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Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs
BACKGROUND: Type 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has been shown to be increased in T2D plaques and suggested to contribute to plaque ruptures. Despite intensified statin treatment during the last decade the higher risk for events remains. Here, we explored if intensified statin treatment was associated
Objectives: Previous large studies of contrast-induced or post-contrast acute kidney injury (CI-AKI/PC-AKI) have been observational, and mostly retrospective, often with patients undergoing non-enhanced CT as controls. This carries risk of inclusion bias that makes the true incidence of PC-AKI hard to interpret. Our aim was to determine the incidence of PC-AKI in a large, randomly selected cohort,
Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted fo
Objective: To explore how cancer survivors have experienced their contacts with primary care after being diagnosed with cancer, focusing on the integration between cancer specialist and primary care, and participants’ views on what could make primary care services better at catering to the needs of cancer survivors. Design: A qualitative study in which data was collected through semi-structured di
The widespread occurrence of lower Eocene chert and porcellanite has been viewed as a major paleoceanographic issue since the advent of ocean drilling, and both biotic and abiotic forcings have been proposed to explain it. We present a reconstruction of indurated siliceous sediment (ISS) and preserved biosiliceous sediment (PBS) occurrences in the Atlantic Ocean through the Paleocene and Eocene (~
Electrical resistivity tomography (ERT) can be used to monitor the interior of hydropower embankments dams, and thereby detect zones with anomalous material properties and flow induced variation in the resistivity caused by changes in total dissolved solids (TDS) and temperature. Furthermore, monitoring of embankment dams in connection with a substantial change in the reservoir water level can det
Background: If individual differences are relevant and prominent features of personality, then they are expected to be encoded in natural language, thus manifesting themselves in single words. Recently, the quantification of text data using advanced natural language processing techniques offers innovative opportunities to map people’s own words and narratives to their responses to self-reports. He
Background Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1-2a study. Methods We conducted a phase 3 open-label study of fidanacogene elaparvovec at a dose of 5×1011 vector genome copies per kilogram of body weight. Me
Objectives: We explored the prevalence of health complaints subjectively associated with static magnetic field (SMF) and acoustic noise exposure among MR radiographers in Sweden, using CT radiographers as a control group. Additionally, we explored radiographers’ use of strategies to mitigate adverse health effects. Methods: A cross-sectional survey was sent to all hospitals with MR units in Sweden
Microbial necromass contributes significantly to both soil carbon (C) persistence and ecosystem nitrogen (N) availability, but quantitative estimates of C and N movement from necromass into soils and decomposer communities are lacking. Additionally, while melanin is known to slow fungal necromass decomposition, how it influences microbial C and N acquisition as well as elemental release into soils
Background: Family is a crucial social institution in end-of-life care. Family caregivers are encouraged to take on more responsibility at different times during the illness, providing personal and medical care. Unpaid work can be overburdening, with women often spending more time in care work than men. Objectives: This study explored multiple views on the family’s role in end-of-life care from a
Hemiparasitic plants accumulate nutrients in their leaves and therefore produce high-quality litter with faster decomposition and nutrient release rates compared to non-parasitic litter. Higher levels of plant-available nitrogen (N) in the presence of hemiparasitic plants have been attributed to this 'litter effect', but effects on N dynamics in the soil remain unstudied. We tested the hypothesis
Areal bone mineral density (aBMD), as measured by dual-energy X-ray absorptiometry (DXA), predicts hip fracture risk only moderately. Simulation of bone mechanics based on DXA imaging of the proximal femur, may help to improve the prediction accuracy. Therefore, we collected three (1-3) image sets, including CT images and DXA images of 34 proximal cadaver femurs (set1, including 30 males, 4 female
OBJECTIVE: To prospectively describe self-reported outcomes up to 5 years after total knee replacement (TKR) in Osteoarthritis (OA) and to study which patient-relevant factors may predict outcomes for pain and physical function (PF). METHODS: 102 consecutive patients with knee OA, 63 women and 39 men, mean age 71 (51-86) assigned for TKR at the Department of Orthopaedics at Lund University Hospita
This dissertation is a contribution to the knowledge of the computational complexity of discrete combinatorial problems. 1. The first problem that we consider is to compute the maximum independent set of a box graph, that is, given a set of orthogonal boxes in the plane compute the largest subset such that no boxes in the subset overlap. We provide an $mathtt{exp}(O(sqrt nlog n))$-time algorithm
In the last few years, we have seen an emerging activity among library institutions to release their catalogue data under the terms that are often referred to as “linked, open data”. The linked, open data concept brings some new features to the practice of bibliographic data exchange: It is done in a linked data environment following the technical principles of what is called the “semantic web”. I
India has yet to build 70% of the buildings that will exist in 2030. The housing industry in India has been growing rapidly in an effort to keep up with increasing urbanization, population growth and aspirational consumption. Its growth is accompanied by a large ecological footprint, given the resource intensive processes involved and the large amount of greenhouse gas emissions (GHG) produced. St
In this work, which is to be used as a supplementary example to the educational literature in Automatic Control, at LTH, I have chosen one reactor, in the group of chemical reactors, for the examination. The chosen reactor is the continuos-flow, autothermic, nonadiabatic stirred-tank reactor. Required cooling of the reaction mixture is achieved by letting the reactor-tank be surrounded by a coolin
The purpose of this thesis is to examine nanowires made up of compound III-V-semiconductors which can be applied as photovoltaic devices. Two types of experiments are done approaching from two different starting points: Firstly, studies of several III-V-semiconductor wafer surfaces used as a reference for studies of nanowire surfaces and secondly, direct contacting of standing nanowires in order t
