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The M17 leucine aminopeptidase of the intraerythrocytic stages of the malaria parasite Plasmodium falciparum (PfLAP) plays a role in releasing amino acids from host hemoglobin that are used for parasite protein synthesis, growth, and development. This enzyme represents a target at which new antimalarials could be designed since metalloaminopeptidase inhibitors prevent the growth of the parasites i
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This master’s thesis focused on the crystallisation of E. coli ribonucleotide reductase repressor (NrdR) in the scope of fragment-based drug design. Antibiotic resistance is a growing problem and NrdR is thought to be a potential drug target for a new group of antibiotics. NrdR proteins are only found in bacteria and regulate the transcription of ribonucleotide reductase genes by binding to two Nr
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Climate warming is driving changes in species distribution, but habitat characteristics can interact with warming temperatures to affect populations in unexpected ways. We investigated wintering waterbird responses to climate warming depending on habitat characteristics, with a focus on the northern boundary of their non-breeding distributions where winter climatic conditions are more extreme. At