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Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with
Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr
A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer of photoresist which is removed using oxygen ashing in a reactive ion etcher (RIE), with CHF3 plasma induced de
Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces
This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.
Studiens syfte var att undersöka effekterna på resurser och lönsamhet när en mellanhand standardiserar en fundamental resurs. Studien grundade sig i en kvalitativ flerfallsstudie av abduktiv ansats. Primärdatan erhölls genom semi-strukturerade intervjuer med restauranger i Lund. Dataanlysen genfördes sedan med hjälp av första- och andranivås kodning. Undersökningen utgick från den resursbaserade tThe purpose of the study was to investigate the impact on recourses and profitability when an intermediary standardizes a fundamental resource. The study is a qualitative multiple case study with an abductive approach. The primary data was collected using semi structured interviews with restaurants in Lund. The data was analysed by dividing it into first order categories and then into second order
Behovet av prisvärda bostäder är stort och byggsektorn måste i större utsträckning, än vad som i nuläget sker, möta de krav på billigare boende som ställs av marknaden. För att kunna bemöta denna efterfrågan måste en mer kostnadseffektiv byggprocess framträda. En lösning på detta är enligt byggkostnadsdelegationens betänkande ”Från byggsekt till byggsektor” en ökad industrialisering av byggandet.
I uppsatsen behandlas avdragsrätt för ingående mervärdesskatt på förvärv med koppling till aktieförsäljning, aktieförvärv och nyemission, utifrån svensk rätt och EG-rätt. Om ett bolag skall kunna medges avdragsrätt måste det vara skattskyldigt till mervärdesskatt. Enligt svensk rätt beror skattskyldigheten på om en person bedriver yrkesmässig verksamhet medan EG-rätten utgår från de transaktioner
Idag råder konsensus kring att människans aktivitet bidrar till klimat förändringar. Stater har ingått konventioner, utformat lagstiftning och tagit olika steg för att minska CO2 utsläpp. Statistiskt sett är utsläpp från flyg högre än utsläpp från sjöfart. Sjöfart är dock ett av de större transportsätt för att frakta gods över klotet, därför är det viktigt att utforma en reglering för CO2 utsläpp
The aim of this study was to examine the feelings experienced by family members of someone with a substance abuse. A qualitative approach has been used and the study was based on five autobiographical books, written by Swedish authors, both female and male. The focus was the authors’ described narrative, experiences and behaviors. The empirical material was analyzed using a gender perspective and
The traditional notuion of democracy being anchored in discussions among citizens is highlighted. The chapter makes the claim that while civic talk is central to the life of democracy, there are many socio-cultural factors that impede poitical discussion. Also, while formal deliberation is important, even the free-flowing, messy and unpredictable converations of everyday life can give rise to the
Signal transducer and activator of transcription 3 (STAT3) is known to be involved in the progression of prostate cancer (PCa) and is a key factor in drug resistance and tumor immunoescape. As a result, it represents a promising target for PCa therapy. We studied the effects of the STAT3 inhibitor galiellalactone (GL) on tumor growth and metastatic spread in vitro and in vivo. The effect of GL on
Popular Abstract in Swedish Komplementsystemet utgör en del av den medfödda immuniteten och är viktigt i försvaret mot angripande mikroorganismer. Ärftlig C2-brist (C2D) är en av de vanligaste bristerna inom komplementsystemet och förekommer i en frekvens av 1: 20 000 hos personer med västerländsk härstamning. I de aktuella undersökningarna har mer än 40 personer med C2D identifierats och observerThe complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. In the present investigation, the identification of more than 40 C2D persons at a single centre combined with long observation peri
In the current work, we compared the ability of 17 beta-estradiol (E-2) and the selective estrogen receptor modulators (SERMs), tamoxifen (Tam), raloxifene (Ral) and ospemifene (Osp) to promote the survival of osteoblast-derived cells against etoposide-incluced apoptosis. In order to compare the roles of the two estrogen receptor (ER) isotypes, we created a U2OS human osteosarcoma cell line stably
