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MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive to transformation by MLL fusion proteins. To test this possibility, we used transgenic mice to induce

Aims: Research on the effect of unmet health-care needs on mortality at follow-up is scarce. This study investigated whether unmet health-care needs in 2008 were associated with a higher risk of mortality during a five-year follow-up period in a population in southern Sweden, and whether the association was stronger for particular subgroups of cause of death. Methods: The 2008 public-health survey

The objective of the present study was to assess the safety and effectiveness of vernakalant hydrochloride injection (RSD1235), a novel antiarrhythmic drug, for the conversion of atrial fibrillation (AF) or atrial flutter to sinus rhythm (SR) Patients with either AF or atrial flutter were randomized in a 11 ratio to receive vernakalant (n = 138) or placebo (n = 138) and were stratified by an arrhy

BACKGROUND: -Atrial fibrillatory rate (AFR) is a measure of atrial remodeling caused by atrial fibrillation (AF) and its acceleration negatively affects outcome of interventions for persistent AF. However, the prognostic value of AFR in patients with CHF has not been studied. We sought to evaluate whether AFR can predict outcome in patients with mild to moderate (NYHA II-III) congestive heart fail

The use of baseline lung function in the prediction of chronic obstructive pulmonary disease (COPD) hospitalisations, all-cause mortality and lung function decline was assessed in the population-based "Men Born in 1914" cohort.Spirometry was assessed at age 55 years in 689 subjects, of whom 392 had spirometry reassessed at age 68 years. The cohort was divided into three groups using fixed ratio (F

BACKGROUND: Improved surgical techniques and oncological treatment render many advanced pelvic tumors amenable to curative resection. We evaluated morbidity, survival, and quality of life (QoL) after extended pelvic procedures. METHODS: From January 2003 to November 2008, 85 patients underwent multivisceral pelvic resection; 87% had colorectal or anal malignancies. Preoperatively, endoscopy and im

The frame story
takes place in a dystopian Europe, possibly some kind of European Union around 2050 – in a state of conflicts and decay. The protagonists are a retired general, Piscator (cf. Fisher King) and a former journalist, Perle Vaus (cf. Perlesvaus/Perceval/Parsifal). She lost her home because of a new genderrelated law and stays homeless with others, covered by the Saxon bridge.

The objective of this paper is twofold. First, against the background of an existing empirical literature on the duration of trade which has found that international trade is often of strikingly short duration, we aim to establish whether or not EU imports from the rest of the world also are short-lived. Second, since there is at this point no clear commonly accepted theoretical explanation for th

Popular Abstract in Swedish Många av de äldre patienterna som är inlagda på sjukhus eller som bor i särskilda boenden inom äldreomsorgen är idag undernärda. En sammanställning av Socialstyrelsen över svenska studier under de senaste 20 åren visade på en genomsnittlig frekvens av undernäring på 28%. Ett otillräckligt kostintag leder till undernäring. Kroniska sjukdomar är ofta en bakomliggande orsThe aim of this thesis was to develop and test the feasibility of a dietary record routine, where nursing staff assess the patient’s food and fluid intake based on standardised portion sizes and household measurements. The energy intake (EI) was studied with a dietary record in 61 geriatric patients. During the 6-month follow-up 11 patients died and an EI below median (1378 kcal) was associated w

Aims: A study was undertaken to examine whether poor self-rated health (SRH) can independently predict all-cause mortality during 22-year follow-up in middle-aged men and women. Subjects and methods: Data are derived from a population-based study in Malmo¨ , Sweden. This included baseline laboratory testing and a self-administered questionnaire. The question on global SRH was answered by 15,590 me

To assess the association between height and risk of cancer and cancer death. The metabolic syndrome and cancer project is a prospective pooled cohort study of 585,928 participants from seven cohorts in Austria, Norway, and Sweden. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for cancer incidence and death were estimated in height categories and per 5-cm increment for each cancer site u

BackgroundPast research has identified aortic stenosis (AS) as a major risk factor for adverse outcomes in noncardiac surgery; however, more contemporary studies have questioned the grave prognosis. To further our understanding of this, the risks of a 30-day major adverse cardiovascular event (MACE) and all-cause mortality were investigated in a contemporary Danish cohort. HypothesisAS is not an i

The objective of this paper is to apply the Virtual Reference Feedback Tuning (VRFT) to Multiple-Input Multiple-Output (MIMO) control strategies in wastewater treatment plants (WWTPs). Using the Benchmark Simulation Model No. 1 (BSM1) as a case study, the proposed data-driven approach provides reduced-order controllers only using a batch of input-output data points (i.e. manipulated variable-contr

Background. This study aimed to determine whether the preoperative risk stratification model EuroSCORE predicts the different components of resource utilization in open heart surgery. Methods. Data for all adult patients undergoing heart surgery at the University Hospital of Lund, Sweden, between 1999 and 2002 were prospectively collected. Costs were calculated for the surgery and intensive care a

The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

We present the Pad Chamber detector system in the PHENIX experiment at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory. The three station system provides space points along each track in the spectrometer arms at mid-rapidity and covers a total area of 88 m(2). Its main functions are to provide the track coordinate along the beam and to ensure reliable pattern recogniti

Sexually transmitted diseases (STDs) have been shown to increase the Costs Of multiple mating and therefore favor relatively monogamous mating strategies. We examine another way in which STDs can influence mating systems in species in which female choice is important. Because more popular males are more likely to become infected, STDs can counteract any selective pressure that generates strong mat

Den här uppsatsen syftar till att undersöka huruvida det finns en rätt till abort inrymd i mänskliga rättigheter på en folkrättslig nivå. 47 000 kvinnor dör årligen på grund av osäkra aborter. Detta är något som enkelt kan förhindras genom en tillgång till säkra metoder erbjudna av sjukvård. Fem olika mänskliga rättigheter gås igenom under ett genusperspektiv. Dessa är: rätt till liv, rätt till h

In this study I examine current sexual music, made by women. I focus on songs made and/ or performed by contemporary female artists working in genres - such as hip-hop, pop and R&B - that fall under the umbrella term popular music. What kind of methods do these artists use to make a song feel or come across as sexual? Is it the lyrics? The sound? Could these songs come across as more or less s