteries are affected by the proposed systemic arterial dilatation. The aim of this study was to investigate diameter and stiffness of muscular and elastic art
Atrial Fibrillation (AF) is a type of cardiac arrhythmia that significantly increases the risk of stroke and heart failure. In general, in the case of patients affected by AF, their electrocardiogram (ECG) shows a typical pattern of irregular RR intervals and abnormal P waves. However, discriminating AF from a normal sinus rhythm or from other types of rhythms remains a challenging problem today.
An excess mortality is well described after vertebral fracture. Deaths are in part related to co-morbidity, but could also be due to the fracture event itself, either directly or indirectly. The aim of this study was to examine the quantum and pattern of mortality following vertebral fracture. We identified 16,051 men and women aged 50 years or more with a vertebral fracture that required hospital
Seven mols. isolated from lichen species were tested as antioxidants and photoprotectors of UV-B (280-315 nm.) radiation. Perlatolic acid was the best of these seven mols. The decarboxythamnolic, usnic and usnic acid deriv. showed activity as photoprotectors. Finally, thamnolic acid showed good scavenging activity.
