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Software product line engineering is an approach to cost-efficiently derive tailored products to markets and customers, utilizing common components and services in a planned manner. Product lines have been applied to other engineering fields for decades, while being quite recently introduced in software engineering. For software product lines, productivity gains are mostly related to the developme
The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro
Large market-driven software companies continuously receive large numbers of requirements and change requests from multiple sources. The task of analyzing those requests against each other and against already analyzed or implemented functionality then recording similarities between them, also called the requirements consolidation task, may be challenging and time consuming. This paper presents a r
Popular Abstract in Swedish Som en blixt från klar himmel drabbas en ung, och till synes frisk person, av hjärnblödning. Denna stroke leder till demens och efterföljande nya blödningar leder slutligen till en för tidig död. Man har kunnat visa att denna sjukdom beror på att en variant av ett visst protein, cystatin C, tvinnar ihop sig till rep-liknande långa fibriller. Dessa fibriller ansamlas sedAmyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein
Bakgrund: I bygg- och anläggningsbranschen skedde 1470 olyckor år 2018 där några även ledde till dödlig utgång (Arbetsmiljöverket, 2018). Utbildningen till maskinförare idag är både lång men grundlig och ger maskinföraren de förutsättningar som krävs för att framföra ett anläggningsfordon på ett säkert sätt på en byggarbetsplats. Genom regleringar från arbetsmiljöverket och förebyggande åtgärder aBackground: In the construction industry a total 1470 accidents occurred 2018 where some of them also led to fatal outcome (Arbetsmiljöverket, 2018). The qualification to be a construction machine operator are both long and thorough and will give the operator the prerequisites to convey the construction machine in a safe way on different construction sites. Through regulations from Arbetsmiljöverk
Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma.
Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe
In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.
selected photographs Hidden places tell us something about the diversity of city life, how places, and people, may have been forgotten or marginalised in the urbanisation process, or how places can be appropriated for diverse activities and uses outside of the sight and control of the authorities. These places may also reveal the other sides of busy tourist sites. But hidden places can also refer
https://www.ace.lu.se/hidden-places - 2026-07-19
The e-commerce market is growing explosively and the competition between retailers grows larger every day. Companies will have to step up their offers in order to keep customers, and one way to do this is to improve their packaging. The main goal of this master’s thesis is to develop a proposal for an e-commerce packaging with an improved customer experience for the online clothing retailer nelly.
Problem discussion: Industrial segmentation based on strategy requires a new course of action. How will overarching variables be chosen if the segmented objects change continuously? With which strategic sub variables will sub segments be created? Purpose: The theoretical purpose is to identify requirements on variables within segmentation of existing customers in industrial markets. Furthermore, i
Populärvetenskaplig sammanfattning: Kadmium är en tungmetall som liksom andra tungmetaller finns naturligt i miljön. Genom att människan finner användning för kadmium och använder sig av produkter som har kadmium som en förorening i sig kan större mängder ansamlas på ett ställe än vad som är naturligt. Kadmium kan man finna i bilar, båtar och andra maskiners metalldelar men också i avgaserna som sModelling of pollutants is commonly used in research and at departments working with environmental issues. The need to use large amounts of data when modelling creates the opportunity for more generalised models with lower data demands. Aggregating functions into coarser elements is a sort of generalisation of actual features in nature. A development of a method and a modelling tool called “Kadmiu
Hypoxia is getting worse in coastal areas of the Baltic Sea Oxygen in the World’s Oceans is Declining, Scientists Reveal Dangers and Solutions In the past 50 years, the amount of water in the open ocean without oxygen has gone up more than four-fold. In coastal water bodies, including estuaries and seas, low-oxygen sites have increased more than 10-fold since 1950. Protecting sensitive species, co
https://www.geology.lu.se/sites/geology.lu.se/files/ocean_deoxygenation_final-1.pdf - 2026-07-19
Purpose - To offer knowledge about the global development of largescale demand responsive transport systems (DRT), and to stimulate dialogue and collaboration for further innovation and improvement of these systems. Design/methodology/approach - A review of the literature shows how DRT has evolved from the first applications in the 1970s to very complex operations in the last two decades with hund
Denna uppsats undersöker korruptionsrisken som finns i offentlig upphandling med inriktning på mutbrott. Vilka är de riskfaktorer som bidrar till sårbarheter i offentlig upphandling som kan leda till korruption och uppsatsen förklarar hur upphandlingslagstiftningen är utformad för att motverka mutor hos myndigheter. Korruption är inget nytt fenomenen i den offentliga upphandlingen, utan det har aThis essay investigates the risk of corruption in public procurement with a focus on bribery. What are the risk factors that contribute to vulnerabilities in public procurement that could lead to corruption and the essay explains how the procurement legislation is designed to counteract bribery in public authorities. Corruption is not a new phenomenon in public procurement. There has always been
This paper examines the sufficiency of a trading method based on singular value decomposition (SVD) of past stock prices. The SVD method is frequently used as a tool to reduce data noise, compress big-data, and analyse data components. Hence, the method is well suited to form a ground for a predictive tool of price developments. From the predicted pattern, a strategy was formed by construction of
Syfte med uppsatsen är att jämföra kvantitativt förvaltade aktiefonder med traditionellt förvaltade aktiefonder under en 10-årsperiod, 2007–2017, samt under exceptionella chocker i form av upp- eller nedgång från 5 % i MSCI World Index. Jämförelsen gjordes med hjälp av riskjusterad avkastning i form av Sortino-kvot, Sharpe-kvot, informationskvot samt genom en regression. Endast en Sortino-maximeraThe purpose of this thesis is to compare quantitative management of stock-funds versus traditional management as a fundamental strategy, for a period of 10-years between 2007- 2017. Our essay has a special focus towards extreme market-conditions, which we defined as deviations of 5% in the MSCI World Index. Our analysis was made through the comparison of risk-adjusted measures as Sortino ratio, Sh
Begreppet flexibilitet har länge varit aktuellt på arbetsmarknaden. En aspekt av arbetsgivarens flexibilitet är möjligheten att ändra och anpassa arbetstidens förläggning och omfattning för att skapa en effektiv organisation. I samband med att arbetsgivaren vill genomföra en sådan organisationsförändring uppstår intressekonflikt mellan arbetsgivaren och arbetstagaren. Arbetsgivaren vill öka lönsam
