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The dynamic regulation of ligand binding is considered crucial for integrin function. However, the importance of activity regulation for integrin function in vivo is largely unknown. Here, we have applied gene targeting to delete the GFFKR sequence of the lymphocyte function-associated antigen-1 (LFA-1) alpha(L) subunit cytoplasmic domain in mouse germline. Lymphocytes from Lfa-1(d/d) mutant mice

Objective: To review research articles in psychiatry and psychology involving Latin American populations and/or produced by Latin American scholars to investigate the differential diagnosis between spiritual/anomalous experiences and mental disorders in order to contribute to the validity of the International Classification of Diseases towards its 11(th) edition in this area. Method: We searched e

At present, the climate in south-west Scandinavia is predominantly controlled by westerlies carrying moist Atlantic air, which forms a main source of precipitation in all seasons. Past variations in the ratio between precipitation and evaporation (effective precipitation) from terrestrial sites, however, may indicate changes in the degree of maritime influence. Palaeoclimatic archives in this regi

Cores taken from an ombrotrophic peat bog in the coastal zone of Halland, southwest Sweden, were examined for wind transported mineral grains, pollen and humidity indicators. The core covers the period from 6500 cal. yr BP to present. Ombrotrophic conditions existed from ca. 4200 cal. yr BP onwards. Bog surface wetness fluctuated strongly until ca. 3700 cal. yr BP, with an apparent dominance of dr

In the set of commentaries on liquidity entitled “The continuing significance of social structure in liquid modernity,” three sets of authors set out to examine the relationship between liquidity and structure, value, and distinction. In doing so, they attempt to marry theories which argue against sociologist Zygmunt Bauman’s central thesis that societal structures are shifting with his seminal co

We give an expression for the Garsia entropy of Bernoulli convolutions in terms of products of matrices. This gives an explicit rate of convergence of the Garsia entropy and shows that one can calculate the Hausdorff dimension of the Bernoulli convolution νβ to arbitrary given accuracy whenever β is algebraic. In particular, if the Garsia entropy H(β) is not equal to log(β) then we have a finite t

We discuss the associated cc¯ and l+l- pairs production in ultraperipheral heavy-ion collisions at high energies. Such a channel provides a novel probe for double-parton scattering (DPS) at small x enabling one to probe the photon density inside the nucleus. We have derived an analog of the standard central pp pocket formula and studied the kinematical dependence of the effective cross section. Ta

This paper presents the results of a qualitative study of user behaviour on the World-Wide Web. Eight participants were filmed whilst performing user-defined tasks and then asked to review the video-taped session during prompted recall. This data forms the basis for a series of descriptions of user behaviour and the postulation of a number of underlying cognitive mechanisms. Our results indicate t

Supervaluationism holds that the future is undetermined, and as a consequence of this, statements about the future may be neither true nor false. In the present paper, we explore the novel and quite different view that the future is abundant: statements about the future do not lack truth-value, but may instead be glutty, that is both true and false. We will show that (1) the logic resulting from t

Hemp (Cannabis sativa) is an agricultural crop that can be used as a building material in combination with lime and cement. A composite building material that combines a cementitious binder (building limes and cement) with hemp shives, the woody core of the hemp stalk is generally referred to as hemp concrete (HC). However, industrial facilities to separate hemp shives and fibres are currently not