Filtyp
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between cir
Nitrogen (N) is a key element in terrestrial ecosystems as it influences both plant growth and plant interactions with the atmosphere. Accounting for carbon–nitrogen interactions has been found to alter future projections of the terrestrial carbon (C) cycle substantially. Dynamic vegetation models (DVMs) aim to accurately represent both natural vegetation and managed land, not only from a carbon c
Visceral leishmaniasis (VL) is a potentially fatal vector-borne zoonotic disease, which has become an increasing public health problem in the north-western part of Iran. This work presents an environmental health modelling approach to map the potential of VL outbreaks in this part of the country. Radial basis functional link networks is used as a data-driven method for predictive mapping of VL in
Aims: In a co-twin control design, we aimed to examine whether individuals who initiate metformin treatment have an altered risk of incident diagnosis of osteoarthritis (OA), for up to 11 years after starting the treatment, compared with their non-treated co-twin. Methods: In all twin pairs different for metformin treatment (N=1 261 pairs) and all eligible twins/singletons (N=52 341) aged 35–75 ye
Feedbacks from the climate to other components of the coupled human-Earth system are expected to strongly influence the co-evolution of human society and its environment. Representing these feedback loops between climate and society, via the Earth system's response to human activities and the subsequent effect back onto social systems, is essential in order to fully explore the dynamics of the cou
Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i
Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee
Aluminum (Al), as a carbon-free energy source and energy carrier, features favorable characteristics regarding its production, transportation, utilization, and recyclability. However, the understanding of Al gas-phase combustion kinetics is still limited. The novelty of this work lies in presenting the first detailed and comprehensive analysis of the Al gas-phase mechanism in the air and steam env
Spark discharge generators (SDGs) are versatile tools for producing nanoparticles (NPs) with tailored properties. This study combines Computational Fluid Dynamics (CFD) and Particle Tracing (PT) simulations in COMSOL Multiphysics® with experimental data to investigate the effect of various chamber configurations, including inlet/outlet positioning and chamber volume on the NP output. Five geometri
BACKGROUND: It remains unclear why cool temperatures cause more persistent adverse health effects compared to hot weather. Fluid homeostasis may constitute a causal link between past temperatures and adverse health effects. In this study we investigated the association between past outdoor temperatures and current fluid homeostasis.METHODS: We studied participants from five cohorts during three de
Gate-tunable Josephson junctions with molybdenum superconducting contacts are reported. The Josephson field-effect transistors are based on an (In,Ga)As quantum well heterostructure with Mo contacts deposited on a layer of heavily doped (In,Ga)As by HCl cleaning and sputtering. We reproduced the measured data using a quasiballistic model that captures the gate dependence of the critical current an
We demonstrate the first fully vertical single-fin AlGaN FinFETs (Al = 2.5%) on ammonothermal n+-GaN substrates, featuring a gate length of Lg = 200 nm and excellent gate control. This work presents a systematic study of the impact of fin orientation along the a- and m-crystallographic planes on the electrical performance of AlGaN vertical FinFETs. We report that threshold voltage is maximized at
Objective: Meniscal calcifications are associated with meniscal degeneration and osteoarthritis (OA). We investigated micro-computed tomography (μCT) imaging for identification of calcification patterns caused by basic calcium phosphate (BCP) and calcium pyrophosphate (CPP). Design: Posterior horns of human medial and lateral menisci from 19 individuals with medial compartment knee OA and 21 decea
Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual
Background The mortality in individuals with a family history of heart failure (HF) has not been determined. This nationwide sib-pair study aimed to determine mortality in individuals with a sibling affected with HF. Methods Sib-pairs were linked using the Swedish Multi-Generation Register, the Hospital Discharge Register and the Cause of Death Register for the period 1987–2012. Families with card
Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering schemes, including use of gels and other materials derived from the scaffolds, the detailed composition and functional role of extracellular matrix (ECM) proteoglycans (PGs) and their glycosaminoglycan (GAG) chains remaining in decellularized lungs, is poorly understood. Using a commonly utilized detergent-base
Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approa
The boreal biome exchanges large amounts of carbon (C) and greenhouse gases (GHGs) with the atmosphere and thus significantly affects the global climate. A managed boreal landscape consists of various sinks and sources of carbon dioxide (CO2), methane (CH4), and dissolved organic and inorganic carbon (DOC and DIC) across forests, mires, lakes, and streams. Due to the spatial heterogeneity, large u
PURPOSE: The aim of this study was to investigate how the blood perfusion in human upper eyelid skin flaps is affected by the length of the flap and the degree of stretching and rotation of the flap.METHODS: Twenty-nine upper eyelids were dissected as part of a blepharoplastic procedure in patients. The 1-cm wide proximal end of the flap remains attached, to mimic a random pattern skin flap (herea
