Filtyp
Mantle plumes are subject of a great discussion within the field of Geology. Do they really exist, and in that case, from where do they originate? The scope of this Bachelor thesis is to discuss the characteristics of mantle plumes and the arguments in favor of and against their proposed existence. The mantle plume hypothesis was first presented in 1971 by Jason Morgan, suggesting diapirs of hot r
Biotechnological tools have never been stronger than today and the data they provide is absolutely fascinating. As we get a clearer picture of the intricate workings of living systems eective mathematical and statistical tools become a necessity in order to reach a comprehensive understanding of said systems. The purpose of this thesis is to statistically explore cutting edge biomedical data taken
En aktieägare har inget personligt betalningsansvar för aktiebolagets förpliktelser. Bolagets borgenärer har således endast bolagsförmögenheten som säkerhet för sina fordringar på bolaget. På grund av detta är det viktigt att en sådan förmögenhet tillförs bolaget då det bildas och att denna förmögenhet sedan stannar kvar i bolaget under verksamhetens gång, detta för att skydda borgenärerna. Det ärA shareholder has no personal liability for the obligations of the limited company. The creditors of the company have only the company assets as a collateral for their claims against the company. Therefor, it is important that capital is contributed to the company when it is founded and that the capital stays in the company during the activity, and this to protect the creditors. Owing to this, ref
Problem och syfte: Den här uppsatsen skall undersöka några av företeelserna som har betydelse för ett skapande av en europeisk identitet och ett "gemensamt" Europa. Diskussionen om Europa som gemensam institution handlar oftast om ekonomiska svårigheter, sällan diskuteras t.ex. historiska, normativa, och kulturella mellanmänskliga och mellanstatliga dilemman i större sammanhang. Frågan j
Bakgrunden till studien är min tidigare uppsats upplevelser av frihetsberövandet 2001. Uppsatsen hade som utgångspunkt att belysa hur oskyldigt frihetsberövade upplevde inlåsningen. Av resultatet framkom att samtliga upplevde häktningen i kombination med restriktioner som smärtsam, overklig och som tid av maktlöshet. I slutskedet av uppsatsen uppstod ett flertal frågeställningar exempelvis om roll
Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases
Objective To determine if familial diabetes burden across multiple kinship levels is associated with hospital-diagnosed COVID-19 in a population-based cohort. Methods We analyzed data from 15,516 participants in the Malmö Diet and Cancer Study (MDCS), a prospective, population-based cohort in southern Sweden. Familial burdens among first-degree relatives (parents, siblings, children) of diabetes,
Complement factor C3 is one of the most abundant proteins in the bloodstream and a central part of the complement system. Upon activation, C3 facilitates bacterial recognition and clearance in the extracellular environment. Initially regarded as a serum effector component, C3 is also emerging as an intracellular protein regulating basic cellular processes. Previously, we reported that intracellula
Background: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. Methods: We harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of car
Boreal forests play a crucial role in the global carbon cycle and currently act as an important carbon sink. At the same time, these forests are increasingly affected by intensive forest management and a changing disturbance regime driven by climate change. Clear-cutting has been the dominant harvesting method in managed boreal forests, while wildfire, although rare over the last century in Sweden
Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecB TA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs across bacteria, we surveyed the full RefSeq database. Phylogenetic and gene neighborhood analyses reveal three major SecB subfamilies: two housekeeping group
Obesity’s metabolic heterogeneity is not fully captured by body mass index (BMI). Here we show that deep multi-omics phenotyping of 1,408 individuals defines a metabolome-informed obesity metric (metBMI) that captures adipose tissue-related dysfunction across organ systems. In an external cohort (n = 466), metBMI explained 52% of BMI variance and more accurately reflected adiposity than other omic
Background: Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods: We conducted GWA
The International Society for Heart and Lung Transplantation Consensus for Perioperative Utilization of Extracorporeal Life Support in Lung Transplantation consists of 111 Delphi-derived statements across 3 separate manuscripts. These statements aim to provide comprehensive phase-of-care recommendations for international multidisciplinary teams to use in their clinical practice from time of recipi
The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l
Studies of the surface chemistry of the first few cycles of atomic layer deposition (ALD) using in situ and time-resolved operando techniques are attractive for realizing, understanding, and obtaining true mechanistic information during the deposition. However, the latter techniques are yet to be applied to ALD of metal nitrides. Here, we present a surface-chemistry investigation through a time-re
The direct integration of 1D magnetic nanostructures into electronic circuits is crucial for realizing their great potential as components in magnetic storage, logical devices, and spintronic applications. Here, we present a novel template-free technique for producing magnetic nanochains and nanowires using directed self-assembly of gas-phase-generated metallic nanoparticles. The 1D nanostructures
In2O3-based catalysts have shown high activity and selectivity for CO2 hydrogenation to methanol; however, the origin of the high performance of In2O3 is still unclear. To elucidate the initial steps of CO2 hydrogenation over In2O3, we have combined X-ray photoelectron spectroscopy and density functional theory calculations to study the adsorption of CO2 on the In2O3(111) crystalline surface with
