Filtyp
Purpose To explore the effect of high-dose ifosfamide in first-line treatment for patients <= 40 years of age with nonmetastatic osteosarcoma of the extremity. Patients and Methods From March 1997 to September 2000, 182 patients were evaluated. Primary treatment consisted of two blocks of high-dose ifosfamide (15 g/m(2)), methotrexate (12 g/m(2)), cisplatin (120 mg/m(2)), and doxorubicin (75 mg/m(
Context:Patients with hypopituitarism have an increased standardized mortality rate. The basis for this has not been fully clarified.Objective:To investigate in detail the cause of death in a large cohort of patients with hypopituitarism subjected to long-term follow-up.Design and Methods:All-cause and cause-specific mortality in 1286 Swedish patients with hypopituitarism prospectively monitored i
BACKGROUND: We have previously developed (11)C-erlotinib as a new positron emission tomography (PET) tracer and shown that it accumulates in epidermal growth factor receptor (EGFR)-positive lung cancer xenografts in mice. Here, we present a study in patients with non-small cell lung cancer (NSCLC) investigating the feasibility of (11)C-erlotinib PET as a potential method for the identification of
'Men born in 1914' is a population-based cohort study of the epidemiology of cardiovascular disease. Twenty-five percent of the men had moderate or severe (> 30%) carotid artery stenosis (CAS) at 68 years of age. The objective of this study was to study the incidence and progression of disease from 68 to 81 years of age in relation to major risk factors for atherosclerotic disease. Five hundred me
Purpose: To investigate the global burden of sepsis in hospitalized adults by updating and expanding a systematic review and meta-analysis and to compare findings with recent Institute for Health Metrics and Evaluation (IHME) sepsis estimates. Methods: Thirteen electronic databases were searched for studies on population-level sepsis incidence defined according to clinical criteria (Sepsis-1, -2:
The patients’ burden of comorbidities is a cornerstone in risk assessment, clinical management and follow-up. The aim of this study was to evaluate if biomarkers associated with comorbidity burden can predict outcome in acute dyspnea patients. We included 774 patients with dyspnea admitted to an emergency department and measured 80 cardiovascular protein biomarkers in serum collected at admission.
Background: Non-participants to psychosocial studies have been shown to have higher mortality, and mortality differs between partial and complete responders to psychosocial questionnaires. Yet, there is very little information available directly linking survey response status with completing suicide. Methods: The study population consisted of the participants of the Japanese Public Health Center-b
OBJECTIVES: The purpose of this study was to determine whether statin treatment is effective and safe in very elderly (80 years and older) acute myocardial infarction (AMI) patients. BACKGROUND: Elderly individuals constitute an increasing percentage of patients admitted to hospitals for AMI. Despite that these patients have a higher mortality risk, the application of evidence-based medicine remai
Background: Although recent population-based studies suggest a U-shaped relationship between serum IGF-I concentration and all-cause mortality, the distribution of death causes underlying this association remains unclear. We hypothesized that high IGF-I levels associate with increased cancer mortality, whereas low IGF-I levels associate with increased cardiovascular disease (CVD) mortality. Metho
OBJECTIVE: Therapeutic hypothermia (TH) is a recommended treatment for survivors of cardiac arrest. Prognostication is complicated since sedation and muscle relaxation are used and established indicators of a poor prognosis are lacking. This prospective, observational study describes the pattern of commonly used prognostic markers in a hypothermia-treated cohort of cardiac arrest patients with pro
Background: Body dysmorphic disorder (BDD) is thought to be associated with considerable suicide risk. This nationwide cohort study quantified the risks of intentional self-harm—including nonsuicidal self-injuries and suicide attempts—and death by suicide in BDD. Methods: Individuals with a validated ICD-10 diagnosis of BDD in the Swedish National Patient Register, registered between January 1, 19
In multiple myeloma (MM), advancements in treatments and toxicity management have enhanced survival rates. This, coupled with shifting age demographics in MM, necessitates an updated assessment of infection risks in MM patients compared to the general population. Using Swedish population-based registries, we investigated the incidence of infections in 8,672 Swedish symptomatic MM patients diagnose
Världsdiabetesdagen firas den 14 november, Frederick Bantings födelsedag. Han har fått äran av att 1921 ha upptäckt insulinet. För nästan 2000 år sedan gav den turkiske läkaren Aretaios sjukdomen sitt namn. ”Det syns mig som om sjukdomen bör kallas diabetes – något som liknar ett vattenrör, därför att vätskan inte stannar i kroppen utan använder människan som ett vattenrör, genom vilket den rinner
https://www.diabetesportalen.lu.se/om-diabetes/diabeteshistoria/diabetes-en-underlig-sjukdom - 2026-07-11
Aurora Dumitrescu, author of two novels, Cagliostro and The Bipolar(Tracus Arte Press, 2016). The Bipolar places its action in the contemporary world and applies not very different narrative techniques. The similarity in parallel readings shows that the Coelho model is obvious, but I would saythat Aurora Dumitrescu respects more her readers, as she stimulates their intelligence too. The only hono
Den aktuella studiens syfte var att undersöka om det finns ett samband mellan upptagenhet av kost och träning och fyra psykologiska faktorer: hälsoångest, självkänsla, känsla av sammanhang och kroppsuppfattning, då psykiskt välmående som begrepp är alltför mångfacetterat. Ett ytterligare syfte var att undersöka om upptagenhet av kost och träning skiljde sig åt beroende på specifika egenskaper hos The purpose of the present study was to examine whether there are connections between preoccupation with diet, and exercise, and four psychological factors: health anxiety, self-esteem, sense of coherence, and body image, since psychological well- being is a broadly used term. Another aim was to examine whether the preoccupation with diet, and exercise differed depending on some specific character
Twitter har beskrivits som ett relevant verktyg för svenska politiker för att hålla sig uppdaterade kring vad som händer inom den politiska världen. Twitter som kanal har tidigare benämnts som ett elitmedium, då det finns en stark närvaro av opin-ionsbildare av olika slag. Det är alltid viktigt att granska makthavares kommuni-kation och hur detta kan påverka demokratin. Vi har genomfört en kvalitaTwitter has been described as a must-have tool for Swedish politicians, to not fall behind in the constant flow of information. Previous research has defined Twitter as an elitist channel, due to its dense population of opinion-makers. It is important to keep a critical approach towards how people in power communicate and what possible effect their communications might have on the democratic proce
