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BACKGROUND: Because hemodilution decreases the oxygen-carrying capacity of blood, it was hypothesized that severe hemodilution would decrease the tolerance to alveolar hypoxia. METHODS: Hemodynamics, oxygen transport, and blood lactate concentrations were compared in ten pigs with normal hematocrit (33 +/- 4%), and ten hemodiluted pigs (hematocrit 11 +/- 1%; mean +/- SD) anesthetized with ketamine
Abstract Toxic cyanobacterial blooms can form in both freshwater and marine environments, which could threaten the health of human beings and animals. The genera that are known for causing the scums in freshwater are Anabaena, Microcystis, Cylindrospermopsis and Planktothrix. In order to control lake water quality and minimize the potential health risk associated with the cyanobacterial blooms, th
Objective: To identify possible suicide risk factors in a clinical sample and suicide risk in a general population, with primary focus on mental disorders, signs, symptoms and comorbidity. Methods: In the first two studies, subjects who had been admitted to a specialised psychiatric ward after a suicide attempt were investigated. Fifteen suicide completers were compared to matched survivors in te
This thesis deals with the death of the thralls at their owners’ burial in the Nordic countries during the late Iron Age. In literary sources such as the Icelandic Sagas and Ibn Fadlan, it is told that thralls were killed at the funeral of their owner, and buried with them. It is inferred that the thrall may have had a choice, and that they chose death. However, certain graves from c:a 700-900 A.D
Laminins are heterotrimeric glycoproteins of the basement membranes. Laminin 1 (alpha 1, beta 1, gamma 1) is the major laminin expressed during early mouse embryogenesis. To gain access, to the physiological function of laminin alpha 1 chain, we developed a conditionally null allele of its encoding gene (Lama1) using the cre/loxP system. Floxed-allele-carrying mice (Lama1(flox/flox)) display no ov
We have analyzed the development of aortic and coronary atherosclerosis over 40 years in native and non-native males of Yakutsk by comparing the data obtained in 1963-1965, 1985-1987 and 2001-2003. The research was carried out in compliance with the WHO program for the atherosclerosis epidemiology studies using autopsy material. Subjects (361 natives and 692 non-natives) included in the research d
A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having recei
Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is known about the relationship between misfolded α-synuclein and endothelial function.
This article addresses the causes and motives behind the Soviet decision to hand over the Vyshinskii note to the Swedish government in August 1947. In this note, signed by Deputy Foreign Minister Andrei Ia. Vyshinskii, it was falsely claimed that the whereabouts of the Swedish diplomat Raoul Wallenberg, who had been arrested by the Soviet military counterespionage death to the spies (Smersh) on 17
During the last two decades, survival rates after cardiac arrest have increased while the fraction of patients surviving with a severe neurological disability or vegetative state has decreased in many countries. While improved survival is due to improvements in the whole chain of survival, improved methods for prognostication of neurological outcome may be of major importance for the lower disabil
Anticoagulant treatment of acute pulmonary embolism (PE) has traditionally been hospital-based. The lesser need for monitoring with the increasingly used direct acting oral anticoagulants (DOAC) in comparison to warfarin potentially facilitates outpatient treatment of PE with these drugs. This study aimed to evaluate efficacy and safety of outpatient treatment of PE with DOAC. We extracted data fr
Introduction: Preoperative smoking intervention programmes reduce post‐operative complications in smokers. Little is known about the long‐term effect upon smoking cessation. Aim: To discover long‐term quit rates and the reasons behind successful cessation. Materials and Methods: 101 one of 120 smokers, randomised to smoking intervention or no intervention before hip and knee surgery, completed que
Background: For locally advanced Siewert type II and III tumors we have performed total gastrectomy including resection of the distal 2/3 of the esophagus, through separate abdominal and right chest incisions (THX-ABD). The procedure involves wide lymphadenectomy in the abdomen/chest and a Roux-en-Y jejunostomy to the level of the azygos vein or above. The aim of the study was to investigate short
