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Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality. Methods: Bloo
Current visual text analysis approaches rely on sophisticated processing pipelines. Each step of such a pipeline potentially amplifies any uncertainties from the previous step. To ensure the comprehensibility and interoperability of the results, it is of paramount importance to clearly communicate the uncertainty not only of the output but also within the pipeline. In this paper, we characterize t
Using examples from Poland, Elżbieta Drążkiewicz explores the question of why states become donors and individuals decide to share their wealth with others through foreign aid. She comes to the conclusion that the concept of foreign aid requires the establishment of a specific moral economy which links national ideologies and local cultures of charitable giving with broader ideas about the global
Denna avhandling studerar lokala aktörers roll vid förändringsarbete i gamla industriregioner. En gammal industriregion definieras som ett område med en ensidig och överspecialiserad industristruktur, som är dominerad av mogen industri och som upplever minskad sysselsättning och/eller avindustrialisering. Denna typ av region är ofta starkt påverkad av gamla strukturer och förväntas därför ha svåraThe aim of the dissertation is to develop a better understanding of the role of local agency in the transformation of old industrial regions. Theoretically the dissertation builds on concepts which are important in the debate on regional development in old industrial regions such as path dependency, negative lock-ins, the role of institutions, and new path development, while exploring and unpackin
Background: The CREST model is a prediction model, quantitating the risk of circulatory-etiology death (CED) after cardiac arrest based on variables available at hospital admission, and intend to guide the triage of comatose patients without ST-segment-elevation myocardial infarction after successful cardiopulmonary resuscitation. This study assessed performance of the CREST model in the Target Te
Concerns over the earth’s ability to sustain itself over the long term as a consequence of human consumption of natural resources points towards sustainable development. Since a large proportion of human consumption is linked to buildings and construction, this means managing the construction process in more sustainable ways. Strategies that target greater material efficiency and which promote cir
Monika Class reflects on some of the theoretical underpinnings of a translational, post-pandemic medical humanities and suggests that the concept of “material translation” might offer a productive way forward.
Background: This study investigated the association of two levels of targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) with administered doses of sedative and analgesic drugs, serum concentrations, and the effect on time to awakening. Methods: This substudy of the TTM2-trial was conducted at three centers in Sweden, with patients randomized to either hypothermia or
Kommunikatörsyrket inom offentlig sektor har på senare år varit på stark framväxt, men också i kraftig omvandling. Digitalisering, ökade förväntningar på organisationers kommunikation, en tilltagande medvetenhet i ledningen om kommunikationens strategiska betydelse, och alltmer komplexa verksamheter är några bakomliggande faktorer till den här utvecklingen. Det är också alltmer uppenbart att det s
Aim: Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM. Methods: Post-hoc analysis of time until awakening after cardiac arrest, its association with long-t
The populist turn in national and international politics includes one common question across countries: curbing immigration and limiting the rights of migrants. In the light of these restrictive tendencies, the questions that this article seeks to address are: whether and how the European Convention on Human Rights (ECHR), as interpreted by the European Court of Human Rights (ECtHR), can be a poin
Background: Current guidelines for the treatment of severe TBI recommend maintaining a cerebral perfusion pressure (CPP) at 60–70 mmHg. In our institution, as well as others, an alternative algorithm—originally named the Lund concept—has been used. This treatment algorithm employs metoprolol and clonidine to limit CPP, accepting levels below 60 mmHg, with the aim of reducing cerebral edema. Previo
In this article, I explore the assigned role of interpreters in journalism training programmes in Vietnam, focusing on two media aid projects funded by the Swedish International Development Cooperation Agency (Sida): the Local Radio Project and the Further Training of Journalists programme. The study is based on qualitative analyses of project documentation and interviews with former trainers. A t
Background: There are two conceptually different surgical treatment options for patients with T1 colorectal cancer (CRC): radical surgical resection and local resection. In addition, adjuvant chemotherapy is recommended in cases with lymph node metastases. However, surgical overtreatment of early CRC is a concern and may be related to limitations in preoperative work-up as well as tumour risk clas
Recent years have brought new directionality to university’s work with innovation – increasing the focus on addressing societal challenges and contributing to much broader frames for impact. Working with complex challenges, where no one actor can do everything by themselves, requires collaboration across actor groups (private sector, academia, public sector, civil society), industrial sectors, dis
Earlier treatment of breast cancer results in better survival. Screening enables this through detection of tumors before they cause symptoms. On the negative side, some tumors if not detected through screening would not cause symptoms, leading to overdiagnosis. Improvements in image quality allow even earlier detection and diagnosis of even smaller tumors at an even earlier stage. This study aims
Background: Palliative care needs in patients with cardiovascular diseases (CVD) are expected to increase. For the planning of equitable palliative care, it is important to understand where people with CVD die. The aim was to examine trends in place of death, associated factors including utilization of specialized palliative services, and to what extent longitudinal development is influenced by na
