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The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. Comprehensive investigations of 15N backbone and 13C methyl side-chain confor
IMPORTANCE: The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.OBJECTIVE: To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.DESIGN, SETTING, AND PARTICIPANTS: Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicab
The Internet has revolutionised the global market place. Internet shopping is now accessible to an increasing numbers of people. In theory, this new form of media offers convenience, speed and choice to the consumer, but the question is whether it works in practice? Business-to-consumer cross-border transactions, whether carried out electronically or otherwise, are subject to the existing framewor
Popular science summary: Do bacteria survive in humans by eating the defense molecules during the course of infection? Enterococcus faecalis (E. faecalis) is a pathogen that can be found in the human gut which causes a wide range of infections including urinary tract infections, cardiovascular infections and bacteremia (presence of bacterial cells in blood stream). These bacteria can also be fou
Det här examensarbetet i geologi är en studie av ökensediment. Det är tvärvetenskapligt mellan geologi och ekologi. Sedimenten som har studerats kommer från en statlig försöksodling, El Hicha, på saltstäppen utanför El Akarit, 45 km norr om Gabes i södra Tunisien. Första steget i studien var att ta sediementprover på försöksodlingen där Ministry of Rural Engineering, Water and Forest odlar träd oc
Wind power developments in cold and icing conditions pose new challenges to the wind power industry. Icing of wind turbines cause safety hazards, production losses and increased loads. This means that there is a need to develop a technique to quantify the icing climatology and corresponding eects on wind turbines to enable large scale wind power developments in the windy, sparesly populated areas
Att behandla tumörsjukdomar genom injektion av radioaktiva läkemedel är en behandlingsteknik kallad radionuklidterapi. Det radioaktiva läkemedlet består av en radioaktiv isotop, fäst på en målsökande bärarmolekyl, specifik för den vävnad vari man önskar att läkemedlet skall ansamlas. Då den radioaktiva isotopen sönderfaller sänds joniserande strålning ut; strålning med förmågan att jonisera molekyIntroduction: There is a need of reassessment of radiation absorbed dose specification in nuclear medicine, taking the non-uniformities in the distribution of radioactivity into account. This is especially important in radionuclide therapies where very high activities are administered and the radionuclides emit alpha particles, beta particles or low-energy electron and will require absorbed dose c
Läckage och spill från cisterner utgör de vanligaste orsakerna till förorening av grundvatten med petroleumprodukter. Bensin och dieselföroreningar sprids inte enbart längs grundvattenytan utan lösta beståndsdelar kan transporteras med grundvattnet relativt långa sträckor. Flyktiga kolväten förflyttar sig i den vattenmättade zonen beroende på föroreningens utbredning och fördelning. Flera tusen aSpills and leaks from storage tanks constitute the most common groundwater contamination source with petroleum products. Gasoline and diesel pools do not spread extensively along the water table, but dissolved constituents are transported in groundwater on relatively larger distances. Volatile hydrocarbons migrate in the vadose zone dependently on distribution and extent of the dissolved and pure
Detta arbete har som syfte att besvara två frågeställningar - hur ser lagstiftningen ut för miljökonsekvensbeskrivningar för planer och program i Sverige, och vilka krav kan ställas utifrån denna, samt hur dessa krav har uppfattats i genomförda miljökonsekvensbeskrivningar för planer och program? Detta görs genom en genomgång av lagtext, förarbeten, praxis och litteratur på området, en granskning This work aims to answer two questions - how does the legislation for environmental impact assessments for plans and programs in Sweden look like, and what demands can be made from this, and how are these requirements perceived in conducted environmental impact assessments for plans and programs? This is done through a review of the statutory text, legislative history, case law and literature, an
Rollfördelningen mellan part och domstol har länge varit föremål för diskussioner i juridisk doktrin. Frågeställningar kring vilka omständigheter som föranleder domstol att tillgodose partsintressen genom materiell processledning eller övriga utredande åtgärder leder inte sällan till komplexa resonemang hänförliga till civilprocessens och förvaltningsprocessens egentliga funktion. Domstolens verksThe distribution of roles between the parties and the court has long been the subject of discussion in legal writing. Questions related to circumstances that cause the court to satisfy party interests through direction of proceedings or other investigative measures often leads to complex reasoning related the function of the different procedures, those of civil procedure and administrative judicia
Accessibility is something often taken for granted in our society, but it is a necessity for people with disabilities. Railway stations are a public place and are often a connecting point for several modes of transport. Design of railway stations in terms of accessibility for persons with disabilities is governed by several national and international governing documents. The purpose of this thesis
Background The 2002 EU directive on the energy performance of buildings stipulates that buildings must be energy certified. In order to implement the directive in Sweden it is proposed that a law on the energy certification of buildings be introduced on 1 January 2006. The law shall apply to all buildings where energy is used to condition the indoor climate. However, there are a number of exceptio
The current plastic system is unsustainable and needs to change. Plastics are mainly produced from fossil feedstock, contributing to greenhouse gas emissions, and low rate of post-consumer recycling results in pollution on land and in oceans with high ecological impact, and huge loss of valuable material. There is an urgent need to find solutions for shifting the raw material base to renewable res
The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac
Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessmen
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. Study I addresses the challenges associated with adapting CRISPR-Cas9 to the mitochondrial environment, and identifies
In Europe, willow (Salix spp.) trees have been used commercially since the 1980s at a large scale to produce renewable energy. While reducing fossil fuel needs, growing short rotation coppices (SRCs), such as poplar or willow, may have a high impact on local air quality as these species are known to produce high amounts of isoprene, which can lead to the production of tropospheric ozone (O3). Here
Importance: Preterm delivery has been associated with future cardiometabolic disorders in women. However, the long-term risks of chronic hypertension associated with preterm delivery and whether such risks are attributable to familial confounding are unclear. Such knowledge is needed to improve long-term risk assessment, clinical monitoring, and cardiovascular prevention strategies in women. Objec
