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The ex vivo large animal retina is extensively used in research ranging from discovery of disease mechanisms to future treatment paradigms. Due to limited standardization when harvesting the tissue, the time after enucleation is often ex- tended for several hours, a factor that so far has not yet been fully characterized. The purpose of this study was to investi- gate the relationship between time
Objective: More than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes. Methods: Patients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined
Purpose Despite data showing breathlessness to be more prevalent in older adults, we have little detail about the severity or multidimensional characteristics of breathlessness and other self-reported measures (such as quality of life and other cardiorespiratory-related symptoms) in this group at the population level. We also know little about the relationship between multidimensional breathlessne
INTRODUCTION: The aim was to investigate psychiatric health care utilization two years before death by suicide among individuals with previous suicide attempts (PSA) compared with those without (NSA).METHOD: A retrospective population-based cohort study was conducted including 484 individuals who died by suicide in Sweden in 2015 and were in contact with psychiatric services within the two years p
BACKGROUND: Surgery for total colonic aganglionosis (TCA) is designed to preserve continence and achieve satisfactory quality of life. This study evaluated a comprehensive group of clinical and social outcomes.METHODS: An international multicentre study from eight Nordic hospitals involving examination of case records and a patient-reported questionnaire survey of all patients born with TCA betwee
ObjectivePediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought to reflect mechanisms that cut across mental disorders. Whether p predicts outcom
Objective: Oesophageal atresia is an congenital anomali with incidence of 1/3000-1/4500 live births. The results of reconstructive surgery has improved greatly, to 80-92% survival reported in the last two decades. The aim of this study was to determine the incidence of oesophageal atresia in Iceland and to evaluate the results of operations at the Department of Pediatric surgery at The Children's
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed against the nuclear antigens will form large immune complexes (ICs) which are central in the immunop
Background: There are limited prognostic data for locally advanced prostate cancer PCa to guide in the choice of treatment. Objective: To assess mortality in different prognostic categories among men with locally advanced PCa managed with noncurative intent. Design, setting, and participants: We conducted a register-based nationwide cohort study within the Prostate Cancer DataBase Sweden. The enti
DynahMat is an ongoing project at the Packaging Logistics department at Lund University, which aims to reduce food waste by establishing the true quality and shelf life of chilled goods through a dynamic shelf life prediction (DSLP) service. The idea behind the service is, throughout the entire supply chain, to measure temperature and microbial growth using sensors attached to the package. The inf
The purpose of this Master’s thesis has been to establish a method with which the stochastic field for the hydraulic conductivity within an aquifer can be determined. The stochastic field is characterised by the mean value and the standard deviation of the hydraulic conductivity together with a selected statistical distribution and the correlation between different points within the aquifer. The a
I familjerätten finns två former av vårdnad, ensam vårdnad och gemensam vårdnad. Den sistnämnda vårdnadsformen utgör utgångspunkten vid bedömningen av vilken vårdnadsform som är lämpligast. En utgångspunkt som har varit så stark att den har gett upphov till en presumtion för gemensam vårdnad. Uppsatsen undersöker den gemensamma vårdnadens rättsutveckling med utgångspunkt i vårdnadsreformerna 199Within the area of family law there exists two forms of legal child custody, sole custody and joint custody. The last form is the starting point in court when deciding upon which form of custody constitutes the most suitable one. The strength of the previously mentioned starting point are of such degree that a presumption for joint custody took shape. The essay examines how the development of chi
Uppsatsen behandlar kommunal delegation och speciellt den myndighetsutövning mot enskild som sker på socialrättens område. Framförallt gäller myndighetsutövningen tvångsomhändertaganden och ansökan om tvångsvård enligt LVU. Uppsatsen består av en deskriptiv del där gällande rätt avseende kommunal delegation utreds. Begrepp som behandlas är bland annat ren verkställighet, beslut, lekmannastyrning, This thesis deals with municipal delegation and in particular the excercise of authority over individuals within the field of social law. Said exercise of authority primarily concerns compulsive preventive detention and applications for compulsory care under LVU. The thesis consists of a descriptive part where the applicable law regarding municipal delegation is investigated. Concepts covered incl
Background: The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net. Methods: We conducted a retrospective cohort study of adult
Background: The treatment strategy for proximal aortic disease or type I endoleak after previous infrarenal repair has traditionally been open surgery. As endovascular treatment options with fenestrated and branched stent grafts increasingly rival open surgery for juxtarenal and pararenal aortic aneurysms, secondary proximal repair may similarly be performed endovascularly. Fenestrated stent graft
Serum levels of Anti-Mullerian Hormone (AMH) have been shown to be biomarker for prediction of the quantitative aspects of ovarian reserve. On the male side, sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI) has been demonstrated to be an important predictor of outcomes in standard IVF procedures but to less degree in intracytoplasmic sperm injection procedures (ICSI). The purpo
Introduction: Tpeak-Tend interval (Tpe) is considered to be an ECG reflection of the dispersion of repolarization (DOR), and as such has been proposed as a predictor of arrhythmias. In ischemia, robustness of the Tpe-DOR relationship may suffer from variability of the myocardium at risk (MaR) area. In the present study, we evaluated the contribution of DOR and MaR to single‑lead and multi‑lead Tpe
Abstract This research focuses on the lives of three Icelandic women born early in the 20th century. The aim of this study was to try to understand how these women viewed their life and how they experienced the changes that Icelandic society has undergone in the 20th century. The women are viewed as active agents that shaped their own lives but also had to live within material and social constrai
Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with the incorporation of AI in endoscopy are being addressed in recent consensus documents. Objectives: In the current paper, we aimed to map future challenges and areas of research fo
Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t
