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Antibody-mediated blockade of CTLA4 has been shown to be effective in treating a select group of patients with late-stage melanoma. The precise mechanism underlying the clinical activity of CTLA4 immunotherapy is poorly understood, although recent experimental findings indicate that antibody-mediated depletion of regulatory T cells (Tregs) in the tumor microenvironment plays a key role in efficaci
Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. The
BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie
Popular Abstract in Swedish En tredjedel av befolkningen i världens industrialiserade länder lider av allergi, t.ex. allergisk rinit (hösnuva). Trots detta vet man relativt lite om de cellulära och molekylära mekanismer som ligger till grund för det immunologiska svaret vid allergi. Genom att studera dessa mekanismer kan man hitta sätt att angripa dem, vilket förhoppningsvis kan leda till bättre lAllergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t
Humanistlaboratoriet i artikel om möjliga framtida användningsområden för motion capture-teknik Humanistlaboratoriet i artikel om möjliga framtida användningsområden för motion capture-teknik Published 15 February 2022 Marianne Gullberg medverkar i en artikel om motion capture, VR och globala positionssystem, och diskuterar bland annat möjliga anvädningsområden i relation till försvar och säkerhet
Kära medlemmar i Nordic Network for Narratives in Medicine! Vi hoppas att 2023 börjat bra på alla sätt! Här kommer årets första nyhetsbrev och vi passar på att påminna läsarna om att skicka information till mig (Åsa) som ni tror att era med-medlemmar har intresse av. Har ni tankar kring ett möjligt tema för nästa nordiska nätverksmöte (i Trondheim), mejla gärna Katarina.Bernhardsson@litt.lu.se Art
The broad aim of this thesis is to explain the fundamental themes and function of Swedish field sermons and field prayers, and so to re-examine the view in earlier research that field sermons were primarily ‘Old Testamentary’ in nature. Inspired by more recent international research, I hold that the sermons’ basic functions were twofold: discipline and comfort. What matters, is to understand the d
The global coverage of sociology of law (SoL) has remained limited to the Western world, due to the difficult and problematic application of its current theories and concepts in non-Western societies. Thus, the sociology of law norm concept was studied in relation to the culture of Ashanti people of Ghana. This was done to identify and valorise culturally specific issues of their society that are
Genom Sveriges implementering av EU:s 2014 års upphandlingsdirektiv innehåller svensk rätt sedan år 2017 såväl fakultativa som obligatoriska bestämmelser om ställandet av arbetsrättsliga villkor i offentliga upphandlingar. Denna uppsats identifierar dock flera praktiska svårigheter gällande användandet av dessa bestämmelser på grund av den svenska arbetsmarknadsmodellens särdrag. I brist på en lagThrough Sweden's implementation of EU’s 2014 public procurement directives the Swedish legal system contains since 2017 optional and mandatory statutes regarding specific labour law requirements in public procurement. This thesis however identifies several practical difficulties regarding the use of these statutes because of the characteristics typical for the Swedish labour market model. The
The main purpose of this study is to examine whether a specific group of non ideal crime victims senses that the standard view of the ideal crime victim stands in the way of them getting the help from the judiciary that they are entitled to. If a discrepancy between theory and practice do exists, then why does it exist and what changes need to be done to eliminate it? These questions have been s
Den 9 december 1948 antogs konventionen om förebyggande och bestraffning av brottet folkmord. Begreppet “folkmord”, myntat av den framlidne professorn Raphael Lemkin, definieras som den systematiska förintelsen av gruppers grundläggande livsvillkor med syftet att förinta gruppen i sig. I artikel II av folkmordskonventionen definieras folkmord istället som handlingar som “förövas i avsikt att förin
Det straffrättsliga orsaksbegreppet har främst diskuterats i rättsvetenskaplig doktrin, eftersom det saknas en legaldefinition och mängden rättspraxis kring begreppet är begränsad i Sverige. År 2024 kom dock ett avgörande, NJA 2024 s. 36, där Högsta domstolen för första gången uttryckligen diskuterade orsaksbegreppet. Rättsfallet handlade om alternativ kausalitet i form av alternativa dödsorsakThe concept of causation in criminal law has been discussed mainly in legal doctrine, since there is no legal definition, and the amount of case law regard ing the concept is limited, in Sweden. In 2024, a decision was made, NJA 2024 s. 36, where the Swedish Supreme Court explicitly discussed the con cept of causation for the first time. The case was about alternative causality in the terms of
Aims/hypothesis High-energy breakfast and reduced-energy dinner (Bdiet) significantly reduces postprandial glycaemia in obese non-diabetic individuals. Our objective was to test whether this meal schedule reduces postprandial hyperglycaemia (PPHG) in patients with type 2 diabetes by enhancing incretin and insulin levels when compared with high-energy dinner and reduced-energy breakfast (Ddiet). Me
This PhD thesis deals with anthropomorphic images from the Vendel and Viking Ages, their contexts and functions. The images are seen as means of communication with “effective power” or agency ("Wirkmächtigkeit"). They could have had a relationship of interaction or partial identity with what was represented, due to the fact that the Vendel and Viking Age societies were largely based on oral tradit
The mass mobilization and the collective political engagement of the Gezi Park protests of 2013 came as a surprise for many in Turkey. What was new about these large-scale demonstrations was not only the sheer number of people taking place in them (more than 3.5 million), but rather the expansive range of the protesters.This presentation looks into the Gezi events through a research question of Ho
This study explores how scientists navigate research topic transitions during their early-career training and examines its impact on the production of novel knowledge. Drawing on survey data of 270 mid-career scientists in life sciences, we investigate their time investment in topics during early career stages (i.e. during PhD and postdoc training) and trace their research output for 15 years afteThis study explores how scientists navigate research topic transitions during their early-career training and examines its impact on the production of novel knowledge. Drawing on survey data of 270 mid-career scientists in life sciences, we investigate their time investment in topics during early career stages (i.e. during PhD and postdoc training) and trace their research output for 15 years afte
