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SN-ENUJ230013 1..15 Disorders of the Nervous System Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease Soophie Olfat,1,2,p Kärt Mätlik,2,p Jaakko J. Kopra,3 Daniel R. Garton,2 Vilma H. Iivanainen,2 Dipabarna Bhattacharya,2 Johan Jakobsson,4 T. Petteri Piepponen,3 and Jaan-Olle Andressoo1,2 h
TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity PNAS 2024 Vol. 121 No. 47 e2410331121 https://doi.org/10.1073/pnas.2410331121 1 of 12 RESEARCH ARTICLE | Significance Understanding the molecular basis of dopaminergic (DA) neuron diversity is crucial for both experimental work and clinical applications. Here, we present a comprehensive
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/2024-11/publication_PNAS.pdf - 2026-07-11
Roasted cassava roots flour is part of a common meal in Africa, it is known as rale in Mozambique. Fifty six samples of rale were collected from homes and markets in Inhambane Province, Mozambique, for cyanogenic potential (CNp) analyses. The names of cassava varieties used for preparing the rale samples could be determined in the home-collected samples, three varieties were recorded. Xinhembwe va
The effects induced by Na deposited on furnace grown graphene on SiC(0001) and after subsequent annealing are investigated using LEEM, mu-LEED, mu-PES and XPEEM. Intercalation in between carbon layers and at the interface is observed to occur both on the 1 ML and 2 ML areas directly after Na deposition. Annealing at a temperature around 100 degrees C is found to strongly promote Na intercalation.
The European research project ‘Experiences of Children from Rainbow Families in School’ (2009 – 2011) conducted by researchers from Humboldt-Universität zu Berlin, Germany (Centre for Transdisciplinary Genderstudies), University Ljubljana, Slovenia (Department of Social Justice and Inclusions, Faculty of Social Work) and Lund University, Sweden (Centre for Gender Studies) focuses in its comparativ
Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use. We revisited the hypothesis that minocycline acts through direct inhibition of calcium-induced mitochondrial permeability transition (mPT) resulting in reduced release of cytochrome c (cyt c). Minocycline, at high dosage, was found to prevent calcium
EXAFS spectroscopy was used to study Pb(II) and Hg(II) adsorption complexes on goethite (alpha-FeOOH) in the presence of Cl-. At pH 7, the dominant Pb(II) species are bonded to edges of FeO6 octahedra and are similar to complexes that occur in the absence of Cl-. At pH less than or equal to 6, Pb(II)-chloro ternary complexes predominate and are bonded to corners of FeO6 octahedra. At pH 6.5, linea
Photochemical reactions rationalization is a key aspect for the understanding and setup of novel experiment and novel photoinitiated pathways. In this respect, the relationship between minimum energy paths over an excited-state and the intersection to lower potential energy surfaces is fundamental. In order to help the understanding of this relationship, in this study we present a novel kind of co
Nearly half of mammalian genomes are derived from ancient transposable elements (TEs). We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs and found evidence suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals. Furthermore, we found that recently expanded gene classes, such as those involved in immunity o
Fe-only hydrogenases are enzymes that catalyze dihydrogen production or oxidation, due to the presence of an unusual Fe6S6 cluster (the so-called H-cluster) in their active site, which is composed of a Fe2S2 subsite, directly involved in catalysis, and a classical Fe4S4 cubane cluster. Here, we present a hybrid quantum mechanical and molecular mechanical (QM/MM) investigation of the Fe-only hydrog
