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Release properties of intrahippocampal transplants of noradrenergic neurons were monitored by microdialysis in awake and halothane-anaesthetized rats. Fetal locus coeruleus neurons were implanted as a cell suspension into hippocampi deprived of their innate noradrenalin (NA) innervation by intraventricular 6-hydroxydopamine treatment. Dialysis probes of the loop type were implanted into the dorsal

Parkinson's disease is associated with multiple cognitive impairments and increased risk of dementia, but the extent of these deficits varies widely among patients. The ICICLE-PD study was established to define the characteristics and prevalence of cognitive change soon after diagnosis, in a representative cohort of patients, using a multimodal approach. Specifically, we tested the 'Dual Syndrome'

Understanding past methane dynamics in arctic wetlands and lakes is crucial for estimating future methane release. Methane fluxes from lake ecosystems have increasingly been studied, yet only few reconstructions of past methane emissions from lakes are available. In this study, we develop an approach to assess changes in methane availability in lakes based on delta C-13 of chitinous invertebrate r

INTRODUCTION: Total alloplastic replacement of the temporomandibular joint (TMJ) is a viable treatment option for severe TMJ disorders (TMDs) unresponsive to conservative approaches, as well as for reconstruction of congenital or acquired TMJ defects. However, clinical data on indications, outcomes, complications and long-term effects remain limited, and no global registry currently exists. This s

Precise synchronization of paleoclimate records is essential for inferring the dynamics and past evolution of the climate system. For the last glacial period, the time scales of ice cores from the Greenland and Antarctic ice sheets have been synchronized by the use of cosmogenic radionuclides, atmospheric gas concentrations, and traces of large volcanic eruptions. Here we identify the sulfate depo

INTRODUCTIONBoreal forests are crucial for mitigating global climate change by capturing and storing large amounts of atmospheric carbon dioxide. However, previously unmanaged primary boreal forests are being rapidly transformed to managed secondary forests to meet the rising global demand for materials and energy. Understanding the effects of boreal primary to managed secondary forest transformat

Kan flexibilitet i hushålls energisystem underlätta energiomställningen genom att dra nytta av volatila elpriser? Analysen av vår fallstudie visar att flexibla teknologier och framför allt värmeproduktion från el kan minska fossila utsläpp och driftkostnader, men ökar elanvändningen från nätet. Priserna på el har diskuterats frekvent de senaste åren och kraftiga prissvängningar har negativt påveThe increasing share of weather-dependent renewable energy in the European electricity system, as a consequence of the European Union’s climate ambitions, has led to increased spot price volatility, negatively affecting consumers due to unpredictability. This case study assesses how flexibility (including power-heat cross vector flexibility) in residential buildings can affect annual costs, emissi

Background: Ambulatory oxygen therapy can be used to treat exertional hypoxaemia during daily life activities in people with fibrotic interstitial lung disease (ILD). However, evidence for its efficacy is scarce. This trial aimed to compare the effects of ambulatory oxygen with ambulatory air on physical activity in daily life over 6 months in people with fibrotic ILD and isolated exertional hypox

För att beviljas asyl måste queera asylsökande inför myndigheterna bevisa att de verkligen är queera. Om de inte gör det avslås deras ansökan som icke trovärdig och de riskerar att utvisas till sina ursprungsländer. I denna avhandling utforskar jag, genom möten med beslutsfattare, jurister, asylsökande och flyktingar, den affektiva produktionen av (o)trovärdig queerness inom det grekiska asylsysteTo be granted asylum, queer applicants must prove to the examining authorities that they are genuinely queer. Otherwise, their claims are rejected as non-credible, placing them at risk of deportation. In this thesis, I explore the affective production of (in)credible queerness in the Greek asylum apparatus. Through encounters with decision-makers, lawyers, asylum seekers, and refugees, I discuss t

Parasites play a fundamental role in explaining variation in population dynamics in wild ecosystems while also acting as a better model-system to study similar or related human infections. Since the late 1800s, malaria parasites have played a crucial role in vector-borne disease research. Many intrinsic and environmental factors can affect the level of infection transmission and prevalence among a

Popular Abstract in Swedish Finkorniga moräner betraktas ofta som problemjordar inom anläggningsbranschen beroende på jordarnas känslighet för förändringar i vatteninnehåll och för deras tjälegenskaper. I dagsläget används endast en begränsad mängd finkorniga moräner i anläggningsbyggande. Huvudmålet med denna avhandling har varit att öka kunskapen om dessa jordars egenskaper och att finna/utvecklFine-grained soils are often regarded as problematic soils in earthworks because of their water- and frost sensitivity. Only limited amounts of fine-grained tills are used as earthwork material today. The main objective of this thesis is to improve the knowledge of how to use and also treat a fine-grained till, so that a greater amount can be utilised as earthwork material. To achieve an increasin

Popular Abstract in English Antonie van Leeuwenhoek is known as the father of microbiology, because he made the first microscopic observation of bacteria in human history, published in 1683. For the naked human eyes, bacterial cells are too small to observe, and the development of microscopy techniques has since then been fundamental for examining bacterial cells. Recent advances in visualizing toCoiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. The best studied examples of the latter are crescentin in Caulobacter crescentus that determines the curved cell shape, and FilP (filament forming-p

Popular Abstract in Swedish Syftet med den här studien var att undersöka det strukturella underlaget för förslagen att makrofager och gaserna kvävemonooxid (NO) och kolmonoxid (CO), som bildas av kvävemonooxidsyntaser (NOS) respektive hemeoxygenaser (HO), är viktiga för att en perifer nerv ska regenerera. Det finns stöd för dessa hypoteser eftersom andra har visat att förhållanden som stör den invThe purpose of this study was to investigate the suggestions that macrophages, and the systems generating nitric oxide (NO) and carbon monoxide (CO), i.e. nitric oxide synthases (NOS) and heme oxygenases (HO), could be important for peripheral nerve regeneration. Immunocytochemistry was used to visualise invading and resident macrophages, inducible NOS (iNOS), two isoforms of HO (HO-1 and HO-2),

E-business is becoming more and more common today. The predictions of future growth give clear indications that companies will use e-business more and more. However in the growth of e-business it has been identified that there is a common lack of understanding in customer needs and logistics. In order to reduce some of this non-understanding this thesis seeks answers to the following question: - H

Popular Abstract in Swedish Populärvetenskaplig sammanfattning: När udda blir mainstream - om stress och likriktning i växtsamhället I skogen råder stress på många sätt, och precis som i det mänskliga samhället har stressen i växtsamhället ökat under de senaste decennierna. Dessa händelser har heller inte skett oberoende av varandra. Vårt allt snabbare tempo med krav på ökad tillväxt har inte baSoil acidification has become a source of serious concern in many parts of the world. In southern Sweden, the deposition of acidifying substances, such as nitrogen and sulphur compounds, has decreased the mean pH of forest soils by almost one unit since the 1950s. Apart from H+ ions themselves being harmful to plant roots, the potential toxicity of aluminium (Al) is increased when pH drops below 5

The interactions between uncharged polymers, e.g. ethyl(hydroxylethyl)cellulose (EHEC) and some model polymers, and ionic surfactants in aqueous solution has been studied by using isothermal titration and differential scanning calorimetry. We found that titration calorimetry could give quite detailed information about polymer - surfactant interactions. Values for the critical aggregation concentra

Popular Abstract in Swedish Ett beta-fosfoglukomutas i kolhydrat-metabolismen hos Lactococcus lactisPhosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two distinct forms of PGM have been purifed and charactierized in Lactococcus lactis growing on maltose: one specific for the alpha-isomer, and the other specific for the beta-isomer of glucose 1-phosphate. Beta-PGM was purified and polyclonal antisera to the enzyme were generated. Beta-PGM

Popular Abstract in Swedish Patienter med kroniskt obstruktiv lungsjukdom, KOL, har en försämrad lungfunktion och lider av bronkit och andnöd. Dessa symptom beror troligtvis på en ständigt pågående inflammation i lungan som dels leder till ökad slemproduktion och förträngning av luftrören, dels till emfysem dvs. nedbrytning av lungvävnaden vilket försämrar gasutbytet i lungan. Cigarrettrökning är Chronic obstructive pulmonary disease, COPD, is manifested by chronic airflow limitation due to inflammation and tissue destruction in the lungs. COPD is caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the future. The chronic inflammation in the lungs of these patients is thought to drive the pathogenesis fo