Filtyp
The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMRCys) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy individu
Light to the Nations is a work created by Yael Bartana which combines different media such as sculpture, VR, and video animation, as well as a learning center.It is a proposal about the attempts, dystopic and utopic, to save humanity in the face of a global catastrophe, whether man-made or caused by nature, which would extinguish any possibility of life on Earth. The work is influenced by post-ap
’Screen time’ has become a catch-all concept for debates on people’s dependence of digital devices in general, and children’s use of media technology in particular, almost exclusively focusing on negative consequences. While children and young people more often than not are at the center of debates around screen time, parents and their everyday practices are held accountable for monitoring, regula
This explorative literature review aims to examine the content and methodologies of recent empirical studies on the aspirations of youth in situations of migration in Europe. The search yielded 30 peer-reviewed social science publications in English for the period 2010–2022, including both intra-European migrants ages 10–24 and youth with backgrounds from outside Europe. Contextual analysis was us
Traumatic brain injury (TBI) is a major cause of morbidity and mortality, not least in the elderly. The incidence of aged TBI patients has increased dramatically during the last decades. High age is a highly negative prognostic factor in TBI, and pharmacological treatment options are lacking. We used the controlled cortical impact (CCI) TBI model in 23-month-old male and female mice and analyzed t
Background and purpose: Since patients with primary brain tumor are expected to become long-term survivors, the prevention of long-term treatment-induced side effects is particularly important. This study aimed to explore whether symptom experience and symptom distress change over five years in adults with primary brain tumors treated with proton therapy. An additional aim was to explore whether s
In circumpolar regions, coastlines offer rich constellations of diverse resources, and have long been a focus of human habitation. Despite the rich archaeological records that are located along many northern coastlines, there is a relatively limited understanding of the range of factors that informed local settlement strategies. Northern Norway has one of the world’s longest and best-preserved arc
Treatment of bladder cancer has seen few advancements in recent decades until the introduction of checkpoint inhibitors during the last few years. Bladder cancer diagnostics have been similarly impaired and the likely advent of novel treatments in the neoadjuvant setting will require new diagnostic tools in the preoperative setting in muscleinvasive bladder cancer.This thesis evaluates three diagn
Excessive daytime sleepiness (EDS) is a factor associated with both obstructive sleep apnea (OSA) and depressive symptoms. Continuous positive airway pressure (CPAP) treatment may decrease EDS in adults with OSA; however, the modulatory role of depressive symptoms on the improvement of EDS is not known. We aimed to explore the association between subscales of the Zung Self-rated Depression Scale (
Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibito
OBJECTIVE: Lower limb lymphedema (LLL) is a chronic condition. To be able to evaluate changes of LLL over time and effects of interventions reliable measurement methods are important. Currently, there is limited knowledge of the reliability of commonly used measurement methods in LLL. The study objective was to evaluate the test-retest (intrarater) reliability of impedance of extracellular fluid,
Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma
Background: Retrospective studies indicate that the choice of anesthetic can affect long-term cancer survival. Propofol seems to have an advantage over sevoflurane. However, this is questioned for breast cancer. We gathered a large cohort of breast cancer surgery patients from seven Swedish hospitals and hypothesized that general anesthesia with propofol would be superior to sevoflurane anesthesia
We present an approach for the estimation of ore processing residue volumes in historical mine waste dumps by the use of different geophysical methods in combination with mineralogical investigations. The stamp mill dump in the Harz mountains, Germany was examined with the methods electrical resistivity tomography (ERT), ground penetrating radar (GPR) and spectral induced polarization (SIP) flanke
Background: Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding and activating several estrogen receptors (ERs). Calcitonin gene-related peptide (CGRP) has a strong position in migraine pathophysiology, and interaction with CGRP has resulted i
Objectives: To develop a generic and objective tool for assessing competence in percutaneous ultrasound-guided procedures. Methods: Interventional ultrasound experts from the Nordic countries were invited to participate in a three-round Delphi process. A steering committee was formed to manage the process. In round 1, the experts were asked to suggest all aspects to consider when assessing compete
Consider the subspace Wn of L2(C, dA) consisting of all weighted polynomials W(z)=P(z)·e-12nQ(z), where P(z) is a holomorphic polynomial of degree at most n- 1 , Q(z) = Q(z, z¯) is a fixed, real-valued function called the “external potential”, and dA=12πidz¯∧dz is normalized Lebesgue measure in the complex plane C. We study large n asymptotics for the reproducing kernel Kn(z, w) of Wn; this depend
PURPOSE: Water saturation shift referencing (WASSR) Z-spectra are used commonly for field referencing in chemical exchange saturation transfer (CEST) MRI. However, their analysis using least-squares (LS) Lorentzian fitting is time-consuming and prone to errors because of the unavoidable noise in vivo. A deep learning-based single Lorentzian Fitting Network (sLoFNet) is proposed to overcome these s
AimsInfection is a serious complication of cardiac implantable electronic device (CIED) therapy. An antibiotic-eluting absorbable envelope has been developed to reduce the infection rate, but studies investigating the efficacy and a reasonable number needed to treat in high-risk populations for infections are limited.Methods and resultsOne hundred and forty-four patients undergoing CIED implantati
Objective: To analyze the effectiveness and safety of growth hormone (GH) replacement treatment in adult patients with Langerhans cell histiocytosis (LCH) and GH deficiency (GHD) enrolled in KIMS (Pfizer International Metabolic Database). Patients and methods: Patients with LCH and GHD were studied at baseline and some of them after 1 year of GH treatment. The effectiveness of GH is presented as c
