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Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

https://www.psy.lu.se/en/sites/psy.lu.se.en/files/logon_to_a_zoom_meeting.pdf - 2026-07-09

https://www.geologi.lu.se/sites/geologi.lu.se/files/rutin_for_halso-_och_miljofarliga_kemikalier_v1.1.pdf - 2026-07-09

https://www.geologi.lu.se/sites/geologi.lu.se/files/rutin_for_halso-_och_miljofarliga_kemikalier_v1.1_ac.pdf - 2026-07-09

Within the field of cell biology, an essential tool is to deliver molecules to cells to manipulate cell behaviour and function. This enables the study of, for example, how a specific change in a cellular process contributes to a disease state. However, cells have barriers, such as the cell membrane, that need to be overcome for the molecules to have an effect. Current transfection methods, such as

Dosimetry Relativdosimetri Crister Ceberg Medical Radiation Physics Lund University Sweden Reference geometry Treatment unit Ion chamber => monitor units, UR Measurement point => absorbed dose, DR Water tank 𝐷𝑅 = 𝐷𝑅 𝑈𝑅 Treatment geometry • Distance from source, f • Collimator setting, c • Treatment depth in patient, z Relative dosimetry Reference geometry Treatment geometry fR f DDR z zR ccR

https://www.msf.lu.se/sites/msf.lu.se/files/4._relativdosimetri.pdf - 2026-07-09

Background: Breathlessness and exercise intolerance frequently impact the daily life of patients with COPD. Methods: This double-blind, multicentre, three-period crossover study randomised 111 patients with COPD (mean age 64 years, mean FEV1 38% of predicted normal) to budesonide/formoterol 320/9 mu g, formoterol 9 mu g or placebo, twice daily for 1 week, following a 1-week run-in period with 1-we

Introduction: Oncoplastic breast surgery (OBS) has been implemented with increasing frequency in the treatment of breast cancer. The aim of this study was to compare the oncologic outcome after OBS to the outcome after conventional breast-conserving surgery (BCS) in patients with invasive breast cancer. Patients and Methods: In all, 197 patients treated with OBS were compared to 1399 patients trea

A reliability-based approach to inspection planning for welded steel structures subjected to high cycle fatigue is presented in the current document. Inspections are an effective means to control the progress of fatigue deterioration and the presented approach allows to determine the minimum required inspection effort so that the considered structure complies with the given risk acceptance criteri