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Type-2 diabetes (T2D) is a complex disease characterized by insulin resistance in target tissues and impaired insulin release from pancreatic beta cells. As central tissue of glucose homeostasis, the pancreatic islet continues to be an important focus of research to understand the pathophysiology of the disease. The increased access to human pancreatic islets has resulted in improved knowledge of
The objective of this prospective cohort study was to describe real-life use of lipid-lowering drugs and low-density lipoprotein cholesterol (LDL-C) target-attainment rates 1 year after acute myocardial infarction (AMI). LDL-C was recorded at hospital admission for AMI and at follow-up at 2 and 12 months after AMI in 17,236 patients in the Swedish heart registry, SWEDEHEART, from 2004 through 2009
Palovarotene is an oral gamma-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. REPAIR (Retinoid treatment of Emphysema in Patients on the alpha(1)-antitrypsin International Registry), was an investigator-initiated, double-blind, placebo-controlled randomised study to assess the safety and efficacy of 5
We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100mg QD or imatinib 400mg QD and report outcome as an intention-to-treat analysis with 36months follow-up. Early cytogenetic and molecular responses were superior in the dasatinib group, with a tendency that imatinib patients caught up with time. For instance, MR3.0 was reached at 3months
Abstract Objective. This study examined whether age, gender, and comorbidity were of importance for an individual's choice of listing with either a public or a private primary health care (PHC) practice. Design and setting. The study was a register-based closed cohort study in one private and one public PHC practice in Blekinge County in southern Sweden. Subjects. A cohort (12 696 individuals) was
PURPOSE: The Dutch national guideline for Cardiovascular Risk Management advised in 2006 initiation of statin therapy in new patients with simvastatin. After the introduction of this guideline several measures were taken to increase the prescription of simvastatin in general practice. The aim of this paper is to describe the trend and interpractice variation in the relative share of simvastatin in
The phenomenon of increased bee mortality has reached wide attention and concern among Swiss farmers. This thesis analyses, from a phenomenological approach, how the farmers - as agricultural key actors interacting closely with honey bees - perceive increased bee mortality as a risk. The quantitative analysis indicates that the age, the perception of the future of global agriculture and all farm
Marknaden för kontor är till stor del beroende av läget av fastigheterna. Det finns stora skillnader i hyresnivåer mellan olika lägen och vad som gör att företag har en högre betalningsvilja för vissa lägen beror på flera lägesfaktorer. Syftet med studien är att identifiera lägesfaktorer som har betydande påverkan på hyresnivåer. Vidare är syftet att kvantifiera och analysera värdepåverkan. Genom The market for offices in urban environments is largely dependent on the location of the properties. There are differences in the level of office rents depending on location, characteristics and attributes in the location. The purpose of the study is to identify the location attributes that have a significant impact on rental levels. Furthermore, the aim is to quantify and analyse the impact value
The growing use of wind energy as major energy source, has led to the construction of large wind farms. The control of such wind farms is typically separated into control at wind turbine level and at wind farm level. The wind farm controller assures that the wind farm produces the demanded amount of power, by providing set-points for the turbines in the farm. The local turbine control assures that
Physics-informed neural networks integrate physical laws into machine learning models to solve differential equations. This thesis investigates an inverse physics-informed neural network framework for estimating viscosity in Tetra Pak’s injection molding process, where direct measurements are not possible. By enforcing the Navier-Stokes equations and using sparse velocity and pressure data, a virt
Adaptation strategies can backfire and cause maladaptive outcomes, yet this is an understudied area in Swedish adaptation work, and a conceptually challenging theme with potential justice implications. The study explored the potential existence of maladaptation in Swedish municipalities in the Motala ström catchment area in collaboration with the FairWater research project, through conducting 18 q
This thesis investigates whether European industrial firms issuing green bonds enjoy a borrowing-cost advantage, so called a “greenium.” Using a sample of 1,305 euro-denominated issues from 2014 to mid-2025, we estimate fixed-effects OLS regressions of yield-to-maturity on a green-bond indicator, controlling for tenor, issuer size, leverage, interest coverage, credit rating, industry, issuer, and
This is a translation of the course syllabus approved in Swedish School of Economics and Management EEH017F, Applied Time Series Analysis,7.5 credits Tillämpad tidsserieanalys, 7,5 högskolepoäng Third Cycle / Doktorandnivå Details of approval Approved by the Board of the Department of Economic History, Lund University School of Economics and Management 2021-03-09. General Information This is an op
https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-05/Applied%20Time%20Series%20Analysis_EEH017F_Syllabus.pdf - 2026-07-23
Aim: The present investigation was designed to evaluate the health-related quality of life (HRQOL) of adolescents with asthma between the age of 16 and 21, when they are transferred from paediatric to adult care. Methods: In this prospective study, 156 teenagers (69 females) with asthma were screened employing spirometry, a histamine challenge, skin prick test for allergy and filled out the 'Liv
The low-temperature structural phase transitions of Bi, Pb, In and Sn-doped samples of thermoelectric Zn 4 Sb 3 have been characterized on crystals grown from molten metal fluxes, using electrical resistance and single crystal X-ray diffraction measurements.
Background: The aims of this study were to present the psychometric properties of a newly designed cognitive screening instrument, the Multicultural Cognitive Examination (MCE), and to compare it with the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural population. Methods: The study was a Western European cross-sectional multicenter study. The MCE consists of four components
Background: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. Aim of the study: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall pre
The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin
